Nat Med:癌症患者的自杀风险和死亡率

2022-04-02 MedSci原创 MedSci原创

癌症患者,尤其是具有特定风险因素的患者,应密切监测其自杀倾向,并需要专门护理以降低短期和长期自杀风险。

抑郁的发生率和流行率随着年龄增加而增加。如果不予适当治疗,抑郁将增加残疾、患病和死亡的风险。癌症患者中抑郁尤其高发,且影响预后。老年癌症患者中抑郁更加常见和严重。实际上,老年患者的自杀风险通常难以识别。绝大部分抑郁患者没有得到恰当诊断和治疗。癌症治疗,包括化疗和放疗,尽管近几十年来癌症治疗取得了重大进展,但癌症患者短期和长期的自杀风险仍然很高。个别研究的数据尚未得到全面量化,其具体的风险因素也并不明确。

近日,顶级医学期刊Nature Medicine上发表了一篇研究文章,研究人员根据癌症预后、分期、癌症诊断的时间、患者性别、种族、婚姻状况、招募年份和地理区域评估了癌症患者的自杀死亡风险。

研究人员在EMBASE、MEDLINE、PsycINFO、WebofScience、CINAHL和GoogleScholar中检索了截至2021年2月的相关文章。研究人员使用随机效应模型进行荟萃回归分析,并使用I²、漏斗图和Egger和Begg进行检验。研究人员进行了系统评价,纳入了62项研究和46952813名患者。为避免患者样本重叠,研究人员对28项研究进行了荟萃分析,涉及22407690名癌症患者。

研究人员发现与一般人群相比,癌症患者自杀死亡率显著增加(标准化死亡率=1.85,95%置信区间=1.55-2.20)。风险与癌症预后、癌症分期、诊断时间和地理区域密切相关。

由此可见,癌症患者,尤其是具有特定风险因素的患者,应密切监测其自杀倾向,并需要专门护理以降低短期和长期自杀风险。

 

原始出处:

Michael Heinrich,et al.Suicide risk and mortality among patients with cancer.Nature Medicine.2022.https://www.nature.com/articles/s41591-022-01745-y.

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    2022-06-29 liye789132251
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    2022-10-01 ms4000001708646284

    所以要提高医院的人文环境

    0

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