Int J Oral Max Surg:抗血小板药物会增加拔牙后出血的风险吗?

2017-10-23 MedSci MedSci原创

本研究的目的是评估服用阿司匹林或氯吡格雷的患者拔牙后出血的风险。

本研究的目的是评估服用阿司匹林或氯吡格雷的患者拔牙后出血的风险。

采用交叉研究评估了服用阿司匹林(80 mg /d)或氯吡格雷(75 mg / d)并接受拔牙的患者。在第一阶段,不停服阿司匹林(组1)或氯吡格雷(组2)拔牙。在第二 阶段,患者在拔牙前5天停服抗血小板药物。拔牙后使用视觉模拟量表(VAS)评估72小时后出血。对组1进行血小板功能测定(PFA),对组2进行流式细胞术评估血管扩张剂刺激的磷蛋白(VASP)。研究了38例患者:第1组为20例,第2组为18例。两个阶段组1和组2之间的出血严重程度没有差异(P> 0.05)。两个阶段组1的平均胶原/肾上腺素膜终止时间(PFA)有显着差异(P = 0.001)。两个阶段组2的血小板反应性指数(VASP的流式细胞术)有显着差异(P = 0.001)。根据这个交叉研究,可以不用停服阿司匹林或氯吡格雷,安全地拔牙。

原始出处:

F. Akhlaghi, et al. Do antiplatelet drugs increase the risk of bleeding after tooth extraction? A case-crossover study. International Journal of Oral and Maxillofacial Surgery. 2017 November. doi: 10.1016/j.ijom.2017.06.002

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    2018-05-02 小几洁
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    2017-10-25 xre2013
  5. [GetPortalCommentsPageByObjectIdResponse(id=2032551, encodeId=56c2203255187, content=<a href='/topic/show?id=e00855e5387' target=_blank style='color:#2F92EE;'>#抗血小板药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55753, encryptionId=e00855e5387, topicName=抗血小板药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Mon May 28 04:40:00 CST 2018, time=2018-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1776696, encodeId=dac91e7669686, content=<a href='/topic/show?id=fbf78905420' target=_blank style='color:#2F92EE;'>#血小板药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89054, encryptionId=fbf78905420, topicName=血小板药物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ff838995252, createdName=songbq, createdTime=Sat Apr 21 08:40:00 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2020268, encodeId=c47f202026859, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Wed May 02 17:40:00 CST 2018, time=2018-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574221, encodeId=344115e422119, content=<a href='/topic/show?id=36fc56212c6' target=_blank style='color:#2F92EE;'>#拔牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56212, encryptionId=36fc56212c6, topicName=拔牙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9c5216012416, createdName=xre2013, createdTime=Wed Oct 25 12:40:00 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255584, encodeId=6d68255584ca, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Tue Oct 24 09:50:59 CST 2017, time=2017-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255439, encodeId=073b25543988, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon Oct 23 21:48:43 CST 2017, time=2017-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255436, encodeId=f5c72554366b, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon Oct 23 21:48:06 CST 2017, time=2017-10-23, status=1, ipAttribution=)]
    2017-10-24 明天会更好!

    谢谢分享.学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2032551, encodeId=56c2203255187, content=<a href='/topic/show?id=e00855e5387' target=_blank style='color:#2F92EE;'>#抗血小板药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55753, encryptionId=e00855e5387, topicName=抗血小板药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Mon May 28 04:40:00 CST 2018, time=2018-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1776696, encodeId=dac91e7669686, content=<a href='/topic/show?id=fbf78905420' target=_blank style='color:#2F92EE;'>#血小板药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89054, encryptionId=fbf78905420, topicName=血小板药物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ff838995252, createdName=songbq, createdTime=Sat Apr 21 08:40:00 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2020268, encodeId=c47f202026859, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Wed May 02 17:40:00 CST 2018, time=2018-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574221, encodeId=344115e422119, content=<a href='/topic/show?id=36fc56212c6' target=_blank style='color:#2F92EE;'>#拔牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56212, encryptionId=36fc56212c6, topicName=拔牙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9c5216012416, createdName=xre2013, createdTime=Wed Oct 25 12:40:00 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255584, encodeId=6d68255584ca, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Tue Oct 24 09:50:59 CST 2017, time=2017-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255439, encodeId=073b25543988, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon Oct 23 21:48:43 CST 2017, time=2017-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255436, encodeId=f5c72554366b, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon Oct 23 21:48:06 CST 2017, time=2017-10-23, status=1, ipAttribution=)]
    2017-10-23 1ddf0692m34(暂无匿称)

    学习了.谢谢分享

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2032551, encodeId=56c2203255187, content=<a href='/topic/show?id=e00855e5387' target=_blank style='color:#2F92EE;'>#抗血小板药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55753, encryptionId=e00855e5387, topicName=抗血小板药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Mon May 28 04:40:00 CST 2018, time=2018-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1776696, encodeId=dac91e7669686, content=<a href='/topic/show?id=fbf78905420' target=_blank style='color:#2F92EE;'>#血小板药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89054, encryptionId=fbf78905420, topicName=血小板药物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8ff838995252, createdName=songbq, createdTime=Sat Apr 21 08:40:00 CST 2018, time=2018-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2020268, encodeId=c47f202026859, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Wed May 02 17:40:00 CST 2018, time=2018-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574221, encodeId=344115e422119, content=<a href='/topic/show?id=36fc56212c6' target=_blank style='color:#2F92EE;'>#拔牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56212, encryptionId=36fc56212c6, topicName=拔牙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9c5216012416, createdName=xre2013, createdTime=Wed Oct 25 12:40:00 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255584, encodeId=6d68255584ca, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Tue Oct 24 09:50:59 CST 2017, time=2017-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255439, encodeId=073b25543988, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Mon Oct 23 21:48:43 CST 2017, time=2017-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255436, encodeId=f5c72554366b, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon Oct 23 21:48:06 CST 2017, time=2017-10-23, status=1, ipAttribution=)]
    2017-10-23 天地飞扬

    谢谢分享!

    0

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