Int J Cancer:膳食炎症指标与癌症预后显著相关(Meta分析)

2017-08-31 MedSci MedSci原创

慢性炎症在癌症的发生发展中起到了促进作用。某些饮食种类及生活习惯等可干预因素对炎-癌转化有重要影响。日常饮食中的各类食物可按照一定的标准分为促炎症食物和抗炎症食物,通过促进或抑制体内的炎症微环境影响某些癌症的发生和发展。由不良饮食和体力活动缺乏导致的肥胖本身即可营造炎症环境,与营养因素共同推动癌症的发生发展进程。另外,既往的研究发现,促炎症饮食模式与癌症风险和死亡率增加有关。来自美国的研究人员对当

慢性炎症在癌症的发生发展中起到了促进作用。某些饮食种类及生活习惯等可干预因素对炎-癌转化有重要影响。日常饮食中的各类食物可按照一定的标准分为促炎症食物和抗炎症食物,通过促进或抑制体内的炎症微环境影响某些癌症的发生和发展。由不良饮食和体力活动缺乏导致的肥胖本身即可营造炎症环境,与营养因素共同推动癌症的发生发展进程。另外,既往的研究发现,促炎症饮食模式与癌症风险和死亡率增加有关。

来自美国的研究人员对当前已发表的关于饮食的炎症指标分析(DII)评分和与之相关的癌症风险和死亡率的文献进行了一个系统的回顾和Meta分析。

研究人员回顾了1980-2016年11月间的相关文献,这些文章均来自在线数据库(PubMed和EMBASE、Scopus)的检测,主题是DII和各种癌症的风险、发生率和死亡率之间的关系。研究人员总结了符合纳入标准的研究的结果,并使用STATA进行Meta分析。

研究人员共检索到了63篇已发表的文章,然后根据标题、摘要和全文回顾之后,确定了24项研究符合纳入标准。所有的研究都通过具体的食物频率问卷,计算出了DII评分。

纳入的24项研究中,13项为病例对照研究,6项为前瞻性队列研究,1项为回顾性队列研究,3项为随机对照试验,1项未指定研究设计形式。研究中,最常见的癌症是结直肠癌乳腺癌肺癌和前列腺癌。DII累积评分,最高组比最低组的整体癌症发病率的风险增加了25%(RR 1.25,95% CI:1.16-1.35),患上癌症的几率高了75%(RR:1.75,95%CI:1.43-2.16),且癌症死亡率的风险增加了67%(RR 1.67,95% CI:1.13-2.48)。基于癌症类型的分层研究中,依然存在该正相关性(乳腺癌中的RR:1.12,95% CI:1.03-1.22;结直肠癌中的RR:1.33,95%CI:1.22-1.46;肺癌中的RR:1.30,95%CI:1.13-1.50)。

无论癌症类型、研究人群和研究设计方法的不同,DII评分较高与癌症的发生和死亡之间都存在着一致且显著的正相关性。

原始出处:

Fowler ME, Akinyemiju TF,et al.Meta-analysis of the association between dietary inflammatory index (DII) and cancer outcomes.Int J Cancer. 2017 Aug 10. doi: 10.1002/ijc.30922. [Epub ahead of print]

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    2018-03-06 一闲
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    2018-08-08 guojianrong
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    2017-11-27 1771ae4158m

    学习一下很不错

    0

  4. 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Wed Sep 13 22:57:47 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243004, encodeId=22ef24300460, content=不错的.学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Sep 11 23:13:25 CST 2017, time=2017-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239527, encodeId=9a2b23952e8e, content=促炎症饮食模式与癌症风险和死亡率增加有关., beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Sat Sep 02 00:36:32 CST 2017, time=2017-09-02, status=1, ipAttribution=)]
    2017-10-31 1771ae4158m

    学习一下很不错

    0

  5. 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likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Sat Sep 02 00:36:32 CST 2017, time=2017-09-02, status=1, ipAttribution=)]
    2017-10-23 1771ae4158m

