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Mater Sci Eng C Mater Biol Appl：骨再生支架材料的又一选择

2018-01-23 MedSci MedSci原创

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具有类似人骨的机械和生物特性的复合材料对于骨再生和修复来说是必需的。在本研究中，研究人员通过将生物活性玻璃（BG）掺入聚己内酯（PCL）-聚乙烯醇（PVA）（PCLPVA）基质中制备复合材料。采用原位共混法制备了BG含量分别为10、25和50wt%的复合材料。理化性质测定发现，PCLPVA有机基质中含50wt%BG的复合材料的力学性能（抗压强度和压缩杨氏模量分别高达32.26MPa和530.91M

具有类似人骨的机械和生物特性的复合材料对于骨再生和修复来说是必需的。在本研究中，研究人员通过将生物活性玻璃（BG）掺入聚己内酯（PCL）-聚乙烯醇（PVA）（PCLPVA）基质中制备复合材料。

采用原位共混法制备了BG含量分别为10、25和50wt%的复合材料。理化性质测定发现，PCLPVA有机基质中含50wt%BG的复合材料的力学性能（抗压强度和压缩杨氏模量分别高达32.26MPa和530.91MPa）最好。使用体外细胞培养测定法研究了BG含量对在支架上生长的UMR-106细胞的细胞粘附、增殖和成骨活性的影响。结果显示25wt%BG的复合支架细胞粘附和增殖能力最强。在仅仅5天的培养后出现细胞粘附和伸展形态。

由于这些原因，我们选择将骨形成蛋白（BMP）-2附着到该复合物上，制备负载BMP-2的PCLPVABG25，结果显示可显著改善UMR-106细胞的粘附功能，增强了该复合物的成骨分化和骨诱导性。

原始出处：

Keothongkham K, Charoenphandhu N, et al., Evaluation of bioactive glass incorporated poly(caprolactone)-poly(vinyl alcohol) matrix and the effect of BMP-2 modification. Mater Sci Eng C Mater Biol Appl. 2017 May 1;74:47-54. doi: 10.1016/j.msec.2016.12.128. Epub 2017 Jan 7.

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    2018-04-03 12498ebem31暂无昵称

    #Biol#

    0

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    2018-09-27 zhouqu_8

    #Eng#

    0

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    2018-05-27 sunylz

    #Bio#

    0

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    2018-04-18 tidiq

    #支架材料#

    0

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    2018-01-25 lsj630

    #骨再生#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1767366, encodeId=103b1e673669b, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Tue Apr 03 03:10:00 CST 2018, time=2018-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081438, encodeId=a27e2081438dd, content=<a href='/topic/show?id=57406e8506' target=_blank style='color:#2F92EE;'>#Eng#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6785, encryptionId=57406e8506, topicName=Eng)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Thu Sep 27 22:10:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917893, encodeId=3e36191e89340, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun May 27 08:10:00 CST 2018, time=2018-05-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775800, encodeId=e42e1e758000a, content=<a href='/topic/show?id=a7235e107b2' target=_blank style='color:#2F92EE;'>#支架材料#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57107, encryptionId=a7235e107b2, topicName=支架材料)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce4f38811844, createdName=tidiq, createdTime=Wed Apr 18 22:10:00 CST 2018, time=2018-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472102, encodeId=ed6614e210231, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Thu Jan 25 08:10:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281346, encodeId=c10928134699, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b10c1938054, createdName=1e0e5697m83(暂无匿称), createdTime=Tue Jan 23 21:34:11 CST 2018, time=2018-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281319, encodeId=b227281319f7, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Tue Jan 23 19:45:52 CST 2018, time=2018-01-23, status=1, ipAttribution=)]
    2018-01-23 1e0e5697m83(暂无匿称)

    henhao

    0

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    2018-01-23 131****1460

    学习了受益匪浅

    0