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Indole Alleviates Diet-Induced Hepatic Steatosis and Inflammation in a Manner Involving Myeloid Cell 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3

期刊: HEPATOLOGY, 2020; 72 (4)

Background and Aims Indole is a microbiota metabolite that exerts anti-inflammatory responses. However, the relevance of indole to human non-alcoholic......

TMPRSS4 Drives Angiogenesis in Hepatocellular Carcinoma by Promoting HB-EGF Expression and Proteolytic Cleavage

期刊: HEPATOLOGY, 2020; 72 (3)

Background and Aims Heparin-binding epidermal growth factor (HB-EGF), a member of the epidermal growth factor family, plays a pivotal role in the prog......

Deficiency in Embryonic Stem Cell Marker Reduced Expression 1 Activates Mitogen-Activated Protein Kinase Kinase 6-Dependent p38 Mitogen-Activated Protein Kinase Signaling to Drive Hepatocarcinogenesis

期刊: HEPATOLOGY, 2020; 72 (1)

Background and Aims Embryonic stem-cell-related transcription factors are central to the establishment and maintenance of stemness and pluripotency, a......

Cilofexor, a NonsteroidalFXRAgonist, in Patients With Noncirrhotic NASH: A Phase 2 Randomized Controlled Trial

期刊: HEPATOLOGY, 2020; 72 (1)

Background and Aims We evaluated the safety and efficacy of cilofexor (formerly GS-9674), a small-molecule nonsteroidal agonist of farnesoid X recepto......

Moesin, an Ezrin/Radixin/Moesin Family Member, Regulates Hepatic Fibrosis

期刊: HEPATOLOGY, 2020; 72 (3)

Background and Aims Moesin, an ezrin/radixin/moesin family member, is involved in the regulation of cell adhesion, polarity, and migration by cross-li......

Model for End-Stage Liver Disease With Additional Criteria to Predict Short-Term Mortality in Severe Flares of Chronic Hepatitis B

期刊: HEPATOLOGY, 2020; 72 (3)

Background and Aims The prognosis in severe acute flares of chronic hepatitis B (AFOCHB) is often unclear. The current study aimed to establish the pr......

Cenicriviroc Treatment for Adults With Nonalcoholic Steatohepatitis and Fibrosis: Final Analysis of the Phase 2b CENTAUR Study

期刊: HEPATOLOGY, 2020; 72 (3)

Background and Aims Cenicriviroc (CVC) is a C-C chemokine receptors type 2 and 5 dual antagonist under evaluation for treating liver fibrosis in adult......

Lysyl Oxidase (LOX) Family Members: Rationale and Their Potential as Therapeutic Targets for Liver Fibrosis

期刊: HEPATOLOGY, 2020; 72 (2)

The cross-linking of structural extracellular matrix (ECM) components, especially fibrillar collagens and elastin, is strongly implicated in fibrosis ......

Longitudinal Association Between Markers of Liver Injury and Mortality in COVID-19 in China

期刊: HEPATOLOGY, 2020; 72 (2)

Background and Aims Coronavirus disease 2019 (COVID-19) is a new infectious disease. To reveal the hepatic injury related to this disease and its clin......

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