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Sci Transl Med：IgA对肠道细菌的影响

2018-05-07 药明康德 学术经纬

IgA肠道屏障肠道菌群
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免疫球蛋白A(immunoglobulin A， IgA)是最丰富的粘膜抗体。在动物模型中的实验表明它可能在加强肠道屏障，防止有害细菌伤害宿主方面有重要作用。

免疫球蛋白A(immunoglobulin A， IgA)是最丰富的粘膜抗体。在动物模型中的实验表明它可能在加强肠道屏障，防止有害细菌伤害宿主方面有重要作用。但是，IgA缺失的人类患者并不会出现严重感染，患者通常的症状是轻度呼吸道感染，遗传性过敏症(atopy)和自身免疫疾病。法国索邦大学(Sorbonne Université)的研究人员对健康人和IgA缺失患者的肠道菌群进行了研究。宏基因组学分析(metagenomic analysis)发现，IgA患者肠道中某些有害细菌群落出现扩增，但是有益共生菌群落的减少幅度低于预期值。IgM能够部分弥补IgA的功能，但是有些IgA靶点无法与IgM有效结合。他们的研究表明IgA在免疫/微生物界面起到控制致病菌群，调节系统炎症和维护菌群多样性等重要作用，但是它对维护肠道屏障没有显着作用。

原始出处：

Jehane Fadlallah，et al.Microbial ecology perturbation in human IgA deficiency.Sci Transl Med. 02 May 2018：Vol. 10， Issue 439， eaan1217

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createdName=yibei, createdTime=Wed May 09 04:17:00 CST 2018, time=2018-05-09, status=1, ipAttribution=)]
    2018-12-15 bsmagic9140

    #TRA#

    0

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    2018-09-25 ms3025846204744509

    #Transl#

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    2018-05-12 haige

    简明扼要.学习了!

    0

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GetPortalCommentsPageByObjectIdResponse(id=1369892, encodeId=ecec1369892a0, content=<a href='/topic/show?id=4f4081e22b0' target=_blank style='color:#2F92EE;'>#肠道细菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81722, encryptionId=4f4081e22b0, topicName=肠道细菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d17305, createdName=listen318, createdTime=Wed May 09 04:17:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503908, encodeId=859e1503908c7, content=<a href='/topic/show?id=641d94e7eb' target=_blank style='color:#2F92EE;'>#IgA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9477, encryptionId=641d94e7eb, topicName=IgA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c23f9697922, createdName=yibei, createdTime=Wed May 09 04:17:00 CST 2018, time=2018-05-09, status=1, ipAttribution=)]
    2018-05-11 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

  5. 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createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Tue Sep 25 12:17:00 CST 2018, time=2018-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314410, encodeId=89213144106e, content=简明扼要.学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdgSW0vVibEHQRlKXLlvMibvcHmy5ibwM7Luib2am6ywX6FqBrXibF8k7JVEzriaOSghltmYz1nomRd6TgSp2Yj9xHGAY/0, createdBy=9b2f2045808, createdName=haige, createdTime=Sat May 12 09:00:55 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313993, encodeId=21cc3139931c, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, 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createdName=yibei, createdTime=Wed May 09 04:17:00 CST 2018, time=2018-05-09, status=1, ipAttribution=)]
    2018-05-10 秀红

    学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1657003, encodeId=0010165e0039e, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Sat Dec 15 06:17:00 CST 2018, time=2018-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067346, encodeId=2476206e34667, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, 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createdName=yibei, createdTime=Wed May 09 04:17:00 CST 2018, time=2018-05-09, status=1, ipAttribution=)]
    2018-05-10 121832a9m88暂无昵称

    学习了

    0

  7. 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GetPortalCommentsPageByObjectIdResponse(id=1369892, encodeId=ecec1369892a0, content=<a href='/topic/show?id=4f4081e22b0' target=_blank style='color:#2F92EE;'>#肠道细菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81722, encryptionId=4f4081e22b0, topicName=肠道细菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d17305, createdName=listen318, createdTime=Wed May 09 04:17:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503908, encodeId=859e1503908c7, content=<a href='/topic/show?id=641d94e7eb' target=_blank style='color:#2F92EE;'>#IgA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9477, encryptionId=641d94e7eb, topicName=IgA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c23f9697922, createdName=yibei, createdTime=Wed May 09 04:17:00 CST 2018, time=2018-05-09, status=1, ipAttribution=)]
    2018-05-09 yfjms

    学习

    0

  8. 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createdName=yibei, createdTime=Wed May 09 04:17:00 CST 2018, time=2018-05-09, status=1, ipAttribution=)]
    2018-05-09 121832a9m88暂无昵称

    学习了

    0

  9. 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createdName=yibei, createdTime=Wed May 09 04:17:00 CST 2018, time=2018-05-09, status=1, ipAttribution=)]
    2018-05-09 listen318

    #肠道细菌#

    0

  10. 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createdName=yibei, createdTime=Wed May 09 04:17:00 CST 2018, time=2018-05-09, status=1, ipAttribution=)]
    2018-05-09 yibei

    #IgA#

    0

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