Lancet:滑雪遇雪崩,导致负压性肺水肿——案例报道

2016-11-10 MedSci MedSci原创

患者男,31岁,海拔2500米处滑雪时遇雪崩,被埋葬在雪下,3-5分钟后被朋友们从雪里营救出来。据当事人称,患者的头被雪埋了超过0.5米。患者没有意识丧失,他记得整个营救过程,但无法呼吸,因为雪已经阻塞了他的呼吸道。当脸露出来后,显示紫绀,但患者有意识,并自己清理呼吸道。 12分钟后直升机紧急救援队到达,发现患者存在外周和中枢性紫绀、气促、咯血。患者否认雪下面有任何岩石或物体。创伤生命支持体

患者男,31岁,海拔2500米处滑雪时遇雪崩,被埋在雪下,3-5分钟后被朋友们从雪里营救出来。据当事人称,患者的头部被雪埋了超过0.5米。患者没有意识丧失,记得整个营救过程,但无法呼吸,因为雪已经阻塞了他的呼吸道。露出脸来后,显示紫绀,但患者有意识,并可以自己清理呼吸道。

12分钟后直升机紧急救援队到达,发现患者存在外周和中枢性紫绀、气促、咯血。患者否认雪下面有任何岩石或物体。创伤生命支持检查显示没有其他伤害,患者也否认胸部挤压性疼痛。口腔检查显示无伤口出血,肺部听诊显示双侧湿啰音。立即予以面罩吸氧(吸氧浓度100%)。直升机送患者到瑞士萨梅丹当地医院急救部(海拔1720米)就诊。

在入院时,患者的氧饱和度为93%(吸氧浓度100%),心率和血压正常。CT扫描没有发现创伤等迹象,但有双侧弥漫性肺水肿。




常规实验室检查结果均正常(包括血红蛋白、B型利钠肽和肌钙蛋白水平)。

怀疑是负压性肺水肿伴肺出血,转入ICU进行间歇性无创通气支持疗法。

入院后1天,咯血停止,血红蛋白从入院时168 g/L降到135 g/L。病人迅速康复,并于第4天出院。

事故后4周,进行肺功能试验和超声心动图检查均正常。

5个星期后,患者成功地爬上了钦博拉索山(厄瓜多尔中部),一座高6267米的厄瓜多尔火山。

负压性肺水肿(NPPE)又称为梗阻后肺水肿(POPE)或喉痉挛引发的肺水肿(LIPE),是因病人胸腔内或/和跨肺负压的绝对值增大导致肺泡毛细血管损伤而引发的非心源性肺水肿。

由于成人NPPE产生的最常见的原因是气管插管时或全身麻醉拔管后喉痉挛所引起的上呼吸道梗阻,几乎占到50%,所以不少人认为NPPE是一种麻醉并发症,应引起麻醉科医师的高度重视。

其他原因还包括窒息、会厌炎、异物、甲状腺功能减退、浓缩气管分泌物、呃逆、甲状腺肿、上气道及纵隔肿瘤、肥胖、阻塞性睡眠呼吸暂停、口咽部手术等。

目前的研究提示,NPPE的病理生理学变化包括三个以下方面:较大胸腔内负压产生导致心脏前负荷增加;体循环血压增加引起心脏后负荷增加;肺泡一毛细血管膜应力衰竭。

诊断主要基于上呼吸道梗阻的病史,梗阻解除后数分钟或数小时内突然发生呼吸困难、呼吸增快、缺氧、高碳酸血症、解除梗阻后气道内出现粉红色泡沫样分泌物,影像学上存在增宽的血管影以及双侧的、中心性肺泡和间质的浸润征。

治疗则较简单,存在喉痉挛时可使用正压通气。

原始出处:

Paolo Glisenti,et al. Negative pressure pulmonary oedema with haemorrhage after 5-minute avalanche burial. Lancet.05 November 2016.

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    2017-02-11 howi
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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEKJtqC6MEyItFUhsicbHLNTpicWaE6nx3QyIX0otTfAe10erLyEmSqo4pRmak0byqtbrrGCLdh5tR2g/0, createdBy=87451701570, createdName=好医生向大医精诚努力, createdTime=Fri Nov 11 05:16:34 CST 2016, time=2016-11-11, status=1, ipAttribution=)]
  4. 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channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Nov 11 19:35:07 CST 2016, time=2016-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155093, encodeId=714e1550937b, content=个案报道, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Nov 11 19:34:19 CST 2016, time=2016-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154956, encodeId=189915495643, content=这个。。。就像河北落井小孩一样, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEKJtqC6MEyItFUhsicbHLNTpicWaE6nx3QyIX0otTfAe10erLyEmSqo4pRmak0byqtbrrGCLdh5tR2g/0, createdBy=87451701570, createdName=好医生向大医精诚努力, createdTime=Fri Nov 11 05:16:34 CST 2016, time=2016-11-11, status=1, ipAttribution=)]
    2016-11-12 小华子
  5. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEKJtqC6MEyItFUhsicbHLNTpicWaE6nx3QyIX0otTfAe10erLyEmSqo4pRmak0byqtbrrGCLdh5tR2g/0, createdBy=87451701570, createdName=好医生向大医精诚努力, createdTime=Fri Nov 11 05:16:34 CST 2016, time=2016-11-11, status=1, ipAttribution=)]
    2016-11-11 忠诚向上

