Lancet:双手腕自发性骨折-案例报道

2016-05-06 Mechront 译 MedSci原创

患者男,72岁,因左手腕自发性骨折就诊。查体:患者的右手腕也有骨折。无淋巴结肿大。X片:骨折的尺骨远端广泛的溶骨性病变(如下图)。患者否认体重减轻、盗汗、前列腺问题等。PET:胸腹部未见原发性肿瘤,也没有发现其他骨骼病变,前列腺癌也不考虑。左尺骨活检:弥漫性大B细胞淋巴瘤。骨髓涂片和活检:未见恶性细胞。诊断:原发性骨质弥漫性大B细胞淋巴瘤 IIE期。治疗:3个周期的R-CHOP方案(利妥昔单抗治疗

患者男,72岁,因左手腕自发性骨折就诊。

查体:患者的右手腕也有骨折。无淋巴结肿大。

X片:骨折的尺骨远端广泛的溶骨性病变(如下图)。



患者否认体重减轻、盗汗、前列腺问题等。

PET:胸腹部未见原发性肿瘤,也没有发现其他骨骼病变,前列腺癌也不考虑。

左尺骨活检:弥漫性大B细胞淋巴瘤。

骨髓涂片和活检:未见恶性细胞。

诊断:原发性骨质弥漫性大B细胞淋巴瘤 IIE期。

治疗:3个周期的R-CHOP方案(利妥昔单抗治疗、环磷酰胺、阿霉素、长春新碱、强的松)和局部放疗。

弥漫性大B细胞淋巴瘤(DLBCL)是最常见的成人非霍奇金恶性淋巴瘤,以病人出现淋巴结内或结外迅速长大的肿块为典型表现,可伴有症状,且随着病情的发展发生扩散。原发淋巴结外的DLBCL发生率高达约40%,淋巴结外最常见部位是胃肠道(胃和回盲部),此外还可见于皮肤、中枢神经、骨、睾丸、软组织、腮腺、肺、女性生殖道、肝、肾、脾等任何部位。原发于骨髓或血液系统的情况罕见。本例患者则是原发于骨质的DLBCL。

原始出处:

Anna Roukens, Tom Vlasveld, et al.Vanishing ulnae: symmetrical diffuse large B-cell lymphoma.The Lancet.DOI: http://dx.doi.org/10.1016/S0140-6736(13)60144-0

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    2016-07-18 howi
  2. [GetPortalCommentsPageByObjectIdResponse(id=1828471, encodeId=6f3418284e173, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Mon Jul 18 04:18:00 CST 2016, time=2016-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129844, encodeId=e68312984417, content=点个赞!好文章有待学习探讨。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 18 06:30:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129473, encodeId=7f9b1294e3e4, content=不错哦,会学到很多,喜欢梅斯医学文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Sep 17 11:52:00 CST 2016, time=2016-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=108710, encodeId=d731108e102b, content=好文,值得学习,赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu Sep 01 08:48:00 CST 2016, time=2016-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106956, encodeId=90b210695681, content=深入学习,好文值得点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Aug 29 20:34:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84750, encodeId=e19384e50a6, content=学习了,很好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 15:14:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84751, encodeId=a3fd84e51c0, content=学习了,很好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 15:14:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530529, encodeId=6dbf153052980, content=<a href='/topic/show?id=ed4a860e872' target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584a12117168, createdName=sodoo, createdTime=Sun May 08 08:18:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84464, encodeId=97888446480, content=学习啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat May 07 09:36:00 CST 2016, time=2016-05-07, status=1, ipAttribution=)]
    2016-09-18 ylzr123

    点个赞!好文章有待学习探讨。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1828471, encodeId=6f3418284e173, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Mon Jul 18 04:18:00 CST 2016, time=2016-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129844, encodeId=e68312984417, content=点个赞!好文章有待学习探讨。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 18 06:30:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129473, encodeId=7f9b1294e3e4, content=不错哦,会学到很多,喜欢梅斯医学文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Sep 17 11:52:00 CST 2016, time=2016-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=108710, encodeId=d731108e102b, content=好文,值得学习,赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu Sep 01 08:48:00 CST 2016, time=2016-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106956, encodeId=90b210695681, content=深入学习,好文值得点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Aug 29 20:34:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84750, encodeId=e19384e50a6, content=学习了,很好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 15:14:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84751, encodeId=a3fd84e51c0, content=学习了,很好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 15:14:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530529, encodeId=6dbf153052980, content=<a href='/topic/show?id=ed4a860e872' target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584a12117168, createdName=sodoo, createdTime=Sun May 08 08:18:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84464, encodeId=97888446480, content=学习啦!, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat May 07 09:36:00 CST 2016, time=2016-05-07, status=1, ipAttribution=)]
    2016-09-17 1e10c84am36(暂无匿称)

    不错哦,会学到很多,喜欢梅斯医学文章

    0

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    2016-09-01 ylzr123

    好文,值得学习,赞!

    0

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    2016-08-29 ylzr123

    深入学习,好文值得点赞!

    0

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    2016-05-08 stead

    学习了,很好的

    0

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    2016-05-08 stead

    学习了,很好的

    0

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    2016-05-08 sodoo
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    2016-05-07 1dd8c52fm63(暂无匿称)

    学习啦!

    0

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