    学习一下很不错

    0

  6. 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Wed Sep 13 22:57:47 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243004, encodeId=22ef24300460, content=不错的.学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Sep 11 23:13:25 CST 2017, time=2017-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239527, encodeId=9a2b23952e8e, content=促炎症饮食模式与癌症风险和死亡率增加有关., beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Sat Sep 02 00:36:32 CST 2017, time=2017-09-02, status=1, ipAttribution=)]
    2017-10-20 1771ae4158m

    学习一下很不错

    0

  7. 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    2017-09-27 1771ae4158m

    学习一下很不错

    0

  8. 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Wed Sep 13 22:57:47 CST 2017, time=2017-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=243004, encodeId=22ef24300460, content=不错的.学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Sep 11 23:13:25 CST 2017, time=2017-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=239527, encodeId=9a2b23952e8e, content=促炎症饮食模式与癌症风险和死亡率增加有关., beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Sat Sep 02 00:36:32 CST 2017, time=2017-09-02, status=1, ipAttribution=)]
    2017-09-13 虈亣靌

    谢谢分享谢谢分享

    0

  9. 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likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Sat Sep 02 00:36:32 CST 2017, time=2017-09-02, status=1, ipAttribution=)]
    2017-09-11 虈亣靌

    不错的.学习了!谢谢分享!

    0

  10. 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    2017-09-02 随梦飞扬

    促炎症饮食模式与癌症风险和死亡率增加有关.

    0

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我们对红肉的欲望似乎永不满足,这对健康和地球都不好。不过,具有可持续性的“代肉”正跃跃欲试,不过真的有人愿意尝试这种新型“肉食”吗?

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免疫功能不全时,大多数由病毒引起的癌症会增加,但一些没有建立病毒病因学形式的癌症也有所增加,尤其是非黑色素瘤皮肤癌(non-melanoma skin carcinoma,NMSC)。来自瑞典的研究人员随访了13429例接受过实体器官移植的瑞典患者在移植后,癌症的发生情况。研究人员得到了他们的肿瘤标本,并对前89个标本进行了基因测序(62例非黑色素瘤皮肤癌,27例其他癌症)。使用两种生物信息学算法

Int J Cancer:糖尿病、使用他汀类药物和二甲双胍对癌症患者的死亡率的影响有哪些?

糖尿病(DM)和癌症都是常见病,他们多发于同一患者。既往的研究已经发现DM能影响癌症患者的死亡率,但是对糖尿病的治疗与癌症全因死亡率及死因特异性死亡率之间相关性仍明确阐明。来自芬兰的研究人员调查了与糖尿病、他汀类药物的使用和二甲双胍的使用相关的全因死亡率和死因特异性死亡率的动态。研究对象包括来自芬兰的39900例癌症患者,其中在随访开始时,有19822例患者没有糖尿病,有20078例患者患有糖尿病

Oncotarget:研究人员开发出修饰菌株,提高沙门氏菌介导的肿瘤治疗安全性

癌症对于患者来说往往非常沉重,并且对患者及其家庭造成巨大经济负担,研究人员一直在致力于寻找治疗方法和手段。微生物的应用是一种由来已久的治疗策略,研究人员也一直在研究应用中如何增加针对性和改善致病性。

Int J Cancer:癌症后怀孕的妊娠结局大多令人欣慰,但这些癌症仍需密切监测

2015年欧洲癌症大会(ECC)上发布的一则研究结果表明,对于那些早期暴露于癌症及癌症相关影像学检查及治疗的胎儿来说,其18-36周的生长发育情况似乎跟正常情况的胎儿无异。该项研究发表在2015年9月《新英格兰医学杂志》(NEJM)上。研究显示化疗对产后婴儿的生长发育、认知或心脏功能还没有明确的影响。但该研究只纳入了129例来自比利时、荷兰、意大利和捷克共和国的儿童作为观察组(产前暴露组),而另设