进展

订阅

MedSci主页 / 所有栏目 / 进展

Aliment Pharmacol Ther：埃索美拉唑可预防非甾体抗炎药服用者溃疡复发

2012-08-16 不详 网络

埃索索美美拉拉唑唑可可预预防防非非甾甾体体抗抗炎炎药药服服用用者者溃溃疡疡复
关注

众所周知，质子泵抑制剂可用于预防非甾体抗炎药(NSAID)引起的胃肠道不良事件。然而在日本，关于这种治疗方法的疗效和安全性的数据还很少。为了评估日本高危患者应用埃索美拉唑预防NSAID引起的消化性溃疡的的疗效和耐受性。研究者招募了胃镜证实有溃疡病史，并且需要长期口服NSAID治疗慢性炎症的日本成年(≥20岁)患者，将其随机分组，给予埃索美拉唑20 mg/d或安慰剂，共24周。主要终点是Kaplan

众所周知，质子泵抑制剂可用于预防非甾体抗炎药(NSAID)引起的胃肠道不良事件。然而在日本，关于这种治疗方法的疗效和安全性的数据还很少。为了评估日本高危患者应用埃索美拉唑预防NSAID引起的消化性溃疡的的疗效和耐受性。研究者招募了胃镜证实有溃疡病史，并且需要长期口服NSAID治疗慢性炎症的日本成年(≥20岁)患者，将其随机分组，给予埃索美拉唑20 mg/d或安慰剂，共24周。主要终点是Kaplan-Meier估计的无溃疡率。

结果显示，共有343名患者接受随机治疗(埃索美拉唑组175例；安慰剂组168例)。在24周治疗期间，埃索美拉唑组(96.0％；95％CI，92.8~99.1)Kaplan-Meier估计的无溃疡率明显高于安慰剂组(64.4％；95％CI，56.8~71.9)(数秩P＜0.001)。埃索美拉唑对幽门螺杆菌阳性和阴性患者的消化性溃疡均能有效地预防，而安慰剂组幽门螺旋杆菌阳性患者无溃疡率显著低于阴性患者(59.7％ vs. 69.9％)。NSAID的类型似乎并不影响估算的无溃疡率。埃索美拉唑治疗耐受性良好。

研究者总结认为，埃索美拉唑20 mg/d可安全有效地预防有明确溃疡病史且服用NSAID患者的溃疡复发。

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1908149, encodeId=1bdf190814944, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Fri Apr 26 08:30:00 CST 2013, time=2013-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787123, encodeId=9bd11e8712395, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Sun Jan 27 13:30:00 CST 2013, time=2013-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995876, encodeId=5c2e19958e6d7, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Wed Oct 17 09:30:00 CST 2012, time=2012-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788140, encodeId=fa491e8814098, content=<a href='/topic/show?id=38e014162e2' target=_blank style='color:#2F92EE;'>#Pharmacol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14162, encryptionId=38e014162e2, topicName=Pharmacol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Sat Dec 22 21:30:00 CST 2012, time=2012-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338684, encodeId=df8b13386846e, content=<a href='/topic/show?id=afff99560c4' target=_blank style='color:#2F92EE;'>#非甾体抗炎药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99560, encryptionId=afff99560c4, topicName=非甾体抗炎药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/7F67E3BE360D6DD1D0A62E3E71E23CB6/100, createdBy=9d8a2500148, createdName=ms8888626721583891, createdTime=Sat Aug 18 07:30:00 CST 2012, time=2012-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1346705, encodeId=aa151346e05e3, content=<a href='/topic/show?id=f20155404fc' target=_blank style='color:#2F92EE;'>#抗炎药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55404, encryptionId=f20155404fc, topicName=抗炎药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sat Aug 18 07:30:00 CST 2012, time=2012-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591745, encodeId=80201591e4568, content=<a href='/topic/show?id=90cb415e5f2' target=_blank style='color:#2F92EE;'>#埃索美拉唑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41575, encryptionId=90cb415e5f2, topicName=埃索美拉唑)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=zhangpaul93, createdTime=Sat Aug 18 07:30:00 CST 2012, time=2012-08-18, status=1, ipAttribution=)]
    2013-04-26 chentianping

