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PI3K抑制剂局部给药可防治急性肺损伤

2011-10-09 MedSci原创 MedSci原创

肺损伤PI3K
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　磷脂酰肌醇3激酶（PI3K）可能是肺损伤的治疗靶点之一，局部应用PI3K抑制剂可能是肺损伤最佳治疗方法之一。 　　在气管内滴入脂多糖之前，通过鼻内和胃内途径对小鼠应用不同的PI3K抑制剂（1次/日，连用3天）。结果为，局部应用PI3K抑制剂预防内毒素诱导肺损伤的效果优于全身应用。不同PI3K抑制剂预防肺损伤效果不同,最可能原因为化学性质、靶位和药代动力学差异。在小鼠和大鼠中，局部应用 PI3K

　磷脂酰肌醇3激酶（PI3K）可能是肺损伤的治疗靶点之一，局部应用PI3K抑制剂可能是肺损伤最佳治疗方法之一。

　　在气管内滴入脂多糖之前，通过鼻内和胃内途径对小鼠应用不同的PI3K抑制剂（1次/日，连用3天）。结果为，局部应用PI3K抑制剂预防内毒素诱导肺损伤的效果优于全身应用。不同PI3K抑制剂预防肺损伤效果不同,最可能原因为化学性质、靶位和药代动力学差异。在小鼠和大鼠中，局部应用 PI3K抑制剂既可预防内毒素所致肺损伤又可预防弹力蛋白酶诱导的肺损伤。

MedSci注：目前国际上对PI3K抑制剂的研究正在开始，有望成为重要的临床用药之一，大家可以重视起来，并可以开展这方面的研究。

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    2012-06-09 jklm09

    #抑制剂#

    0

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    2011-10-11 ms1292405679162969

    #PI3K#

    0

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    2011-10-11 ms6323715314570549

    #急性肺损伤#

    0

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    2011-10-11 智者为医08

    #损伤#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1851074, encodeId=dff918510e466, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Sat Jun 09 19:19:00 CST 2012, time=2012-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333178, encodeId=29b213331e8d5, content=<a href='/topic/show?id=ecfa1423117' target=_blank style='color:#2F92EE;'>#PI3K#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14231, encryptionId=ecfa1423117, topicName=PI3K)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/BF4BC9769C2FF12AC93CAA0069C0696C/100, createdBy=7bb22500091, createdName=ms1292405679162969, createdTime=Tue Oct 11 11:19:00 CST 2011, time=2011-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395389, encodeId=36631395389b9, content=<a href='/topic/show?id=d051523897d' target=_blank style='color:#2F92EE;'>#急性肺损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52389, encryptionId=d051523897d, topicName=急性肺损伤)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/B41263AF328B0A74CD1BA5216160E938/100, createdBy=20992500196, createdName=ms6323715314570549, createdTime=Tue Oct 11 11:19:00 CST 2011, time=2011-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396665, encodeId=fe211396665fd, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Tue Oct 11 11:19:00 CST 2011, time=2011-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405621, encodeId=113e1405621b9, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Tue Oct 11 11:19:00 CST 2011, time=2011-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503291, encodeId=42101503291f9, content=<a href='/topic/show?id=67a7821250e' target=_blank style='color:#2F92EE;'>#肺损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82125, encryptionId=67a7821250e, topicName=肺损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=05329610584, createdName=tastas, createdTime=Tue Oct 11 11:19:00 CST 2011, time=2011-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536875, encodeId=833715368e564, content=<a href='/topic/show?id=37121425067' target=_blank style='color:#2F92EE;'>#PI3K抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14250, encryptionId=37121425067, topicName=PI3K抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=477612737263, createdName=bbjsj_1983, createdTime=Tue Oct 11 11:19:00 CST 2011, time=2011-10-11, status=1, ipAttribution=)]
    2011-10-11 chg122

