Alzheimers & Dementia:多领域生活方式干预(Finger)中坚持对认知的影响

2021-11-04 Naomii MedSci原创

多领域生活方式的改变有益于认知功能,但未来的干预应该足够密集,支持坚持是必不可少的。

      健康的生活方式与较低的认知障碍风险有关,包括痴呆症和阿尔茨海默病。来自随机对照试验的新证据表明,生活方式干预可能会降低认知障碍的风险。鉴于老年认知障碍的多因素性质,多领域干预是一种很有前途的预防策略。

      坚持生活方式干预是对认知产生影响的关键;不仅要参与建议的活动,而且要在日常生活中采用健康的生活方式。何种生活方式干预仍不清楚。尽管一些旨在预防认知衰退的生活方式试验报告参加了干预或改变生活方式,但很少有研究调查坚持如何影响认知结果,并指出存在正相关。了解所需干预活动的规模将提高未来试验的效果。

      芬兰老年干预及预防认知损害和残疾研究(Finger)是第一个大型多领域生活方式试验,报告了对老年人认知功能的有益影响。近日,有研究人员调查了干预依从性如何影响认知变化(预先指定的分组分析)。分析检查依从性定义为(1)参与干预活动和(2)在为期2年的干预期间实现生活方式的改变。

Finger是一项多中心随机对照试验,检验多领域生活方式干预的有效性(ClinicalTrials.gov NCT01041989)。

      共有1260名年龄在60岁到77岁之间、痴呆症风险增加的参与者被随机分为生活方式干预组和对照组。完成干预疗程的百分比,以及多领域生活方式得分(自我报告饮食;体力、认知和社会活动;血管风险)的变化与神经心理测试组合(NTB)得分变化的关系被检查。

  • 积极参与与NTB总分和所有认知亚域中较好的运动轨迹相关。
  • 生活方式的改善与NTB总量和执行功能的改善有关。 

多领域生活方式的改变有益于认知功能,但未来的干预应该足够密集,支持坚持是必不可少的。

 文献来源:https://alz-journals-onlinelibrary-wiley-com.washington.80599.net/doi/10.1002/alz.12492

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    2022-09-13 anminleiryan
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    2021-11-05 查查佳佳

    默里大学下属的非营利组织DRIVE(Drug

    0

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    2021-11-04 1478fcfem77暂无昵称

    学习了。

    0

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    2021-11-04 denglimoxiaoran

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