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Materials：掺杂β-TCP作为增强复合β-TCP-无碱生物活性玻璃骨移植再生电位的策略

2018-12-26 MedSci MedSci原创

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本研究旨在评估两种不同摩尔百分比的锶（5,10）和锌（1,2）部分替代可再吸收的β-磷酸三钙（β-TCP）中的钙所带来的潜在收益，同时具有固定摩尔百分比（0.5）的锰。制备由掺杂的β-TCP和无碱生物活性玻璃组成的合成颗粒复合骨填充移植物，并植入在Wistar大鼠的颅骨中钻出的约4mm直径的骨缺损中。植入9周后处死动物并切除颅盖。非操作骨用作阳性对照，而空缺陷用作阴性对照组。 von Kossa染

本研究旨在评估两种不同摩尔百分比的锶（5,10）和锌（1,2）部分替代可再吸收的β-磷酸三钙（β-TCP）中的钙所带来的潜在收益，同时具有固定摩尔百分比（0.5）的锰。

制备由掺杂的β-TCP和无碱生物活性玻璃组成的合成颗粒复合骨填充移植物，并植入在Wistar大鼠的颅骨中钻出的约4mm直径的骨缺损中。植入9周后处死动物并切除颅盖。非操作骨用作阳性对照，而空缺陷用作阴性对照组。

von Kossa染色显示，随着掺杂水平的增加新骨形成增多，支持掺杂元素施加的治疗效果。使用自体骨、BG（之前的结果）或3TCP2/7BG填充骨缺损时，新形成的骨的百分比相似，这表明后两者是替代自体骨作为骨再生材料的极好候选者。

综上所述，该研究结果表明，使用合适剂量的治疗离子掺杂是将骨移植物材料转移到人类生物医学应用中的良好策略。

原始出处：

Ferreira MM, Brito AF, et al., Doping β-TCP as a Strategy for Enhancing the Regenerative Potential of Composite β-TCP-Alkali-Free Bioactive Glass Bone Grafts. Experimental Study in Rats. Materials (Basel). 2018 Dec 20;12(1). pii: E4. doi: 10.3390/ma12010004.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=2005183, encodeId=d97a2005183a9, content=<a href='/topic/show?id=af6e6938483' target=_blank style='color:#2F92EE;'>#生物活性玻璃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69384, encryptionId=af6e6938483, topicName=生物活性玻璃)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Thu Jan 10 05:52:00 CST 2019, time=2019-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667147, encodeId=f0fe166e1474e, content=<a href='/topic/show?id=3dae101809cd' target=_blank style='color:#2F92EE;'>#骨移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101809, encryptionId=3dae101809cd, topicName=骨移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbed26112986, createdName=howi, createdTime=Thu Apr 11 13:52:00 CST 2019, time=2019-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1486579, encodeId=cb5114865e9ba, content=<a href='/topic/show?id=6d5f191e46b' target=_blank style='color:#2F92EE;'>#β-TCP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19174, encryptionId=6d5f191e46b, topicName=β-TCP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25078165150, createdName=showtest, createdTime=Fri Dec 28 09:52:00 CST 2018, time=2018-12-28, status=1, ipAttribution=)]
    2019-01-10 fyxzlh

    #生物活性玻璃#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2005183, encodeId=d97a2005183a9, content=<a href='/topic/show?id=af6e6938483' target=_blank style='color:#2F92EE;'>#生物活性玻璃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69384, encryptionId=af6e6938483, topicName=生物活性玻璃)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Thu Jan 10 05:52:00 CST 2019, time=2019-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667147, encodeId=f0fe166e1474e, content=<a href='/topic/show?id=3dae101809cd' target=_blank style='color:#2F92EE;'>#骨移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101809, encryptionId=3dae101809cd, topicName=骨移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbed26112986, createdName=howi, createdTime=Thu Apr 11 13:52:00 CST 2019, time=2019-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1486579, encodeId=cb5114865e9ba, content=<a href='/topic/show?id=6d5f191e46b' target=_blank style='color:#2F92EE;'>#β-TCP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19174, encryptionId=6d5f191e46b, topicName=β-TCP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25078165150, createdName=showtest, createdTime=Fri Dec 28 09:52:00 CST 2018, time=2018-12-28, status=1, ipAttribution=)]
    2019-04-11 howi

    #骨移植#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2005183, encodeId=d97a2005183a9, content=<a href='/topic/show?id=af6e6938483' target=_blank style='color:#2F92EE;'>#生物活性玻璃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69384, encryptionId=af6e6938483, topicName=生物活性玻璃)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Thu Jan 10 05:52:00 CST 2019, time=2019-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1667147, encodeId=f0fe166e1474e, content=<a href='/topic/show?id=3dae101809cd' target=_blank style='color:#2F92EE;'>#骨移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101809, encryptionId=3dae101809cd, topicName=骨移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbed26112986, createdName=howi, createdTime=Thu Apr 11 13:52:00 CST 2019, time=2019-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1486579, encodeId=cb5114865e9ba, content=<a href='/topic/show?id=6d5f191e46b' target=_blank style='color:#2F92EE;'>#β-TCP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19174, encryptionId=6d5f191e46b, topicName=β-TCP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25078165150, createdName=showtest, createdTime=Fri Dec 28 09:52:00 CST 2018, time=2018-12-28, status=1, ipAttribution=)]
    2018-12-28 showtest

    #β-TCP#

    0