    #局部#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1851074, encodeId=dff918510e466, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Sat Jun 09 19:19:00 CST 2012, time=2012-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333178, encodeId=29b213331e8d5, content=<a href='/topic/show?id=ecfa1423117' target=_blank style='color:#2F92EE;'>#PI3K#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14231, encryptionId=ecfa1423117, topicName=PI3K)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/BF4BC9769C2FF12AC93CAA0069C0696C/100, createdBy=7bb22500091, createdName=ms1292405679162969, createdTime=Tue Oct 11 11:19:00 CST 2011, time=2011-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395389, encodeId=36631395389b9, content=<a href='/topic/show?id=d051523897d' target=_blank style='color:#2F92EE;'>#急性肺损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52389, encryptionId=d051523897d, topicName=急性肺损伤)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/B41263AF328B0A74CD1BA5216160E938/100, createdBy=20992500196, createdName=ms6323715314570549, createdTime=Tue Oct 11 11:19:00 CST 2011, time=2011-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396665, encodeId=fe211396665fd, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Tue Oct 11 11:19:00 CST 2011, time=2011-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405621, encodeId=113e1405621b9, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Tue Oct 11 11:19:00 CST 2011, time=2011-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503291, encodeId=42101503291f9, content=<a href='/topic/show?id=67a7821250e' target=_blank style='color:#2F92EE;'>#肺损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82125, encryptionId=67a7821250e, topicName=肺损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=05329610584, createdName=tastas, createdTime=Tue Oct 11 11:19:00 CST 2011, time=2011-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536875, encodeId=833715368e564, content=<a href='/topic/show?id=37121425067' target=_blank style='color:#2F92EE;'>#PI3K抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14250, encryptionId=37121425067, topicName=PI3K抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=477612737263, createdName=bbjsj_1983, createdTime=Tue Oct 11 11:19:00 CST 2011, time=2011-10-11, status=1, ipAttribution=)]
    2011-10-11 tastas

    #肺损伤#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1851074, encodeId=dff918510e466, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Sat Jun 09 19:19:00 CST 2012, time=2012-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333178, encodeId=29b213331e8d5, content=<a href='/topic/show?id=ecfa1423117' target=_blank style='color:#2F92EE;'>#PI3K#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14231, encryptionId=ecfa1423117, topicName=PI3K)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/BF4BC9769C2FF12AC93CAA0069C0696C/100, createdBy=7bb22500091, createdName=ms1292405679162969, createdTime=Tue Oct 11 11:19:00 CST 2011, time=2011-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395389, encodeId=36631395389b9, content=<a href='/topic/show?id=d051523897d' target=_blank style='color:#2F92EE;'>#急性肺损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52389, encryptionId=d051523897d, topicName=急性肺损伤)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/B41263AF328B0A74CD1BA5216160E938/100, createdBy=20992500196, createdName=ms6323715314570549, createdTime=Tue Oct 11 11:19:00 CST 2011, time=2011-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1396665, encodeId=fe211396665fd, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Tue Oct 11 11:19:00 CST 2011, time=2011-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1405621, encodeId=113e1405621b9, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Tue Oct 11 11:19:00 CST 2011, time=2011-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503291, encodeId=42101503291f9, content=<a href='/topic/show?id=67a7821250e' target=_blank style='color:#2F92EE;'>#肺损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82125, encryptionId=67a7821250e, topicName=肺损伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=05329610584, createdName=tastas, createdTime=Tue Oct 11 11:19:00 CST 2011, time=2011-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536875, encodeId=833715368e564, content=<a href='/topic/show?id=37121425067' target=_blank style='color:#2F92EE;'>#PI3K抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14250, encryptionId=37121425067, topicName=PI3K抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=477612737263, createdName=bbjsj_1983, createdTime=Tue Oct 11 11:19:00 CST 2011, time=2011-10-11, status=1, ipAttribution=)]
    2011-10-11 bbjsj_1983

    #PI3K抑制剂#

    0