Hypertension:妊娠和哺乳期间母体膳食对盐诱导高血压和肾损伤影响显著

2014-12-09 高晓方 译 医学论坛网

美国一项研究表明,在成年SS大鼠中,妊娠和哺乳期间母体膳食对盐诱导高血压和肾损伤具有显著影响。论文12月1日在线发表于《高血压》(Hypertension)杂志。 与基于酪蛋白AIN-76A膳食喂养的SS/Mcw大鼠相比,在基于谷类5L2F膳食喂养的SS/Crl大鼠中由高盐膳食诱导的高血压和肾损伤显著减轻,并且可维持多代。此项研究将来自于SS/Mcw或SS/Crl种群的单细胞胚胎移植至其

美国一项研究表明,在成年SS大鼠中,妊娠和哺乳期间母体膳食盐诱导高血压肾损伤具有显著影响。论文12月1日在线发表于《高血压》(Hypertension)杂志。

与基于酪蛋白AIN-76A膳食喂养的SS/Mcw大鼠相比,在基于谷类5L2F膳食喂养的SS/Crl大鼠中由高盐膳食诱导的高血压和肾损伤显著减轻,并且可维持多代。此项研究将来自于SS/Mcw或SS/Crl种群的单细胞胚胎移植至其他种群的代母,并对后者维持原有膳食。断奶后所有后代均接受AIN-76A膳食。

结果显示,在SS/Crl胚胎移植至SS/Mcw代母所产大鼠中,盐诱导高血压和肾损伤均显著加重。与之相反,在SS/Mcw胚胎移植至SS/Crl代母所产大鼠中,盐诱导高血压和肾损伤均显著减轻。

原始出处:

Geurts AM1, Mattson DL2, Liu P2, Cabacungan E2, Skelton MM2, Kurth TM2, Yang C2, Endres BT2, Klotz J2, Liang M2, Cowley AW Jr2.Maternal Diet During Gestation and Lactation Modifies the Severity of Salt-Induced Hypertension and Renal Injury in Dahl Salt-Sensitive Rats.Hypertension. 2014 Dec 1. pii: HYPERTENSIONAHA.114.04179. [Epub ahead of print]


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    2015-05-08 feather89
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    2014-12-11 zhaojie88
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