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Engineering Tissues and Organs: The Road to the Clinic

期刊: CELL, 2020; 181 (1)

With recent advances in both gene editing and stem cell biology, the promise of cellular therapies is now closer than ever. Clinical trials for the ap......

A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies

期刊: CELL, 2020; 181 (2)

Plants are foundational for global ecological and economic systems, but most plant proteins remain uncharacterized. Protein interaction networks often......

Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer

期刊: CELL, 2020; 181 (2)

Single-cell RNA sequencing (scRNA-seq) is a powerful tool for defining cellular diversity in tumors, but its application toward dissecting mechanisms ......

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

期刊: CELL, 2020; 181 (2)

KRAS mutant pancreatic ductal adenocarcinoma (PDAC) is characterized by a desmoplastic response that promotes hypovascularity, immunosuppression, and ......

Functionally Distinct Neuronal Ensembles within the Memory Engram

期刊: CELL, 2020; 181 (2)

Memories are believed to be encoded by sparse ensembles of neurons in the brain. However, it remains unclear whether there is functional heterogeneity......

Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk

期刊: CELL, 2020; 181 (2)

During human evolution, the knee adapted to the biomechanical demands of bipedalism by altering chondrocyte developmental programs. This adaptive proc......

A Genomic Perspective on the Origin and Emergence of SARS-CoV-2

期刊: CELL, 2020; 181 (2)

The ongoing pandemic of a new human coronavirus, SARS-CoV-2, has generated enormous global concern. We and others in China were involved in the initia......

A Translocation Pathway for Vesicle-Mediated Unconventional Protein Secretion

期刊: CELL, 2020; 181 (3)

Many cytosolic proteins lacking a signal peptide, called leaderless cargoes, are secreted through unconventional secretion. Vesicle trafficking is a m......

Distinct Processing of lncRNAs Contributes to Non-conserved Functions in Stem Cells

期刊: CELL, 2020; 181 (3)

Long noncoding RNAs (lncRNAs) evolve more rapidly than mRNAs. Whether conserved lncRNAs undergo conserved processing, localization, and function remai......

Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice

期刊: CELL, 2020; 181 (3)

Conversion of glial cells into functional neurons represents a potential therapeutic approach for replenishing neuronal loss associated with neurodege......

Early Fate Defines Microglia and Non-parenchymal Brain Macrophage Development

期刊: CELL, 2020; 181 (3)

Central nervous system (CNS) macrophages comprise microglia and border-associated macrophages (BAMs) residing in the meninges, the choroid plexus, and......

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

期刊: CELL, 2020; 181 (4)

The recent emergence of a novel coronavirus (SARS-CoV-2) in China has caused significant public health concerns. Recently, ACE2 was reported as an ent......

Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis

期刊: CELL, 2020; 181 (4)

Chronic obstructive pulmonary disease (COPD) is a progressive condition of chronic bronchitis, small airway obstruction, and emphysema that represents......

Genomic Epidemiology of SARS-CoV-2 in Guangdong Province, China

期刊: CELL, 2020; 181 (5)

Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2 infection and was first reported in central China in December 2019. Extensive molecular su......

Plant Immunity: Danger Perception and Signaling

期刊: CELL, 2020; 181 (5)

Plants employ numerous cell-surface and intracellular immune receptors to perceive a variety of immunogenic signals associated with pathogen infection......

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