BMC Cancer：IIIB/IV期非小细胞肺癌一线化疗方案用不用伊立替康？

2015-12-21 MedSci译 MedSci原创

研究者比较了IIIB/IV期非小细胞肺癌(NSCLC)患者一线治疗：基于伊立替康的化疗 (IBC) vs.非伊立替康的化疗(NIBC)，这两种治疗的有效性和毒性。通过检索相关数据库，获取比较IBC和NIBC的相关文章，采集整体生存期（OS）和无进展生存期 (PFS) 等数据进行荟萃分析得出风险比（HRs）；使用整体反应率 (ORR) 和毒性频率等数据进行荟萃分析得出相对风险率（RR）。荟萃分析共纳

研究者比较了IIIB/IV期非小细胞肺癌(NSCLC)患者一线治疗：基于伊立替康的化疗 (IBC) vs.非伊立替康的化疗(NIBC)，这两种治疗的有效性和毒性。

通过检索相关数据库，获取比较IBC和NIBC的相关文章，采集整体生存期（OS）和无进展生存期 (PFS) 等数据进行荟萃分析得出风险比（HRs）；使用整体反应率 (ORR) 和毒性频率等数据进行荟萃分析得出相对风险率（RR）。

荟萃分析共纳入了7篇随机对照试验，其中6篇为亚洲人群。共涉及1473名先前未经治疗的IIIB/IV期NSCLC患者。荟萃分析数据显示，IBC和NIBC组ORR相似(RR: 1.08, 95 %CI: 0.94 to 1.23, p = 0.30)，OS相似(HR: 0.97, 95 %CI: 0.88 to 1.07, p = 0.56)，PFS相似(HR: 1.02, 95 %CI: 0.97 to 1.08, p = 0.38)。但是亚洲人与非亚洲人的比较发现OS存在差异(HR: 0.94 vs 1.87, p = 0.007)。IBC组与NIBC组相比，血液系统毒性反应差异不大(RR: 0.79, 95 %CI: 0.60 to 1.04, p = 0.09)，但非血液系统毒性反应却更糟糕(RR: 2.28, 95 %CI: 1.60 to3.24, p < 0.001)。

对现有研究进行了荟萃分析表明，对IIIB/IV期NSCLC患者，IBC或NIBC治疗具有相似的ORR、PFS、OS。对于亚洲人，研究者推荐IBC作为该类患者的一线治疗方案，不过该方案的非血液系统毒性需得到重视。

原始出处：

Yang XQ, Li CY,et al.Comparison of first-line chemotherapy based on irinotecan or other drugs to treat non-small cell lung cancer in stage IIIB/IV: a systematic review and meta-analysis.BMC Cancer. 2015 Dec 16;15(1):949.

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2016-06-05 okhuali

#一线化疗#

35 0
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2016-11-15 lingaifan

#非小细胞#

0 0
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2016-09-22 ms3025846204744509

#BMC#

25 0
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2016-07-01 juliusluan78

#III#

29 0
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2016-01-13 Lynee劲飞扬

细节

98 0
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2016-01-04 xyfg98

好的

130 0
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2015-12-27 wzf990214

赞一个

106 0
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2015-12-27 wzf990214

值得学习借鉴

122 0
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2015-12-26 hixiaoluo

值得收藏，学习，谢谢分享

100 0

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