Neurology:细颗粒物暴露与卒中发病率有啥关系?

2017-04-01 xing.T MedSci原创

由此可见,长期PM2.5暴露与发生缺血性卒中的风险较高相关,但与出血性脑卒中的相关性尚不太清楚。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在评估长期居住暴露于空气动力学直径小于2.5μm(PM2.5)的细颗粒物(PM)与卒中发病率和其主要亚型之间的相关性。

研究人员从于1998年-2001年招募的(基线)并随访至2010年12月31日的66820名中国香港老年人(65岁以上)队列中确定了急诊入院的首次发生脑卒中患者。每年的高分辨率(1×1km)的PM2.5平均浓度来自当地的监测数据和采用线性回归得到的美国国家航空航天局的卫星数据。基线住宅PM2.5暴露作为长期暴露的指标。研究人员使用Cox比例风险评估卒中发生风险与PM2.5暴露之间的相关性,在调整潜在的混杂因素后,包括个人和邻里因素。

平均随访了9.4年,研究人员共确定脑卒中患者6733例,其中缺血性脑卒中患者3526例(52.4%),出血性脑卒中患者1175例(17.5%)。在完全调整后的模型中,PM2.5浓度每增加10μg/m3的风险比在缺血性脑卒中患者中统计学上具有显著性为1.21(95%可信区间为1.04-1.41),而在出血性脑卒中患者中无统计学显著性为0.90(95%可信区间为0.70-1.71)。缺血性中风的估计在老年(70岁)、受教育程度较低和男性当前吸烟的参与者中更高。

由此可见,长期PM2.5暴露与发生缺血性卒中的风险较高相关,但与出血性脑卒中的相关性尚不太清楚。

原始出处:


Hong Qiu, et al. Fine particulate matter exposure and incidence of stroke. Neurology.2017.http://www.neurology.org/content/early/2017/03/31/WNL.0000000000003903.short

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    2017-11-26 yinhl1978
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objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/AiafG5m7kibldQyTnpaQicxg1rnBqFdIGgQBJJs4lR8ibmh91PibzgL7R7pl2HSBjgFeeKRV0mMCvDh49LrgJPCYYvA/132, createdBy=abc91707732, createdName=qjzhai1623, createdTime=Sun Apr 02 09:05:59 CST 2017, time=2017-04-02, status=1, ipAttribution=)]
    2018-01-11 lisa449
  5. 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objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/AiafG5m7kibldQyTnpaQicxg1rnBqFdIGgQBJJs4lR8ibmh91PibzgL7R7pl2HSBjgFeeKRV0mMCvDh49LrgJPCYYvA/132, createdBy=abc91707732, createdName=qjzhai1623, createdTime=Sun Apr 02 09:05:59 CST 2017, time=2017-04-02, status=1, ipAttribution=)]
    2017-04-05 tofsw

    学习了谢谢分享

    0

  6. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xjZ9qh3bhXrJtUlmycKGfQKPuADVZQsdNAQj5IrHHlzbGsDwScictBgogYRk8KhicpgEKwTEfOHgqw/0, createdBy=bc931611963, createdName=jin321, createdTime=Sun Apr 02 21:56:53 CST 2017, time=2017-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184521, encodeId=67f5184521c6, content=肉眼看不见的微粒堵在肉眼看不见的微循环里了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Sun Apr 02 09:28:27 CST 2017, time=2017-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184503, encodeId=a0b0184503d2, content=学习,但也没办法, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/AiafG5m7kibldQyTnpaQicxg1rnBqFdIGgQBJJs4lR8ibmh91PibzgL7R7pl2HSBjgFeeKRV0mMCvDh49LrgJPCYYvA/132, createdBy=abc91707732, createdName=qjzhai1623, createdTime=Sun Apr 02 09:05:59 CST 2017, time=2017-04-02, status=1, ipAttribution=)]
    2017-04-04 baihao215

    这样的研究数据大,统计学方法有讲究

    0

  7. 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objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/AiafG5m7kibldQyTnpaQicxg1rnBqFdIGgQBJJs4lR8ibmh91PibzgL7R7pl2HSBjgFeeKRV0mMCvDh49LrgJPCYYvA/132, createdBy=abc91707732, createdName=qjzhai1623, createdTime=Sun Apr 02 09:05:59 CST 2017, time=2017-04-02, status=1, ipAttribution=)]
    2017-04-03 1e10c84am36(暂无匿称)

    文章不错,值得分享

    0

  8. 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objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/AiafG5m7kibldQyTnpaQicxg1rnBqFdIGgQBJJs4lR8ibmh91PibzgL7R7pl2HSBjgFeeKRV0mMCvDh49LrgJPCYYvA/132, createdBy=abc91707732, createdName=qjzhai1623, createdTime=Sun Apr 02 09:05:59 CST 2017, time=2017-04-02, status=1, ipAttribution=)]
    2017-04-02 jin321

    每天吸雾霾如何

    0

  9. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xjZ9qh3bhXrJtUlmycKGfQKPuADVZQsdNAQj5IrHHlzbGsDwScictBgogYRk8KhicpgEKwTEfOHgqw/0, createdBy=bc931611963, createdName=jin321, createdTime=Sun Apr 02 21:56:53 CST 2017, time=2017-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184521, encodeId=67f5184521c6, content=肉眼看不见的微粒堵在肉眼看不见的微循环里了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Sun Apr 02 09:28:27 CST 2017, time=2017-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184503, encodeId=a0b0184503d2, content=学习,但也没办法, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/AiafG5m7kibldQyTnpaQicxg1rnBqFdIGgQBJJs4lR8ibmh91PibzgL7R7pl2HSBjgFeeKRV0mMCvDh49LrgJPCYYvA/132, createdBy=abc91707732, createdName=qjzhai1623, createdTime=Sun Apr 02 09:05:59 CST 2017, time=2017-04-02, status=1, ipAttribution=)]
    2017-04-02 lyh994

    肉眼看不见的微粒堵在肉眼看不见的微循环里了?

    0

  10. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xjZ9qh3bhXrJtUlmycKGfQKPuADVZQsdNAQj5IrHHlzbGsDwScictBgogYRk8KhicpgEKwTEfOHgqw/0, createdBy=bc931611963, createdName=jin321, createdTime=Sun Apr 02 21:56:53 CST 2017, time=2017-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184521, encodeId=67f5184521c6, content=肉眼看不见的微粒堵在肉眼看不见的微循环里了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Sun Apr 02 09:28:27 CST 2017, time=2017-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184503, encodeId=a0b0184503d2, content=学习,但也没办法, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/AiafG5m7kibldQyTnpaQicxg1rnBqFdIGgQBJJs4lR8ibmh91PibzgL7R7pl2HSBjgFeeKRV0mMCvDh49LrgJPCYYvA/132, createdBy=abc91707732, createdName=qjzhai1623, createdTime=Sun Apr 02 09:05:59 CST 2017, time=2017-04-02, status=1, ipAttribution=)]
    2017-04-02 qjzhai1623

    学习,但也没办法

    0

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研究结果表明,长期暴露于空气的PM2.5可能是导致高血压发生的重要危险因素,导致了中国成人高血压的负担很大。较高的水果消耗量可能会减轻,而超重和肥胖可以增强这种效应。

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Nature:研究揭示国际贸易相关PM2.5健康影响

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Stroke:PM2.5可怕,短期暴露更可怕!

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中国疾控中心研究表明,南方城市、老年人和男士受PM2.5影响更大

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