Nat Rev Clin Oncol：新测试揭开转移性原发癌的真面目！

2017-07-08 枫丹白露来宝网

去年EPICUP表观遗传学测试的发明允许医师阐明在未知原发癌（CUP）患者中转移的原发性肿瘤是什么类型的。今天，表观遗传学和癌症生物学项目的协调员bellvige生物研究所(IDIBELL)ICREA研究员和巴塞罗那大学的遗传学教授Manel Esteller博士在自然评论临床肿瘤学杂志上发表的一篇文章解释说这个测试是如何被转化到临床实践和可以开发的新进展。

去年EPICUP表观遗传学测试的发明允许医师阐明在未知原发癌（CUP）患者中转移的原发性肿瘤是什么类型的。今天，表观遗传学和癌症生物学项目的协调员bellvige生物研究所(IDIBELL)ICREA研究员和巴塞罗那大学的遗传学教授Manel Esteller博士在自然评论临床肿瘤学杂志上发表的一篇文章解释说这个测试是如何被转化到临床实践和可以开发的新进展。

Manel Esteller博士解释说：“传统方法只能检测30%的病例的来历不明的原发肿瘤转移。一些分子方法可以增加这个比例，但他们往往非常昂贵，需要使用分子RNA(核糖核酸)，这是非常脆弱的，往往在医院的病理解剖学中是很容易分解的样品。”

研究者补充道：“EPICUP测试，在另一方面，基于DNA分子，是非常稳定的，所以它可以从所在医院的病人以更简单的方式送到分析实验室。研究结果可以在一周内获得”

未知原发癌（CUP）占检测到转移的人类肿瘤的10％，但是尽管进行了几次探索性试验，但原发性肿瘤不能定位。由于肿瘤类型未知，这些患者的生存率非常低；根据“自然评论临床肿瘤学”中提供的结果，EPICUP测试的实施将导致未来开发更具体的治疗方法。Esteller博士总结说：“现在需要进行前瞻性试验来确定如何正确诊断这些CUP患者可以受益于更具体和更积极的治疗方法。”

原始出处：

Sebastián Moran, Anna Martinez-Cardús, et al. Precision medicine based on epigenomics: the paradigm of carcinoma of unknown primary. Nature Reviews Clinical Oncology (2017) doi:10.1038/nrclinonc.2017.97

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2017-09-24 liye789132251

#Nat#

29 0
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2017-12-02 minlingfeng

#Oncol#

23 0
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2017-07-10 luominglian113

学习了，谢谢分享

46 0
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2017-07-10 1249842em09(暂无昵称)

#转移性#

16 0
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2017-07-10 往日如昨

学习了谢谢分享

54 0
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2017-07-09 flysky120

希望以后能治愈癌症

51 0
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2017-07-09 李东泽

很好，不错，以后会多学习

63 0
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createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Jul 09 08:49:19 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
2017-07-09 Y—xianghai

学习了新知识

46 0
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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220283, encodeId=1295220283cc, content=很好，不错，以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Jul 09 10:49:41 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220269, encodeId=6aa322026970, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Jul 09 09:45:24 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220259, encodeId=ae6b22025996, content=希望对临床诊疗有帮助。, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Sun Jul 09 09:35:18 CST 2017, time=2017-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220242, encodeId=04da22024222, content=学习了受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Jul 09 08:49:19 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
2017-07-09 ren1mw

希望对临床诊疗有帮助。

31 0
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createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Jul 09 08:49:19 CST 2017, time=2017-07-09, status=1, ipAttribution=)]
2017-07-09 131****1460

学习了受益匪浅。

24 0