SCI REP:在高风险自闭症婴儿中预测非典型发育

2017-09-14 海北 MedSci原创

神经生物学特征的变异在发育早期是普遍存在的,但是至今为止,其与人类不良发育之间的联系还是未知的。发育生物学中的一个重要的问题是理解环境信息的早期扰动是否可能导致非正常发育的思维和大脑。

神经生物学特征的变异在发育早期是普遍存在的,但是至今为止,其与人类不良发育之间的联系还是未知的。发育生物学中的一个重要的问题是理解环境信息的早期扰动是否可能导致非正常发育的思维和大脑。 来自哥伦比亚大学的研究人员在71位健康的典型发育的婴儿中,探究了其一岁之前运动中的信号和噪音水平是如何限制早期发育的。这些婴儿被分为自闭症高家庭风险组(HR)和低家庭风险组(LR)。 相对于发育进展较快的HR婴儿以及相对于所有LR组的婴儿,在HR组中,早期学习发展轨迹的延迟(在代表性妊娠相关研究的1,445名婴儿的分析中验证)能够被出生后1-2个月内较差的自发性头部运动随机模式所预测。LR组1-2个月的婴儿在语言听觉任务期间与睡眠期间的运动有显著差异,但在这两种情况下,HR婴儿的运动更为相似,显然缺乏多样性。这揭示了对环境信息不灵活的体验。 与预期相反,早期发育中特别有害的不是本质上的差异性。相反,不灵活的感觉运动系统和/或行为状态之间的非典型转换可能干扰在出生时从感觉输入提取结构和重要线索的能力的建立,并且导致在幼儿期间非典型的脑发育轨迹。 原始出处: Kristina Denisova et al.

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    2017-09-17 1e17414fm02(暂无匿称)

    学习

    0

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    2017-09-15 neurowu
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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5a021728665, createdName=小安安, createdTime=Thu Sep 14 16:34:30 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243853, encodeId=84122438535d, content=高风险自闭症婴儿发育也不正常吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzcjoLTEEgkSSQ8pVIiaf4a4INaoMLBV16QEk3dvvBRpicwIwmDGv0jePErJ4aE9ibVBDPtkialQLT9Bs/0, createdBy=04811949400, createdName=邓启付, createdTime=Thu Sep 14 09:13:39 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243838, encodeId=373b2438389d, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Thu Sep 14 08:23:53 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243824, encodeId=4bf124382424, content=很好.学习了.很有帮助., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Thu Sep 14 07:56:47 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243816, encodeId=1ecc24381658, content=学习一下知识, beContent=null, objectType=article, 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  5. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Thu Sep 14 08:23:53 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243824, encodeId=4bf124382424, content=很好.学习了.很有帮助., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Thu Sep 14 07:56:47 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243816, encodeId=1ecc24381658, content=学习一下知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Thu Sep 14 07:36:13 CST 2017, time=2017-09-14, status=1, ipAttribution=)]
    2017-09-15 xiongke014
  6. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Thu Sep 14 08:23:53 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243824, encodeId=4bf124382424, content=很好.学习了.很有帮助., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Thu Sep 14 07:56:47 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243816, encodeId=1ecc24381658, content=学习一下知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Thu Sep 14 07:36:13 CST 2017, time=2017-09-14, status=1, ipAttribution=)]
    2017-09-14 小安安

    又学到新东西

    0

  7. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Thu Sep 14 08:23:53 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243824, encodeId=4bf124382424, content=很好.学习了.很有帮助., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Thu Sep 14 07:56:47 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243816, encodeId=1ecc24381658, content=学习一下知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Thu Sep 14 07:36:13 CST 2017, time=2017-09-14, status=1, ipAttribution=)]
    2017-09-14 邓启付

    高风险自闭症婴儿发育也不正常吗

    0

  8. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5a021728665, createdName=小安安, createdTime=Thu Sep 14 16:34:30 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243853, encodeId=84122438535d, content=高风险自闭症婴儿发育也不正常吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzcjoLTEEgkSSQ8pVIiaf4a4INaoMLBV16QEk3dvvBRpicwIwmDGv0jePErJ4aE9ibVBDPtkialQLT9Bs/0, createdBy=04811949400, createdName=邓启付, createdTime=Thu Sep 14 09:13:39 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243838, encodeId=373b2438389d, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Thu Sep 14 08:23:53 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243824, encodeId=4bf124382424, content=很好.学习了.很有帮助., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Thu Sep 14 07:56:47 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243816, encodeId=1ecc24381658, content=学习一下知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Thu Sep 14 07:36:13 CST 2017, time=2017-09-14, status=1, ipAttribution=)]
    2017-09-14 九九消寒

