Neurology:睡眠呼吸紊乱增加民众卒中风险

2016-08-05 MedSci MedSci原创

美国约5000-7000万名成年人存在不同程度的睡眠障碍,这为他们增加某些健康风险。埃森大学医院的Dirk M.Hermann和同事指出,既往研究已经表明睡眠障碍与卒中的形成和预后有关。为了更好地了解这之间的关联,研究人员进行了一项荟萃分析研究,以评估睡眠障碍如失眠、阻塞性睡眠呼吸暂停(OSA)与卒中和预后之间的关系。2343名发生过缺血性卒中、出血性卒中或短暂性脑缺血发作(TIA)的患者参与研究

美国约5000-7000万名成年人存在不同程度的睡眠障碍这增加了他们的某些健康风险。

埃森大学医院的Dirk M.Hermann和同事指出既往研究已经表明睡眠障碍与卒中的形成和预后有关。为了更好地了解这之间的关联研究人员进行了一项荟萃分析研究以评估睡眠障碍如失眠、阻塞性睡眠呼吸暂停(OSA)与卒中和预后之间的关系。2343名发生过缺血性卒中、出血性卒中或短暂性脑缺血发作(TIA)的患者参与研究。

CDC指出,每年美国有13万人死于卒中。缺血性卒中最为常见占约87%。缺血性卒中是由于脑组织局部供血动脉血流的突然减少或停止,造成该血管供血区的脑组织缺血、缺氧,从而导致脑组织坏死、软化,并伴有相应部位的临床症状和体征。原发性出血性卒中系因脑血管壁病变、坏死、破裂导致的出血。短暂性脑缺血发作是局灶性脑缺血导致突发短暂性、可逆性神经功能障碍。发作持续数分钟,通常在30min内完全恢复,它被认为是卒中的警告信号,如果未经处理超过1/3的TIA患者将在一年内出现缺血性或出血性卒中。

Dirk M.Hermann博士和同事注意到睡眠障碍通常可以分为两种:睡眠呼吸紊乱(SDB)如阻塞性睡眠呼吸暂停综合征、反复呼吸停止和睡眠紊乱(SWD)如失眠、睡眠时间减少。 

研究人员发现72%的缺血性卒中患者、63%的出血性卒中患者、38%的TIA患者出现了SDB,这表明SDB可能增加民众出现卒中的风险。对于出血性和缺血性卒中的患者而言,SDB具有很大威胁,甚至影响患者的病后恢复进程。但是研究人员也提出采用持续气道正压(CPAP)等治疗手段可改善患者的睡眠状况,对卒中恢复有益。 

总体而言研究人员得出结论:SDB增加民众患卒中的风险,且如果不采取有效治疗手段改善患者呼吸,患者预后将不如所愿。此外,研究人员也发现相关证据支持结论:失眠、不宁腿综合症、嗜睡等也增加民众出现卒中的风险并影响患者恢复进程,但是这些都不如SDB明显。

Hermann博士指出,睡眠是改善大脑功能的重要手段,使神经元功能恢复,从而改善卒中患者预后。因此他建议有卒中风险的民众应关注睡眠问题。

原始出处:

[1] Sleep disorders increase stroke risk harm recovery. MNT.2016 August 4.

[2] Dirk M. Hermann et al. Role of sleep-disordered breathing and sleep-wake disturbances for stroke and stroke recovery. Neurology.2016 August 3. 

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    2018-08-02 汪海波

    Osahs导致慢性缺氧,凝血功能异常,最终导致卒中!所以,什么时候才是启动抗凝?或者是否需要常规抗凝?

    0

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    2017-03-10 yinhl1978
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    2016-10-09 ylzr123

    学习了,文章有深度,值得探究。

    0

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    2016-09-18 1e10c84am36(暂无匿称)

    不错哦继续关注

    0

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    2016-09-03 李东泽

    很好,不错,以后会多学习

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=335826, encodeId=01353358263a, content=Osahs导致慢性缺氧,凝血功能异常,最终导致卒中!所以,什么时候才是启动抗凝?或者是否需要常规抗凝?, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c53c2405614, createdName=汪海波, createdTime=Thu Aug 02 19:04:31 CST 2018, time=2018-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999738, encodeId=caab1999e3894, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Fri Mar 10 07:03:00 CST 2017, time=2017-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1989015, encodeId=d27419890151a, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Wed Jun 28 15:03:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=142616, encodeId=bcff142616a0, content=学习了,文章有深度,值得探究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Oct 09 13:29:14 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=130199, encodeId=3bb013019915, content=不错哦继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 18 15:21:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=110116, encodeId=7b5b11011652, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Sep 03 07:57:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1281223, encodeId=b59f12812231b, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36085, encryptionId=455f36085f0, topicName=卒中风险)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sun Aug 07 12:03:00 CST 2016, time=2016-08-07, status=1, ipAttribution=)]

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