Hepatolog:肥胖和非酒精性脂肪性肝炎相关肝移植患者数量将增加

2017-08-29 MedSci MedSci原创

鉴于人群中肥胖流行趋势,预计因NASH相关肝硬化导致的肝移植将显著增加。需要持续的努力以遏制肥胖的流行,以减少未来NASH相关负担。

在美国,需要做肝移植的肝脏疾病中,非酒精性脂肪性肝炎(non-alcoholic steatohepatitis,NASH)相关肝硬化呈现最快增长趋势。研究的目的是确定因肥胖和NASH相关肝硬化增加,额外需要进行肝移植的患者数目。为未来NASH对肝移植造成的负担,做出预测。

研究者使用2000-2014年间器官采购和移植网络数据库中的数据,以获得NASH相关肝移植患者的数量。根据美国人口普查局(US Census Bureau)和国家健康与营养调查局(National Health and Nutrition Examination Survey)的数据,估计2000年至2014年间肥胖人口数量。根据肥胖流行趋势,在肥胖患病率和NASH相关肝移植患者之间建立时间差。研究者利用美国人口普查局对2016-2030年人口进行预测的数据,预测肥胖、NASH相关肝移植增加的数量。从2000-2014年,人口肥胖率增加了44.9%,NASH相关肝移植患者的数量从391例增加到1605例。肥胖流行率的增加与9年后衍生和验证组中增加的NASH相关肝移植有很大关联。根据这些数据,在2016年至2030年期间,每年NASH相关肝移植患者将增加55.4%。肥胖比率有显著的地域差异,预期将在NASH相关肝移植患者中显著增加(p<0.01)。

鉴于人群中肥胖流行趋势,预计因NASH相关肝硬化导致的肝移植将显著增加。需要持续的努力以遏制肥胖的流行,以减少未来NASH相关负担。

原始出处:

Parikh ND, Marrero WJ, Wang J, et al. Projected increase in obesity and non-alcoholic steatohepatitis-related liver transplantation waitlist additions in the United States. Hepatology, 2017, Aug 17. doi: 10.1002/hep.29473.

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    2017-10-01 qjddjq
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    2017-08-31 gwc384
  6. [GetPortalCommentsPageByObjectIdResponse(id=1676348, encodeId=987d16e63489b, content=<a href='/topic/show?id=397299e19c7' target=_blank style='color:#2F92EE;'>#非酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99719, encryptionId=397299e19c7, topicName=非酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d18c27357544, createdName=Tommy1958, createdTime=Sat Jul 21 00:24:00 CST 2018, time=2018-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1673326, encodeId=c9a816e332672, content=<a href='/topic/show?id=757b954e922' target=_blank style='color:#2F92EE;'>#酒精性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95479, encryptionId=757b954e922, topicName=酒精性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=398f26933958, createdName=huiwelcome, createdTime=Fri Feb 02 00:24:00 CST 2018, time=2018-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956029, encodeId=19a41956029c4, content=<a href='/topic/show?id=8a048435058' target=_blank style='color:#2F92EE;'>#脂肪性肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84350, encryptionId=8a048435058, topicName=脂肪性肝炎)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Jr8S1dfvNyP22t32IFDXJXnpd5AGlDibiajL5cl3pxj7OPCeAeibLhzOmZn5Q2Oicc6uKOCnxGNOggdLtI3hIW7huQ/132, createdBy=66e52500008, createdName=Tamikia, createdTime=Fri Sep 08 19:24:00 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810043, encodeId=7ce1181004323, content=<a href='/topic/show?id=70f484349b5' target=_blank style='color:#2F92EE;'>#脂肪性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84349, encryptionId=70f484349b5, topicName=脂肪性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Sun Oct 01 04:24:00 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426811, encodeId=50081426811c1, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Thu Aug 31 13:24:00 CST 2017, time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238626, encodeId=a9ce238626d0, content=文章很好.值得分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Wed Aug 30 10:24:05 CST 2017, time=2017-08-30, status=1, ipAttribution=)]
    2017-08-30 1e10c84am36(暂无匿称)

    文章很好.值得分享

    0

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