Ann Rheum Dis:颈动脉超声可用于评估类风湿关节炎患者心血管风险

2014-03-20 xc19851030 dxy

类风湿关节炎(RA)可促使动脉硬化加速发生,增加了患者因心血管(CV)事件而导致的死亡率。为研究颈动脉超声检查(US)是否有助于对RA患者进行CV风险分层,来自西班牙桑坦德Marqués de Valdecilla大学医院的Corrales博士等人进行了一项研究。研究发表于2014年3月的Ann Rheum Dis杂志上。研究发现,颈动脉超声可用于评估RA患者心血管风险。研究纳入了370例无CV事

类风湿关节炎(RA)可促使动脉硬化加速发生,增加了患者因心血管(CV)事件而导致的死亡率。为研究颈动脉超声检查(US)是否有助于对RA患者进行CV风险分层,来自西班牙桑坦德Marqués de Valdecilla大学医院的Corrales博士等人进行了一项研究。研究发表于2014年3月的Ann Rheum Dis杂志上。研究发现,颈动脉超声可用于评估RA患者心血管风险。


研究纳入了370例无CV事件史的RA患者,使用超声测量患者颈动脉内-中膜厚度(cIMT)并检查是否存在斑块。EUALR系统性冠状动脉风险(SCORE)评分及修正SCORE(mSCORE)评分对CV风险分层如下:低风险(<1%)、中风险(≥1%并<5%),高风险(≥5%并<10%),极高风险(≥10%)。根据mSCORE评分,凡以下3条特别标准满足2条以上者,其CV风险评分应乘1.5:(1)病程超过10年;(2)类风湿因子(RF)或抗环瓜氨酸抗体(抗CCP)阳性;(3)出现关节外症状。

纳入患者的平均病程为9.8年,其中250例(68%)患者存在RF或抗CCP抗体阳性,61例(17%)存在关节外症状。43例患者因合并2型糖尿病或严重的慢性肾脏病而被排除研究。剩余的327例RA患者根据mSCORE评分进行CV风险分层,结果如下:96例患者(29.3%)为低风险,201例患者(61.5%)为中风险,30例患者(9.2%)为高/极高风险。

与SCORE评分相比,5例患者通过mSCORE评分从中风险上升为高/极高风险。严重的颈动脉US异常(cIMT>0.9mm和/或存在斑块)在mSCORE评分为低风险的患者组中较少见(13%)。然而,在mSCORE评分为中风险的患者组中,严重的颈动脉US异常在63%的患者中被确认。mSCORE评分高风险(≥5%)、mSCORE评分中风险(≥1%并<5%)合并颈动脉US严重异常,对高/极高CV风险的高度敏感。

该研究结果提示,颈动脉US可用于RA患者的CV风险评估。

原始来源:
Corrales A1, González-Juanatey C, Peiró ME, Blanco R, Llorca J, González-Gay MA.Carotid ultrasound is useful for the cardiovascular risk stratification of patients with rheumatoid arthritis: results of a population-based study.Ann Rheum Dis. 2014 Apr 1;73(4):722-7. doi: 10.1136/annrheumdis-2012-203101. Epub 2013 Mar 16.

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    2014-03-22 lmm397
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