Gastroenterology: 炎症性肠病发病原因的环境危险因素分析

2019-09-22 不详 MedSci原创

多种环境因素与炎症性肠病(IBD)的发生发展都有关系。因此,本项荟萃分析进行了总体评估,以总结可用的流行病学证据并评估其可信度。

背景与目标
多种环境因素与炎症性肠病(IBD)的发生发展都有关系。因此,本项荟萃分析进行了总体评估,以总结可用的流行病学证据并评估其可信度。

方法
研究人员收集了所有包含观察性研究关于环境因素和IBD(克罗恩病[CD]或溃疡性结肠炎[UC])的风险。对于每个荟萃分析,研究人员均考虑了随机效应估计、95%置信区间、异质性估计和小研究效应,并根据预先确定的标准对证据进行了分级。方法质量由AMSTAR(即评估系统评价的测量工具)进行评估。

结果
研究人员对与生活方式,手术,药物接触,饮食,微生物和疫苗接种相关的71种环境因素进行了53项荟萃分析,对183种估计值进行了检查。确定了9种增加IBD风险的因素:吸烟(CD),城市生活(CD和IBD),阑尾切除术(CD),扁桃体切除术(CD),抗生素暴露(IBD),口服避孕药(IBD),软饮料消费(UC),维生素D缺乏症(IBD)和非幽门螺杆菌样肠肝菌(IBD)。同时确定了7种降低IBD风险的因素:体育锻炼(CD),母乳喂养(IBD),床铺共享(CD),茶饮(UC),高叶酸(IBD),高水平维生素D(CD),和幽门螺杆菌感染(CD,UC和IBD)。所有这些关联的流行病学证据都是高到中等强度的。

结论
在本项荟萃分析中研究人员发现了不同环境因素与IBD风险之间存在关联。

原始出处:

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    2019-11-22 许安
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    2020-08-17 智慧医人
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