    #pharma#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1908149, encodeId=1bdf190814944, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Fri Apr 26 08:30:00 CST 2013, time=2013-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787123, encodeId=9bd11e8712395, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Sun Jan 27 13:30:00 CST 2013, time=2013-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995876, encodeId=5c2e19958e6d7, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Wed Oct 17 09:30:00 CST 2012, time=2012-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788140, encodeId=fa491e8814098, content=<a href='/topic/show?id=38e014162e2' target=_blank style='color:#2F92EE;'>#Pharmacol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14162, encryptionId=38e014162e2, topicName=Pharmacol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Sat Dec 22 21:30:00 CST 2012, time=2012-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338684, encodeId=df8b13386846e, content=<a href='/topic/show?id=afff99560c4' target=_blank style='color:#2F92EE;'>#非甾体抗炎药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99560, encryptionId=afff99560c4, topicName=非甾体抗炎药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/7F67E3BE360D6DD1D0A62E3E71E23CB6/100, createdBy=9d8a2500148, createdName=ms8888626721583891, createdTime=Sat Aug 18 07:30:00 CST 2012, time=2012-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1346705, encodeId=aa151346e05e3, content=<a href='/topic/show?id=f20155404fc' target=_blank style='color:#2F92EE;'>#抗炎药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55404, encryptionId=f20155404fc, topicName=抗炎药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sat Aug 18 07:30:00 CST 2012, time=2012-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591745, encodeId=80201591e4568, content=<a href='/topic/show?id=90cb415e5f2' target=_blank style='color:#2F92EE;'>#埃索美拉唑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41575, encryptionId=90cb415e5f2, topicName=埃索美拉唑)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=zhangpaul93, createdTime=Sat Aug 18 07:30:00 CST 2012, time=2012-08-18, status=1, ipAttribution=)]
    2013-01-27 jj000001

    #Pharm#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1908149, encodeId=1bdf190814944, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Fri Apr 26 08:30:00 CST 2013, time=2013-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787123, encodeId=9bd11e8712395, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Sun Jan 27 13:30:00 CST 2013, time=2013-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995876, encodeId=5c2e19958e6d7, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Wed Oct 17 09:30:00 CST 2012, time=2012-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788140, encodeId=fa491e8814098, content=<a href='/topic/show?id=38e014162e2' target=_blank style='color:#2F92EE;'>#Pharmacol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14162, encryptionId=38e014162e2, topicName=Pharmacol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Sat Dec 22 21:30:00 CST 2012, time=2012-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338684, encodeId=df8b13386846e, content=<a href='/topic/show?id=afff99560c4' target=_blank style='color:#2F92EE;'>#非甾体抗炎药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99560, encryptionId=afff99560c4, topicName=非甾体抗炎药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/7F67E3BE360D6DD1D0A62E3E71E23CB6/100, createdBy=9d8a2500148, createdName=ms8888626721583891, createdTime=Sat Aug 18 07:30:00 CST 2012, time=2012-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1346705, encodeId=aa151346e05e3, content=<a href='/topic/show?id=f20155404fc' target=_blank style='color:#2F92EE;'>#抗炎药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55404, encryptionId=f20155404fc, topicName=抗炎药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sat Aug 18 07:30:00 CST 2012, time=2012-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591745, encodeId=80201591e4568, content=<a href='/topic/show?id=90cb415e5f2' target=_blank style='color:#2F92EE;'>#埃索美拉唑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41575, encryptionId=90cb415e5f2, topicName=埃索美拉唑)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=zhangpaul93, createdTime=Sat Aug 18 07:30:00 CST 2012, time=2012-08-18, status=1, ipAttribution=)]
    2012-10-17 yb6560

