JAHA:主动脉狭窄患者的左房容量和死亡率

2017-11-09 xiangting MedSci原创

LA扩大是AS死亡率的一个重要预测因子,补充了已知的结局预测因子。

左心房(LA)扩大在主动脉狭窄(AS)患者中很常见,但其对预后的影响尚不清楚。这项研究探讨了左心房容量(LAV)和根据身材大小标准化的LAV对预测AS死亡率的价值。

纳入了1351例AS患者,诊断时为窦性心律,并分析了随访期内的全因死亡率。测量了LA扩大的5个参数:未标化LAV和标准化的比率LAV(LAV/体表面积[BSA]和LAV/身高)和异速LAV(LAV/BSA1.7和LAV/身高2.0)。对于每个参数,四分位数最高的患者死亡风险较高,而结局与其他四分位数更好或相似。LAV> 95mL和LAV /BSA> 50mL/m2患者的5年生存率低于无或轻度LA患者(P 均<0.001)。调整既定结局预测因子后,包括手术, LAV>95mL(校正风险比,1.40 [95%置信区间,1.06-1.88])和LAV/BSA > 50 mL/m2死亡风险较高(调整风险比1.42 [95%置信区间,1.08-1.91])。LAV/BSA和LAV显示出良好和相似的预测价值,而其他量化方法没有显示更好的结局预测价值。基线重度AS患者,维持(≥50%)射血分数和症状没有或很小,LA扩大与死亡率显著相关(LAV> 95mL校正风险比,1.87 [95%置信区间,1.02-3.44],LAV/BSA>50mL/m 2校正风险比1.90 [95%置信区间,1.03-3.56])。

LA扩大是AS死亡率的一个重要预测因子,补充了已知的结局预测因子。LAV和LAV/ BSA具有相近的预测性能,在临床实践中可用于评估风险分层。

原始出处:
Dan Rusinaru, et al. Left Atrial Volume and Mortality in Patients With Aortic Stenosis. JAHA. 31 October 2017. 

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    2017-11-11 智智灵药
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    2017-11-10 orangesking

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1267594, encodeId=6fcb126e594c2, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sat Nov 11 02:29:00 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1315155, encodeId=201a131515573, content=<a href='/topic/show?id=c115231e9dc' target=_blank style='color:#2F92EE;'>#主动脉狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23179, encryptionId=c115231e9dc, topicName=主动脉狭窄)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2f8f432, createdName=longerg, createdTime=Sat Nov 11 02:29:00 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415222, encodeId=da37141522217, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Sat Nov 11 02:29:00 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1496886, encodeId=5696149688675, content=<a href='/topic/show?id=217b33259df' target=_blank style='color:#2F92EE;'>#动脉狭窄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33259, encryptionId=217b33259df, topicName=动脉狭窄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4ae9287436, createdName=piaojinhua, createdTime=Sat Nov 11 02:29:00 CST 2017, time=2017-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=260380, encodeId=ad7426038070, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Fri Nov 10 23:43:36 CST 2017, time=2017-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259991, encodeId=e0d12599912c, content=不错了.学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Thu Nov 09 12:25:01 CST 2017, time=2017-11-09, status=1, ipAttribution=)]
    2017-11-09 中医痴

    不错了.学习了.谢谢分享!

    0

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