J Dent Res:整合抗菌物质至植入体表面的效果观察

2017-09-21 lishiting MedSci原创

随着关节置换、脊柱外科手术和牙齿种植的数目日益增多,目前急迫需要应对植入体相关感染的方法。除了严格的消毒,还有一种有效的可以预防破坏性并发症的方法就是生产一种新型的具有抗菌特性的植入体。重要的是,这种植入体在牙植入环境中必须具有一定的活性,因为它埋藏在富含糖蛋白的唾液流体中,而富含糖蛋白的唾液可以增强细菌粘附和传播以及生物膜的形成。然而,要设计这样一种抗菌表面,在抗菌活性和需要植入体与骨环境相互作

随着关节置换、脊柱外科手术和牙齿种植的数目日益增多,目前急迫需要应对植入体相关感染的方法。除了严格的消毒,还有一种有效的可以预防破坏性并发症的方法就是生产一种新型的具有抗菌特性的植入体。重要的是,这种植入体在牙植入环境中必须具有一定的活性,因为它埋藏在富含糖蛋白的唾液流体中,而富含糖蛋白的唾液可以增强细菌粘附和传播以及生物膜的形成。然而,要设计这样一种抗菌表面,在抗菌活性和需要植入体与骨环境相互作用之间的平衡必受影响。研究者设计了3种不同类型的表面来对抗生物膜的形成,同时试图维持与骨的相互作用:1) 表面结构通常为纳米级,它可以减少细菌的粘附以此充分减缓感染的建立;2) 表面可以释放活性抗菌物质防止细菌粘附并促进灭菌;3) 表面含有持久的粘接剂可以产生抗菌表面以此避免长期的细菌粘附。结果显示,纳米形态和释放表面在体外均展现出纵然受限但多变的抗菌活性。通过共价偶联,持久的抗菌表面具有杀灭有机体并促进骨整合的能力。然而,所有方法都存在明显的缺点:稳定性差和效力低,但持久的抗菌表面对于创造长期的抗菌环境可能具有一定的优势。原始出处:Hickok NJ, Shapiro IM, et al.

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    2017-10-01 天涯183

    非常好的文章.学习了

    0

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    2017-09-24 天涯183

    非常好的文章.学习了

    0

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    2017-09-24 王晓霞

    学习了

    0

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    2017-09-23 jiyangfei