Lancet Psychiatry:电惊厥治疗不会增加重症情绪障碍患者后续痴呆风险

2018-03-07 zhangfan MedSci原创

研究认为,对于情绪障碍患者,接受电惊厥治疗不会导致后续痴呆风险增加,对于包括老年患者在内的重症情绪障碍患者而言,电惊厥治疗是安全的

电惊厥治疗(ECT)是治疗情绪障碍的最有效方法,会导致患者暂时性记忆减退,但尚无明确的ECT治疗对患者认知长期影响的报道。近日研究人员对ECT与继发性痴呆的相关性进行考察。

10岁以上因情感障碍首次接受住院治疗的患者参与研究,随访过程中记录患者痴呆的发生率,痴呆诊断的依据为出院诊断或使用乙酰胆碱酯酶抑制剂。对社会人口学和临床变量进行多重调整,采用倾向评分匹配的Cox回归分析考察ECT与痴呆的相关性。

168015名患者参与研究,其中5901人(3.5%)接受至少1次ECT。平均随访4.9年,在872874个患者年中,99045名10-49岁患者中111人确诊痴呆(0.1%),35945名50-69岁患者中965人确诊痴呆(2.7%),33025名70-108岁患者中,4128人确诊痴呆(12.5%)。5901名接受ECT患者中,217人确诊痴呆(3.6%),而162114名未接受ECT患者中,4987人(3.1%)确诊痴呆,每10000患者年的痴呆发病分别为70.4例和59.2例。对于50岁以下以及50-69岁人群,ECT治疗与后续痴呆无关;对于70岁以上人群中,ECT治疗降低痴呆风险。31754人在随访期间死亡,补充分析表明,在调整死亡风险后,ECT治疗与痴呆风险增加不相关。

研究认为,对于情绪障碍患者,接受电惊厥治疗不会导致后续痴呆风险增加,对于包括老年患者在内的重症情绪障碍患者而言,电惊厥治疗是安全的。

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    2018-10-08 howi
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  4. [GetPortalCommentsPageByObjectIdResponse(id=1792114, encodeId=72ac1e92114e2, content=<a href='/topic/show?id=696a14818df' target=_blank style='color:#2F92EE;'>#Psychiatry#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14818, encryptionId=696a14818df, topicName=Psychiatry)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Wed Jul 25 01:46:00 CST 2018, time=2018-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1829522, encodeId=ce901829522b9, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Mon Oct 08 21:46:00 CST 2018, time=2018-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1688243, encodeId=6f28168824371, content=<a href='/topic/show?id=5d5553155d7' target=_blank style='color:#2F92EE;'>#情绪障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53155, encryptionId=5d5553155d7, topicName=情绪障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ba828506031, createdName=ms1065684921169360, createdTime=Thu Feb 07 23:46:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294698, encodeId=2a992946982c, content=一起学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Sat Mar 10 06:31:55 CST 2018, time=2018-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294408, encodeId=20c42944084c, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Fri Mar 09 06:55:41 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316697, encodeId=a34f131669e45, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Fri Mar 09 00:46:00 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1425880, encodeId=2184142588018, content=<a href='/topic/show?id=83135316192' target=_blank style='color:#2F92EE;'>#惊厥#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53161, encryptionId=83135316192, topicName=惊厥)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ff14003523, createdName=zz12341235, createdTime=Fri Mar 09 00:46:00 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=294037, encodeId=abfe29403efc, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Thu Mar 08 06:38:39 CST 2018, time=2018-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293823, encodeId=1ef1293823b9, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/fhZdOu27e88Voqh19n8eF8cLplo8L4nicKtH0WnE3KFELXns5XDu8rsiceK2HHDZc2SEStia5VV3Pia2QLMVqlWbHw/0, createdBy=6e012139475, createdName=神功盖世, createdTime=Wed Mar 07 10:31:47 CST 2018, time=2018-03-07, status=1, ipAttribution=)]
    2018-03-10 wzb521zf

    一起学习学习学习

    0

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    2018-03-09 wzb521zf

    一起学习学习

    0

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    2018-03-09 zz12341235
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    2018-03-08 wzb521zf

    一起学习学习

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    2018-03-07 神功盖世

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