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Neurology：静脉成形术在MS患者中的安全性和疗效

2018-10-01 xing.T MedSci原创

静脉成形术MS安全性疗效
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由此可见，该数据不支持持续使用颅外颈静脉和/或静脉静脉狭窄的静脉成形术来改善患者报告的结局、慢性MS症状或MS病程。

近日，神经病学领域权威取杂志Neurology上发表了一篇研究文章，研究人员旨在明确球囊与假性静脉成形术治疗多发性硬化症（MS）中颅外颈静脉和奇静脉狭窄的安全性和疗效。

研究人员采用临床和超声标准筛查了复发或进展型MS患者。通过静脉造影确认狭窄>50％，参与者以1：1随机分组对所有狭窄进行球囊或假静脉成形术，并随访48周。参与者和研究人员对干预分配不知情。主要安全性结局为48周内不良事件（AEs）的数量。主要疗效结局是患者报告的结果MS 生活质量-54（MSQOL-54）问卷得分从基线到第48周的变化。研究人员还评估了标准化的临床和MRI结局。

研究人员随机选择了104名参与者（55名假手术患者; 49名静脉成形术患者），103名患者完成了48周的随访。23名假手术患者和21名静脉成形术患者报告至少发生1个AE；1名假手术患者（2％）和5名（10％）静脉成形术患者有严重的AE。 MSQOL-54身体评分的平均改善为1.3（假手术组）和1.4（静脉成形术组）（p=0.95）; MSQOL-54心理评分为1.2（假手术组）和-0.8（静脉成形术组）（p=0.55）。

由此可见，该数据不支持持续使用颅外颈静脉和/或静脉静脉狭窄的静脉成形术来改善患者报告的结局、慢性MS症状或MS病程。

原始出处：

Anthony L. Traboulsee, et al. Safety and efficacy of venoplasty in MS A randomized, double-blind, sham-controlled, phase II trial.neurology.2018. http://n.neurology.org/content/early/2018/09/28/WNL.0000000000006423

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    2019-01-23 yinhl1978

    #Neurol#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2000596, encodeId=a498200059671, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Jan 23 12:32:00 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819052, encodeId=a41518190527a, content=<a href='/topic/show?id=e3ba99123ec' target=_blank style='color:#2F92EE;'>#静脉成形术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99123, encryptionId=e3ba99123ec, topicName=静脉成形术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=226a143, createdName=cathymary, createdTime=Fri Jul 05 02:32:00 CST 2019, time=2019-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697770, encodeId=423a169e77077, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Tue Apr 23 01:32:00 CST 2019, time=2019-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2004702, encodeId=c52d2004e02be, content=<a href='/topic/show?id=4e8a5400816' target=_blank style='color:#2F92EE;'>#成形术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54008, encryptionId=4e8a5400816, topicName=成形术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fb6449, createdName=ZGMFX24A, createdTime=Mon Dec 17 00:32:00 CST 2018, time=2018-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031925, encodeId=5b0f1031925b0, content=谢谢梅斯提供这么好的信息，学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Mon Oct 01 13:32:00 CST 2018, time=2018-10-01, status=1, ipAttribution=)]
    2019-07-05 cathymary

    #静脉成形术#

    0

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    2019-04-23 fusion

    #静脉#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2000596, encodeId=a498200059671, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Jan 23 12:32:00 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819052, encodeId=a41518190527a, content=<a href='/topic/show?id=e3ba99123ec' target=_blank style='color:#2F92EE;'>#静脉成形术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99123, encryptionId=e3ba99123ec, topicName=静脉成形术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=226a143, createdName=cathymary, createdTime=Fri Jul 05 02:32:00 CST 2019, time=2019-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697770, encodeId=423a169e77077, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Tue Apr 23 01:32:00 CST 2019, time=2019-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2004702, encodeId=c52d2004e02be, content=<a href='/topic/show?id=4e8a5400816' target=_blank style='color:#2F92EE;'>#成形术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54008, encryptionId=4e8a5400816, topicName=成形术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fb6449, createdName=ZGMFX24A, createdTime=Mon Dec 17 00:32:00 CST 2018, time=2018-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031925, encodeId=5b0f1031925b0, content=谢谢梅斯提供这么好的信息，学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Mon Oct 01 13:32:00 CST 2018, time=2018-10-01, status=1, ipAttribution=)]
    2018-12-17 ZGMFX24A

    #成形术#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2000596, encodeId=a498200059671, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Jan 23 12:32:00 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819052, encodeId=a41518190527a, content=<a href='/topic/show?id=e3ba99123ec' target=_blank style='color:#2F92EE;'>#静脉成形术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99123, encryptionId=e3ba99123ec, topicName=静脉成形术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=226a143, createdName=cathymary, createdTime=Fri Jul 05 02:32:00 CST 2019, time=2019-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697770, encodeId=423a169e77077, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Tue Apr 23 01:32:00 CST 2019, time=2019-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2004702, encodeId=c52d2004e02be, content=<a href='/topic/show?id=4e8a5400816' target=_blank style='color:#2F92EE;'>#成形术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54008, encryptionId=4e8a5400816, topicName=成形术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7fb6449, createdName=ZGMFX24A, createdTime=Mon Dec 17 00:32:00 CST 2018, time=2018-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031925, encodeId=5b0f1031925b0, content=谢谢梅斯提供这么好的信息，学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Mon Oct 01 13:32:00 CST 2018, time=2018-10-01, status=1, ipAttribution=)]
    2018-10-01 内科新手

    谢谢梅斯提供这么好的信息，学到很多

    0