Ann Rheum Dis:新发类风湿关节炎中的急性冠脉综合征

2017-07-15 xiangting MedSci原创

尽管新发RA患者的疾病控制有所改善,但RA的ACS风险升高仍然是个问题。

急性冠状动脉综合征(ACS)和其他心血管疾病是类风湿性关节炎(RA)发病率和死亡率增加的主要原因。RA中的ACS与炎症和RA严重程度相关。近年来,随着新的治疗方案和治疗对策的出现,有越来越多的努力使得RA在诊断后可以尽快达到缓解,RA疾病活动的平均水平有所下降。这是否会导致RA并发症的风险下降尚不清楚。

研究人员对1997年至2014年新发RA患者进行了一项全国性的人群队列研究,并与一般人群比较。在瑞典医疗保健系统中所有居民均享有均等的保健服务。使用可以联网高质量基于人群的登记来监测医疗保健。从瑞典风湿病质量登记确定了15 744例新发RA患者,以及70 899例一般人群匹配对象。

772例RA患者在103 835人年的随访(粗发病率7.4/1000)中发生ACS,相当于总HR与一般人群比较1.41(95%CI 1.29至1.54)。而在RA和普通人群组中,ACS发病率随时间下降,ACS的过剩和相对风险保持不变。

尽管新发RA患者的疾病控制有所改善,但RA的ACS风险升高仍然是个问题。

原始出处:

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    2017-07-17 lmm397
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    2017-07-15 中医痴

    不错的,学习了,谢谢分享!

    0

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Ann Rheum Dis:RA:生物改善病情抗风湿药有效性的2016年更新系统文献回顾

过去的20年间,类风湿关节炎(RA)的治疗已取得了突破性的进展,其原因之一就是众多新型传统合成改善病情抗风湿药(csDMARD)和生物改善病情抗风湿药(bDMARDs)的研发和涌现。2017年6月,发表在《Ann Rheum Dis》的一项研究旨在更新bDMARDs在RA患者中有效性的证据。

J Rheumatol:患者报告的结果作为早期类风湿关节炎疾病活动变化和残疾的预测因子

患者报告的基线时的疲劳、疼痛和僵硬对于预测RA疾病活动(DAS28)变化和活动受限(HAQ-DI)其价值有限。

Arthritis Rheumatol:早期类风湿关节炎治疗1年后赛妥珠单抗是维持、减量还是停药?

CZP + MTX的标准或降低频率剂量之间没有临床意义上的差异;与CZP停药相比,两者均更有效地控制了类风湿关节炎。