Lasers Med Sci:低强度激光治疗与阴离子聚合物膜联合应用可有效恢复骨丧失

2019-08-30 不详 网络

鉴于使用自体移植物作为金标准的骨重建手术的局限性,组织工程作为替代方案正在出现,其允许制造和改进支架以刺激骨生成和血管生成,这是骨修复所必需的过程。聚合物用于模拟细胞外骨基质并支持细胞生长。此外,骨骼新生成可以通过外部因素诱导,例如激光照射,其刺激骨代谢。本研究旨在评估骨缺损的再生,使用来自肠浆膜和牛耳软骨的胶原蛋白和弹性蛋白膜结合低水平激光应用。选择36只Wistar大鼠,在左股骨的远端干骺端产

鉴于使用自体移植物作为金标准的骨重建手术的局限性,组织工程作为替代方案正在出现,其允许制造和改进支架以刺激骨生成和血管生成,这是骨修复所必需的过程。聚合物用于模拟细胞外骨基质并支持细胞生长。此外,骨骼新生成可以通过外部因素诱导,例如激光照射,其刺激骨代谢。本研究旨在评估骨缺损的再生,使用来自肠浆膜和牛耳软骨的胶原蛋白和弹性蛋白膜结合低水平激光应用。

选择36只Wistar大鼠,在左股骨的远端干骺端产生3mm缺损并分成六组:G1(对照,无治疗); G2(激光); G3(弹性蛋白移植物),G4(弹性蛋白+激光); G5(胶原移植物); G6(胶原蛋白+激光)。手术后6周处死动物,取出股骨进行骨修复分析。宏观和放射学结果显示手术区域没有感染过程。这通过组织学分析证实,其显示没有炎性浸润。组织形态学表明,新骨的形成始于骨缺损的边缘,其弹性蛋白+激光和胶原+激光的体积更大。

总之,该研究结果表明,在接受生物材料和激光的组中,移植区域中新形成的骨骼较高。胶原蛋白和弹性蛋白基质显示出生物相容性。

原始出处:

Dos Santos DA, de Guzzi Plepis AM, et al., Effects of the combination of low-level laser therapy and anionic polymer membranes on bone repair. Lasers Med Sci. 2019 Aug 29. doi: 10.1007/s10103-019-02864-8.

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    2020-04-07 mei543
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    2020-02-23 hyf028
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    2020-07-04 anminleiryan
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    2019-09-01 oliver169
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    2019-09-01 yese
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