BMC Med:孕期有必要补充多种微量营养素吗?

2016-08-11 Seven L 译 MedSci原创

目的:孕妇补充多种微量营养素可以降低低出生体重儿风险,在中低收入国家一直推荐孕妇补充多种微量营养素以改善儿童生存、生长和健康。我们的目的是,对孕早期和中期开始补充多种微量营养素长期随访研究进行回顾。方法:干预包括≥3种微量营养素,对照组在可能的情况下服用铁(60 mg)和叶酸(400μG)。开始服用的中位数孕周从9-23周不等。主要结果是后代的死亡率、高、体重、头围。次要终点包括其他人体测量学指标

目的:孕妇补充多种微量营养素可以降低低出生体重儿风险,在中低收入国家一直推荐孕妇补充多种微量营养素以改善儿童生存、生长和健康。我们的目的是,对孕早期和中期开始补充多种微量营养素长期随访研究进行回顾。

方法:干预包括≥3种微量营养素,对照组在可能的情况下服用铁(60 mg)和叶酸(400μG)。开始服用的中位数孕周从9-23周不等。主要结果是后代的死亡率、高、体重、头围。次要终点包括其他人体测量学指标、身体成分、血压、肺功能及认知。

结果:纳入了9项试验的20个随访报道(包括88057名妇女),对后代的随访年龄从0-9岁不等。所有研究评估了后代死亡率;Meta分析结果显示病死率无差别(风险差异-0.05/1000活产儿;95 % CI, -5.25 to 5.15)。6项试验调查了人体测量学;发现随访过程中年龄相关体重z分(0.02; 95 % CI, -0.03 to 0.07)、年龄相关身高z分(0.01; 95 % CI, -0.04 to 0.06)或头围(0.11 cm; 95 % CI, -0.03 to 0.26)没有差异。身体成分、血压、肺功能方面没有差异;认知功能评分无一致性差异。

结论:目前还没有证据表明,与铁和叶酸补充剂相比,常规产前补充多种微量营养素可以改善儿童生存、成长、身体成分、血压、肺功能或认知结果。

原始出处:


Devakumar D.et al.Maternal antenatal multiple micronutrient supplementation for long-term health benefits in children: a systematic review and meta-analysis.BMC Med. 2016 Jun 16;14:90. doi: 10.1186/s12916-016-0633-3.


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    2016-09-05 山水寿0530

    不错,实用

    0

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level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Thu Aug 11 20:38:00 CST 2016, time=2016-08-11, status=1, ipAttribution=)]
  5. 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level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Thu Aug 11 20:38:00 CST 2016, time=2016-08-11, status=1, ipAttribution=)]
  6. 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level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Thu Aug 11 20:38:00 CST 2016, time=2016-08-11, status=1, ipAttribution=)]
    2016-08-12 忠诚向上

    好好学习

    0

  7. 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level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Thu Aug 11 20:38:00 CST 2016, time=2016-08-11, status=1, ipAttribution=)]
    2016-08-11 Guoxj3234

    学习起来

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2016042, encodeId=c105201604212, content=<a href='/topic/show?id=3479508222b' target=_blank style='color:#2F92EE;'>#微量营养素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50822, encryptionId=3479508222b, topicName=微量营养素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c64275, createdName=piaojinhua, createdTime=Thu Mar 30 06:36:00 CST 2017, time=2017-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1974688, encodeId=9cf819e4688a9, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, 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likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Fri Aug 12 06:10:00 CST 2016, time=2016-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97617, encodeId=0c649e6170f, content=学习起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151005/IMG5612955936CFA7964.jpg, createdBy=18621654109, createdName=Guoxj3234, createdTime=Thu Aug 11 21:59:00 CST 2016, time=2016-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97605, encodeId=01fd9e60570, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Thu Aug 11 20:38:00 CST 2016, time=2016-08-11, status=1, ipAttribution=)]
    2016-08-11 doctorJiangchao

    继续关注

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2016042, encodeId=c105201604212, content=<a href='/topic/show?id=3479508222b' target=_blank style='color:#2F92EE;'>#微量营养素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50822, encryptionId=3479508222b, topicName=微量营养素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c64275, createdName=piaojinhua, createdTime=Thu Mar 30 06:36:00 CST 2017, time=2017-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1974688, encodeId=9cf819e4688a9, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, 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likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Fri Aug 12 06:10:00 CST 2016, time=2016-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97617, encodeId=0c649e6170f, content=学习起来, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151005/IMG5612955936CFA7964.jpg, createdBy=18621654109, createdName=Guoxj3234, createdTime=Thu Aug 11 21:59:00 CST 2016, time=2016-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97605, encodeId=01fd9e60570, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Thu Aug 11 20:38:00 CST 2016, time=2016-08-11, status=1, ipAttribution=)]
    2016-08-11 doctorJiangchao

    继续学习

    0

  10. 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level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Thu Aug 11 20:38:00 CST 2016, time=2016-08-11, status=1, ipAttribution=)]
    2016-08-11 1dd8c52fm63(暂无匿称)

    了解了解!

    0

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PLoS One:补充微量营养素(MNS)可能会减缓病毒HIV转录

Fig 2. Density Strip Plot of Relative Risk of Progression to Clinical Disease/AIDS 约有2850万艾滋病毒携带者接受常规治疗(CD4 < 500),但目前并没有抗逆转录病毒药物用于治疗艾滋病。在相关HIV疾病治疗中降低血清中微量元素含量是很常见的一种治疗方法。补充微量营养素(MNS)可能会减轻疾病发展和降