    优质资源.共同学习

    0

  9. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5a021728665, createdName=小安安, createdTime=Thu Sep 14 16:34:30 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243853, encodeId=84122438535d, content=高风险自闭症婴儿发育也不正常吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzcjoLTEEgkSSQ8pVIiaf4a4INaoMLBV16QEk3dvvBRpicwIwmDGv0jePErJ4aE9ibVBDPtkialQLT9Bs/0, createdBy=04811949400, createdName=邓启付, createdTime=Thu Sep 14 09:13:39 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243838, encodeId=373b2438389d, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Thu Sep 14 08:23:53 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243824, encodeId=4bf124382424, content=很好.学习了.很有帮助., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Thu Sep 14 07:56:47 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243816, encodeId=1ecc24381658, content=学习一下知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Thu Sep 14 07:36:13 CST 2017, time=2017-09-14, status=1, ipAttribution=)]
    2017-09-14 李东泽

    很好.学习了.很有帮助.

    0

  10. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Thu Sep 14 08:23:53 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243824, encodeId=4bf124382424, content=很好.学习了.很有帮助., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Thu Sep 14 07:56:47 CST 2017, time=2017-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243816, encodeId=1ecc24381658, content=学习一下知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Thu Sep 14 07:36:13 CST 2017, time=2017-09-14, status=1, ipAttribution=)]
    2017-09-14 flysky120

    学习一下知识

    0

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来自伊利诺伊大学的一项新研究结果表明,某些肠道细菌和大脑代谢物之间存在着一种沟通途径,这种途径是通过一种名为皮质醇的血液化合物来实现的。出乎意料的是,这一发现提供了一种解释自闭症特征的潜在机制。

Gut Microbes:解释自闭症形成潜在机制

肠道微生物最近经常在新闻中出现。最近的研究表明它们可以影响人类的健康、行为以及某些某些神经系统疾病,如自闭症。但是它们是如何与大脑交流的呢?伊利诺伊大学的一项新研究的结果表明,某些肠道细菌和大脑代谢物之间通过一种称为皮质醇的化合物形成通路。出乎意料的是,这个发现解释了自闭症形成的潜在机制。

盘点:自闭症近期重要研究汇总

自闭症又称孤独症,是一种发育障碍类疾病。患者生活基本不能自理,可能需要持续一生的治疗。到目前为止,人们还没有找到可以治愈自闭症的药物。自闭症已经成为儿童精神类致残的重要疾病,随着发病率的持续升高,自闭症患儿让无数家庭为之焦心。这里梅斯小编整理了近期关于自闭症的重要研究进展与大家一同分享。【1】孕期疱疹新生儿会患自闭症近日,一项新研究显示,单纯性疱疹病毒Ⅱ型(HSV-2)感染可能导致自闭症。科学家发

JAMA Psychiatry:线粒体变异增加自闭症风险

自闭症患者在社会互动,交流,和重复或限制性行为等方面会出现障碍。多篇生理以及生化研究已经报导了自闭症患者线粒体氧化磷酸化的缺陷,但是至今为止,线粒体DNA的变异对自闭症的影响还没有被报导。

Curr Bio:由打哈欠引出的神经疾病治疗新思路

看见别人打哈欠,自己是不是也会不由自主地打哈欠呢?然后你会好奇:打哈欠会传染吗?为什么?最近,来自于诺丁汉大学的科学家们发现,这种传染性行为源于大脑控制运动机能的特定区域——初级运动皮质层的“原始反射”。这种本能的冲动程度受皮质兴奋性控制。

Gut Microbes:科学家揭秘:肠道微生物是如何与大脑交流的

来自伊利诺伊大学的一项新研究结果表明,某些肠道细菌和大脑代谢物之间存在着一种沟通途径,这种途径是通过一种名为皮质醇的血液化合物来实现的。出乎意料的是,这一发现提供了一种解释自闭症特征的潜在机制。