BRIT J PSYCHIAT:累积使用电休克治疗(ECT)会导致抑郁症患者认知损害?

2015-11-23 徐媛 MedSci原创

电休克治疗(ECT)在治疗严重性抑郁症最有效的手段,但患者及医生普遍认为长期使用ECT会导致认知功能损伤。本研究目的是重复或持续使用ECT是否会导致累积的认知损害。 研究人员收集并分析了199名患者10年间认知功能的数据。对199名患者进行了498次的评估,平均15.3次对话(范围0 - 186)。使用线性混合效应回归模型进行了分析。结果表明先前ECT治疗总次数对认知功能无显著效应,真正影响

电休克治疗(ECT)在治疗严重性抑郁症最有效的手段,但患者及医生普遍认为长期使用ECT会导致认知功能损伤。本研究目的是重复或持续使用ECT是否会导致累积的认知损害。

研究人员收集并分析了199名患者10年间认知功能的数据。对199名患者进行了498次的评估,平均15.3次对话(范围0 - 186)。使用线性混合效应回归模型进行了分析。结果表明先前ECT治疗总次数对认知功能无显著效应,真正影响患者认知功能的主要因素为年龄,其次为认知评估时的抑郁严重度,以及距离上次ECT治疗的时间。

以上研究结果表明重复使用ECT并不能导致累积的认知损害。这对于患者或医生无疑是一个好消息。

原始出处

George G. Kirov, Laura Owen, Hazel Ballard, Adele Leighton, Kara Hannigan, Danielle Llewellyn, Valentina Escott-Price, Maria Atkins.Evaluation of cumulative cognitive deficits from electroconvulsive therapy. The British Journal of Psychiatry Nov 2015,

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