    #MAC#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1908149, encodeId=1bdf190814944, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Fri Apr 26 08:30:00 CST 2013, time=2013-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787123, encodeId=9bd11e8712395, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Sun Jan 27 13:30:00 CST 2013, time=2013-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995876, encodeId=5c2e19958e6d7, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Wed Oct 17 09:30:00 CST 2012, time=2012-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788140, encodeId=fa491e8814098, content=<a href='/topic/show?id=38e014162e2' target=_blank style='color:#2F92EE;'>#Pharmacol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14162, encryptionId=38e014162e2, topicName=Pharmacol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Sat Dec 22 21:30:00 CST 2012, time=2012-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338684, encodeId=df8b13386846e, content=<a href='/topic/show?id=afff99560c4' target=_blank style='color:#2F92EE;'>#非甾体抗炎药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99560, encryptionId=afff99560c4, topicName=非甾体抗炎药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/7F67E3BE360D6DD1D0A62E3E71E23CB6/100, createdBy=9d8a2500148, createdName=ms8888626721583891, createdTime=Sat Aug 18 07:30:00 CST 2012, time=2012-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1346705, encodeId=aa151346e05e3, content=<a href='/topic/show?id=f20155404fc' target=_blank style='color:#2F92EE;'>#抗炎药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55404, encryptionId=f20155404fc, topicName=抗炎药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sat Aug 18 07:30:00 CST 2012, time=2012-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591745, encodeId=80201591e4568, content=<a href='/topic/show?id=90cb415e5f2' target=_blank style='color:#2F92EE;'>#埃索美拉唑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41575, encryptionId=90cb415e5f2, topicName=埃索美拉唑)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=zhangpaul93, createdTime=Sat Aug 18 07:30:00 CST 2012, time=2012-08-18, status=1, ipAttribution=)]
    2012-12-22 dingxiaobo

    #Pharmacol#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1908149, encodeId=1bdf190814944, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Fri Apr 26 08:30:00 CST 2013, time=2013-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787123, encodeId=9bd11e8712395, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Sun Jan 27 13:30:00 CST 2013, time=2013-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995876, encodeId=5c2e19958e6d7, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Wed Oct 17 09:30:00 CST 2012, time=2012-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788140, encodeId=fa491e8814098, content=<a href='/topic/show?id=38e014162e2' target=_blank style='color:#2F92EE;'>#Pharmacol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14162, encryptionId=38e014162e2, topicName=Pharmacol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Sat Dec 22 21:30:00 CST 2012, time=2012-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338684, encodeId=df8b13386846e, content=<a href='/topic/show?id=afff99560c4' target=_blank style='color:#2F92EE;'>#非甾体抗炎药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99560, encryptionId=afff99560c4, topicName=非甾体抗炎药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/7F67E3BE360D6DD1D0A62E3E71E23CB6/100, createdBy=9d8a2500148, createdName=ms8888626721583891, createdTime=Sat Aug 18 07:30:00 CST 2012, time=2012-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1346705, encodeId=aa151346e05e3, content=<a href='/topic/show?id=f20155404fc' target=_blank style='color:#2F92EE;'>#抗炎药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55404, encryptionId=f20155404fc, topicName=抗炎药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sat Aug 18 07:30:00 CST 2012, time=2012-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591745, encodeId=80201591e4568, content=<a href='/topic/show?id=90cb415e5f2' target=_blank style='color:#2F92EE;'>#埃索美拉唑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41575, encryptionId=90cb415e5f2, topicName=埃索美拉唑)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=zhangpaul93, createdTime=Sat Aug 18 07:30:00 CST 2012, time=2012-08-18, status=1, ipAttribution=)]
    2012-08-18 ms8888626721583891

