Neurology:丘脑神经网络枢纽度对癫痫患者预后影响

2017-05-21 zhangfan MedSci原创

丘脑神经网络与癫痫复发相关,丘脑神经网络枢纽度可作为患者预后的潜在预测手段

近日研究人员利用静息态fMRI对颞叶性癫痫(TLE)患者进行手术前的脑功能结构的表征以确定脑功能结构对患者预后的影响。

研究招募了56名单侧颞叶癫痫患者进行手术其中35人术后1年无癫痫症状而21人仍会发病,同时招募了28名对照志愿者。研究人员对所有参与者进行术前静息态连接功能和大脑神经网络(节点和整体)的特性评估。

研究发现,相比于术后无症状和健康人群,术后症状未缓解的患者显示在同侧和对侧丘脑特定节点枢纽度增加,表现为对侧半球区域分布的连接数的增加。模拟丘脑切除术可降低术后未缓解患者的网络集成。模型预测显示该方法对颞叶性癫痫术后效果的预测精度为76%,现有的临床手段的预测精度仅为58%。

研究认为,丘脑神经网络与癫痫复发相关,丘脑神经网络枢纽度可作为患者预后的潜在预测手段。

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    2018-01-16 siiner
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beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20878, encryptionId=c8a7208e8a8, topicName=丘脑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fb8814960000, createdName=xlwang2696, createdTime=Tue May 23 00:14:00 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630347, encodeId=0fb4163034e40, content=<a href='/topic/show?id=44e0e449217' target=_blank style='color:#2F92EE;'>#神经网络#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74492, encryptionId=44e0e449217, topicName=神经网络)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6ff21497204, createdName=by2016, createdTime=Tue May 23 00:14:00 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201083, encodeId=6baa2010831e, content=学习了,提高了认识, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/39b6a0099eb602e8ac1f7e10d5d440a9.jpg, createdBy=dee01724555, createdName=杨利洪, createdTime=Mon May 22 07:13:30 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200868, encodeId=fd5e20086885, content=给干干脆脆, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEKXpC8j9TaoCpG4yIB3skibUZ0ricmVQ6KKIVpqYQxINrmlibsPZSia7GOUupzuINf8UITMib8awsjjkPw/0, createdBy=abbf1713451, createdName=zt123, createdTime=Sun May 21 12:52:20 CST 2017, time=2017-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200837, encodeId=80ff20083e6c, content=很不错,学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Sun May 21 11:29:32 CST 2017, time=2017-05-21, status=1, ipAttribution=)]
    2018-01-02 yinhl1978
  5. [GetPortalCommentsPageByObjectIdResponse(id=1709605, encodeId=41591e0960509, content=<a href='/topic/show?id=a919849e3ff' target=_blank style='color:#2F92EE;'>#脑神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84973, encryptionId=a919849e3ff, topicName=脑神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b8031759349, createdName=siiner, createdTime=Tue Jan 16 16:14:00 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1691898, encodeId=c35f1691898e3, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20878, encryptionId=c8a7208e8a8, topicName=丘脑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fb8814960000, createdName=xlwang2696, createdTime=Tue May 23 00:14:00 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630347, encodeId=0fb4163034e40, content=<a href='/topic/show?id=44e0e449217' target=_blank style='color:#2F92EE;'>#神经网络#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74492, encryptionId=44e0e449217, topicName=神经网络)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6ff21497204, createdName=by2016, createdTime=Tue May 23 00:14:00 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201083, 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GetPortalCommentsPageByObjectIdResponse(id=200837, encodeId=80ff20083e6c, content=很不错,学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Sun May 21 11:29:32 CST 2017, time=2017-05-21, status=1, ipAttribution=)]
    2017-05-23 xlwang2696
  6. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20878, encryptionId=c8a7208e8a8, topicName=丘脑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fb8814960000, createdName=xlwang2696, createdTime=Tue May 23 00:14:00 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630347, encodeId=0fb4163034e40, content=<a href='/topic/show?id=44e0e449217' target=_blank style='color:#2F92EE;'>#神经网络#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74492, encryptionId=44e0e449217, topicName=神经网络)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6ff21497204, createdName=by2016, createdTime=Tue May 23 00:14:00 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201083, 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GetPortalCommentsPageByObjectIdResponse(id=200837, encodeId=80ff20083e6c, content=很不错,学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Sun May 21 11:29:32 CST 2017, time=2017-05-21, status=1, ipAttribution=)]
    2017-05-23 xlwang2696
  7. 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GetPortalCommentsPageByObjectIdResponse(id=200837, encodeId=80ff20083e6c, content=很不错,学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Sun May 21 11:29:32 CST 2017, time=2017-05-21, status=1, ipAttribution=)]
  8. 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GetPortalCommentsPageByObjectIdResponse(id=200837, encodeId=80ff20083e6c, content=很不错,学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Sun May 21 11:29:32 CST 2017, time=2017-05-21, status=1, ipAttribution=)]
    2017-05-22 杨利洪

    学习了,提高了认识

    0

  9. 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GetPortalCommentsPageByObjectIdResponse(id=200837, encodeId=80ff20083e6c, content=很不错,学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Sun May 21 11:29:32 CST 2017, time=2017-05-21, status=1, ipAttribution=)]
    2017-05-21 zt123

    给干干脆脆

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=200837, encodeId=80ff20083e6c, content=很不错,学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Sun May 21 11:29:32 CST 2017, time=2017-05-21, status=1, ipAttribution=)]
    2017-05-21 中医痴

    很不错,学习了!谢谢分享!

    0

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