    好好学习

    0

  6. 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channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Nov 11 19:35:07 CST 2016, time=2016-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155093, encodeId=714e1550937b, content=个案报道, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Nov 11 19:34:19 CST 2016, time=2016-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154956, encodeId=189915495643, content=这个。。。就像河北落井小孩一样, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Nov 11 08:19:20 CST 2016, time=2016-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154913, encodeId=da44154913c5, content=学习新知识谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Fri Nov 11 05:29:10 CST 2016, time=2016-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154910, encodeId=f5a015491063, content=不错的,需要加油, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEKJtqC6MEyItFUhsicbHLNTpicWaE6nx3QyIX0otTfAe10erLyEmSqo4pRmak0byqtbrrGCLdh5tR2g/0, createdBy=87451701570, createdName=好医生向大医精诚努力, createdTime=Fri Nov 11 05:16:34 CST 2016, time=2016-11-11, status=1, ipAttribution=)]
    2016-11-11 老段

    不错的个案分析

    0

  7. 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channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Nov 11 19:35:07 CST 2016, time=2016-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155093, encodeId=714e1550937b, content=个案报道, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Nov 11 19:34:19 CST 2016, time=2016-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154956, encodeId=189915495643, content=这个。。。就像河北落井小孩一样, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEKJtqC6MEyItFUhsicbHLNTpicWaE6nx3QyIX0otTfAe10erLyEmSqo4pRmak0byqtbrrGCLdh5tR2g/0, createdBy=87451701570, createdName=好医生向大医精诚努力, createdTime=Fri Nov 11 05:16:34 CST 2016, time=2016-11-11, status=1, ipAttribution=)]
    2016-11-11 老段

    个案报道

    0

  8. 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channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Nov 11 19:35:07 CST 2016, time=2016-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155093, encodeId=714e1550937b, content=个案报道, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Nov 11 19:34:19 CST 2016, time=2016-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154956, encodeId=189915495643, content=这个。。。就像河北落井小孩一样, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEKJtqC6MEyItFUhsicbHLNTpicWaE6nx3QyIX0otTfAe10erLyEmSqo4pRmak0byqtbrrGCLdh5tR2g/0, createdBy=87451701570, createdName=好医生向大医精诚努力, createdTime=Fri Nov 11 05:16:34 CST 2016, time=2016-11-11, status=1, ipAttribution=)]
    2016-11-11 明月清辉

    这个。。。就像河北落井小孩一样

    0

  9. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEKJtqC6MEyItFUhsicbHLNTpicWaE6nx3QyIX0otTfAe10erLyEmSqo4pRmak0byqtbrrGCLdh5tR2g/0, createdBy=87451701570, createdName=好医生向大医精诚努力, createdTime=Fri Nov 11 05:16:34 CST 2016, time=2016-11-11, status=1, ipAttribution=)]
    2016-11-11 刘煜

    学习新知识谢谢分享。

    0

  10. 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channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Nov 11 19:35:07 CST 2016, time=2016-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155093, encodeId=714e1550937b, content=个案报道, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Nov 11 19:34:19 CST 2016, time=2016-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154956, encodeId=189915495643, content=这个。。。就像河北落井小孩一样, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Nov 11 08:19:20 CST 2016, time=2016-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154913, encodeId=da44154913c5, content=学习新知识谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Fri Nov 11 05:29:10 CST 2016, time=2016-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=154910, encodeId=f5a015491063, content=不错的,需要加油, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEKJtqC6MEyItFUhsicbHLNTpicWaE6nx3QyIX0otTfAe10erLyEmSqo4pRmak0byqtbrrGCLdh5tR2g/0, createdBy=87451701570, createdName=好医生向大医精诚努力, createdTime=Fri Nov 11 05:16:34 CST 2016, time=2016-11-11, status=1, ipAttribution=)]
    2016-11-11 好医生向大医精诚努力

    不错的,需要加油

    0