    #非甾体抗炎药#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1908149, encodeId=1bdf190814944, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Fri Apr 26 08:30:00 CST 2013, time=2013-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787123, encodeId=9bd11e8712395, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Sun Jan 27 13:30:00 CST 2013, time=2013-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995876, encodeId=5c2e19958e6d7, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Wed Oct 17 09:30:00 CST 2012, time=2012-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788140, encodeId=fa491e8814098, content=<a href='/topic/show?id=38e014162e2' target=_blank style='color:#2F92EE;'>#Pharmacol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14162, encryptionId=38e014162e2, topicName=Pharmacol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Sat Dec 22 21:30:00 CST 2012, time=2012-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338684, encodeId=df8b13386846e, content=<a href='/topic/show?id=afff99560c4' target=_blank style='color:#2F92EE;'>#非甾体抗炎药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99560, encryptionId=afff99560c4, topicName=非甾体抗炎药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/7F67E3BE360D6DD1D0A62E3E71E23CB6/100, createdBy=9d8a2500148, createdName=ms8888626721583891, createdTime=Sat Aug 18 07:30:00 CST 2012, time=2012-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1346705, encodeId=aa151346e05e3, content=<a href='/topic/show?id=f20155404fc' target=_blank style='color:#2F92EE;'>#抗炎药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55404, encryptionId=f20155404fc, topicName=抗炎药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sat Aug 18 07:30:00 CST 2012, time=2012-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591745, encodeId=80201591e4568, content=<a href='/topic/show?id=90cb415e5f2' target=_blank style='color:#2F92EE;'>#埃索美拉唑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41575, encryptionId=90cb415e5f2, topicName=埃索美拉唑)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=zhangpaul93, createdTime=Sat Aug 18 07:30:00 CST 2012, time=2012-08-18, status=1, ipAttribution=)]
    2012-08-18 xinmeili

    #抗炎药#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1908149, encodeId=1bdf190814944, content=<a href='/topic/show?id=a8d0141605e' target=_blank style='color:#2F92EE;'>#pharma#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14160, encryptionId=a8d0141605e, topicName=pharma)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Fri Apr 26 08:30:00 CST 2013, time=2013-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1787123, encodeId=9bd11e8712395, content=<a href='/topic/show?id=fa03141591e' target=_blank style='color:#2F92EE;'>#Pharm#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14159, encryptionId=fa03141591e, topicName=Pharm)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Sun Jan 27 13:30:00 CST 2013, time=2013-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995876, encodeId=5c2e19958e6d7, content=<a href='/topic/show?id=ed881120ec8' target=_blank style='color:#2F92EE;'>#MAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11207, encryptionId=ed881120ec8, topicName=MAC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Wed Oct 17 09:30:00 CST 2012, time=2012-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788140, encodeId=fa491e8814098, content=<a href='/topic/show?id=38e014162e2' target=_blank style='color:#2F92EE;'>#Pharmacol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14162, encryptionId=38e014162e2, topicName=Pharmacol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Sat Dec 22 21:30:00 CST 2012, time=2012-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338684, encodeId=df8b13386846e, content=<a href='/topic/show?id=afff99560c4' target=_blank style='color:#2F92EE;'>#非甾体抗炎药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99560, encryptionId=afff99560c4, topicName=非甾体抗炎药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/7F67E3BE360D6DD1D0A62E3E71E23CB6/100, createdBy=9d8a2500148, createdName=ms8888626721583891, createdTime=Sat Aug 18 07:30:00 CST 2012, time=2012-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1346705, encodeId=aa151346e05e3, content=<a href='/topic/show?id=f20155404fc' target=_blank style='color:#2F92EE;'>#抗炎药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55404, encryptionId=f20155404fc, topicName=抗炎药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sat Aug 18 07:30:00 CST 2012, time=2012-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591745, encodeId=80201591e4568, content=<a href='/topic/show?id=90cb415e5f2' target=_blank style='color:#2F92EE;'>#埃索美拉唑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41575, encryptionId=90cb415e5f2, topicName=埃索美拉唑)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=zhangpaul93, createdTime=Sat Aug 18 07:30:00 CST 2012, time=2012-08-18, status=1, ipAttribution=)]
    2012-08-18 zhangpaul93

    #埃索美拉唑#

    0