PLoS One:糖尿病可增加小动脉闭塞型卒中的复发和不良预后风险

2016-06-30 phylis 译 MedSci原创

背景:糖尿病(DM)与轻型卒中预后的关系尚不清楚。本研究的目的是调查糖尿病是否与轻型卒中或特定亚型的预后相关。方法:所有轻型缺血性脑卒中患者均来自中国国家卒中登记处,根据TOAS T标准将其分为5种亚型。糖尿病定义为自称医生诊断为糖尿病或在住院或出院时使用降糖药物。随访1年,观察复发性脑卒中、死亡和功能转归。功能预后不良为改良Rankin评分2-6。应用单因素和多因素Logistic回归分析DM和

背景:糖尿病(DM)与轻型卒中预后的关系尚不清楚。本研究的目的是调查糖尿病是否与轻型卒中或特定亚型的预后相关。

方法:所有轻型缺血性脑卒中患者均来自中国国家卒中登记处,根据TOAS T标准将其分为5种亚型。糖尿病定义为自称医生诊断为糖尿病或在住院或出院时使用降糖药物。随访1年,观察复发性脑卒中、死亡和功能转归。功能预后不良为改良Rankin评分2-6。应用单因素和多因素Logistic回归分析DM和轻型脑卒中及其亚型的预后之间的相关性。

结果:4548例轻型脑卒中患者中,1230例(27%)患者有糖尿病,1038(22.8%)患者预后不良, 570例/4401(13%)患者在1年时复发性脑卒中。多变量分析中,糖尿病与1年
卒中复发(OR,1.31;95% CI:1.08-1.59)和预后不良(OR,1.51;95% CI:1.28-1.77)显著相关。轻度卒中亚型中,DM仅与小动脉闭塞型卒中1年卒中复发相关(OR,1.63;95% CI:1.07-2.50)和预后不良(OR,1.73;95% CI:1.22-2.45)相关。

结论:糖尿病明显增加小动脉闭塞亚型卒中复发和不良预后的风险,但与轻型卒中的其他类型无关。

原始出处

Pan Y, Wang Y, et al. Association of Diabetes and Prognosis of Minor Stroke and Its Subtypes: A Prospective Observational Study. PLoS One. 2016 Apr 12


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    2016-10-11 ylzr123

    拜读了,受益匪浅,点个赞!

    0

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    2016-07-04 保守主义

    感觉应该是的

    0

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血液中甘油三酯水平高会增加心脏病风险,还有可能增加2型糖尿病风险。一项发表在国际学术期刊Diabetes Care上的研究首次证明大幅降低糖尿病病人的甘油三酯能够改善他们的胰岛素敏感性,有助于帮助病人控制血糖水平。另外,一种试验性降脂药物Volanesorsen能够显著降低病人整体的糖化血红蛋白并改善胰岛素敏感性和血糖控制。该研究由美国宾夕法尼亚大学Perelman医学院的研究人员完成。&nbs