Stroke:颈动脉壁体积进展与复发性短暂性脑缺血发作或卒中的相关性分析!

2018-01-31 xing.T MedSci原创

由此可见,颈动脉壁体积的年度进展与复发性缺血性脑血管事件独立相关,这种指标增加了对斑块内出血和纤维帽破裂的事件预测价值。

近日,卒中领域权威杂志Stroke上发表了一篇研究文章,该研究通过磁共振成像检查旨在探讨颈动脉斑块进展与随后复发事件之间的相关性。

该研究纳入了63例患有同侧颈动脉粥样硬化狭窄(狭窄30%-69%)的患者,在基线和第一次扫描后超过6个月后分别进行第一次和第二次颈动脉磁共振成像来明确颈动脉狭窄。所有患者在第二次磁共振扫描后进行小于5年的临床随访,以确定复发性短暂性脑缺血发作或卒中。研究人员确定了有/无颈动脉斑块的组成特征,特别是斑块内出血和纤维帽破裂。在两次磁共振扫描期间测量了颈动脉壁体积每年进展情况。研究人员采用单因素和多因素Cox回归分析来计算判断复发事件的颈动脉斑块特征风险比和相应的95%置信区间。受试者操作特征曲线分析被用于确定预测复发事件的颈动脉斑块特征曲线下面积。

该研究最终分析纳入了63名患者(平均年龄为66.5±10.0岁; 54名男性)。平均随访55.1±13.6个月,14.3%的患者(n=9)出现同侧复发性短暂性脑缺血发作/卒中。颈动脉壁体积的年度进展与复发事件显著相关,在调整混杂因素之前(风险比为1.14/10mm3; 95%可信区间为1.02-1.27; P=0.019)和之后(风险比为1.19/10mm3; 95%可信区间为1.03-1.37; P=0.022)。在鉴别短暂性脑缺血发作/卒中复发时,受试者操作特征曲线分析显示随着每年的颈动脉壁体积进展,血管壁内出血(曲线下面积为0.69-0.81)和纤维帽破裂(曲线下面积为0.73-0.84)的曲线下面积有所改善。

由此可见,颈动脉壁体积的年度进展与复发性缺血性脑血管事件独立相关,这种指标增加了对斑块内出血和纤维帽破裂的事件预测价值。

原始出处:


Mingming Lu,et al. Association of Progression of Carotid Artery Wall Volume and Recurrent Transient Ischemic Attack or Stroke A Magnetic Resonance Imaging Study.Stroke. 2018. https://doi.org/10.1161/STROKEAHA.117.019422

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    2018-01-31 131****1460

    学习了受益匪浅

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