Gastroenterology:健康肠道菌群有助预防代谢综合征

2014-11-27 佚名 生物谷

根据佐治亚州立大学和康奈尔大学研究人员证实:居住在肠道内的有助健康的肠道菌群,可以帮助治疗或预防代谢综合征。他们的研究结果发表在Gastroenterology杂志上。 他们证实,肠上皮细胞缺乏Toll样受体5,肠道菌群组合发生改变,而这会促进低度炎症和代谢综合征,变化后的细菌种群更具侵略性,会产生鞭毛蛋白和脂多糖等物质,进一步促进炎症。 在美国,代谢综合征影响34%的




根据佐治亚州立大学和康奈尔大学研究人员证实:居住在肠道内的有助健康的肠道菌群,可以帮助治疗或预防代谢综合征。他们的研究结果发表在Gastroenterology杂志上。[pdf free]

他们证实,肠上皮细胞缺乏Toll样受体5,肠道菌群组合发生改变,而这会促进低度炎症和代谢综合征,变化后的细菌种群更具侵略性,会产生鞭毛蛋白和脂多糖等物质,进一步促进炎症。

在美国,代谢综合征影响34%的成年人。当一个人有这样的危险因素时:一个大腰围,高甘油三酯水平,低HDL胆固醇水平,高血压和高空腹血糖,会被诊断为患有代谢综合征。

一旦患上代谢综合征,发生心脏疾病和糖尿病的风险也增加。由于代谢综合征正变得越来越普遍,科学家们正在探索其中可能的原因。在先前发表在Science杂志上的研究中,Gewirtz和其他研究人员发现肠道菌群的改变对引发代谢综合征有促进作用。

肠道菌群在健康中发挥关键功能,当它变得失调,它会促进慢性炎症性疾病,如克罗恩病和溃疡性结肠炎。此外,肠道菌群改变会促进炎症,导致代谢综合征。

原始出处:

Chassaing B1, Ley RE2, Gewirtz AT3.Intestinal Epithelial Cell Toll-like Receptor 5 Regulates the Intestinal Microbiota to Prevent Low-Grade Inflammation and Metabolic Syndrome in Mice.Gastroenterology. 2014 Aug 27. pii: S0016-5085(14)01072-5. doi: 10.1053/j.gastro.2014.08.033. [pdf free]

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    2015-10-30 许安
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    2014-12-01 SSRIs

    现在国内抗生素滥用

    0

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