Diabetic Med:1型糖尿病患者早期肾功能下降的预测因素?

2017-10-27 MedSci MedSci原创

糖尿病肾病是1型糖尿病的主要并发症之一,但对其预测仍然很困难。近日,国际杂志 《Diabetic Medicine》上在线发表一项关1型糖尿病患者早期肾功能下降的预测因素的队列研究的结果。研究人员在两个1型糖尿病队列研究中调查了估计GFR(eGFR)快速下降的预测因子,两项研究就分别为1型糖尿病冠状动脉钙化(CACTI)和匹兹堡糖尿病并发症流行病学(EDC)。

糖尿病肾病是1型糖尿病的主要并发症之一,但对其预测仍然很困难。近日,国际杂志 《Diabetic Medicine》上在线发表一项关1型糖尿病患者早期肾功能下降的预测因素的队列研究的结果。研究人员在两个1型糖尿病队列研究中调查了估计GFR(eGFR)快速下降的预测因子,两项研究就分别为1型糖尿病冠状动脉钙化(CACTI)和匹兹堡糖尿病并发症流行病学(EDC)。 研究人员在17岁以下诊断为1型糖尿病且持续时间≥7岁的患者中选择的一组参与者(CACTI:n  = 210和EDC:n = 98),以随访8年CKD-EPI肌酐计算的eGFR数据进行分析。早期肾功能衰退被定义为每年eGFR下降≥3ml/min/ 1.73m2,和正常年龄相关的衰退eGFR≤1ml /min/1.73m2。在两个队列中构建并进行逻辑回归模型。 研究发现早期肾功能下降发生率CACTI为36%,EDC为41%。在两个队列中,较大的基线eGFR(CACTI:OR 3.12,95%CI 1.97-5.05; EDC:OR 1.92,95%CI 1.17-3.15 / 10ml / min / 1.73m 2)和对

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time=2017-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256484, encodeId=39f5256484e6, content=非常好的文章.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Fri Oct 27 23:10:12 CST 2017, time=2017-10-27, status=1, ipAttribution=)]
  5. 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time=2017-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256484, encodeId=39f5256484e6, content=非常好的文章.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Fri Oct 27 23:10:12 CST 2017, time=2017-10-27, status=1, ipAttribution=)]
    2017-11-15 yese
  6. 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time=2017-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256484, encodeId=39f5256484e6, content=非常好的文章.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Fri Oct 27 23:10:12 CST 2017, time=2017-10-27, status=1, ipAttribution=)]
  7. 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time=2017-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256484, encodeId=39f5256484e6, content=非常好的文章.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Fri Oct 27 23:10:12 CST 2017, time=2017-10-27, status=1, ipAttribution=)]
    2017-10-27 天涯183

    非常好的文章.谢谢

    0

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该研究的结果表明亚硝酸钠对EHT患者具有增强的降压效应。研究人员观察亚硝酸钠在两组受试者中均有抗利钠和抗利尿作用,并且仅在EHT受试者中可减少U-ENaC[γ]。在这两组中,研究人员发现了一个非血管加压素介导的U-AQP2减少,这是最有可能是代偿利尿作用的下降。