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Electrochemical Oxidative C-H Cyanation of Quinoxalin-2(1H)-ones with TMSCN

期刊: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2021; 2021 (15)

Both quinoxalin-2(1H)-ones and nitriles are valuable organic compounds, and it is an interesting task to introduce cyano into quinoxalin-2(1H)-ones. H......

Titanium Tetrachloride-Mediated Approach to Access 2-Chloro-2-Substituted Isoindolin-1-ones through the Addition of Alkynes to Acyliminium ions

期刊: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2021; 2021 (18)

An asymmetric approach to access 2-substituted isoindolin-1-ones 9-11 was developed through TiCl4-mediated addition-chlorination of N,O-acetals 7 a-7 ......

Nickel-Catalyzed Asymmetric Hydrogenation of Hydrazones

期刊: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2021; 2021 (23)

An efficient nickel-catalyzed asymmetric hydrogenation of hydrazones to chiral hydrazines has been realized with up to 99 % yield and 99.4 : 0.6 er. D......

The Development of Organocatalytic Asymmetric Reduction of Carbonyls and Imines Using Silicon Hydrides

期刊: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2021; 2021 (21)

The asymmetric reduction of prochiral ketones and ketimines represents one of the most important and practical chemical transformations toward the syn......

Transition-Metal-Free DMAP-Mediated Aromatic Esterification of Amides with Organoboronic Acids

期刊: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2021; 2021 (22)

A new, transition-metal-free, effective method for aromatic esterification of amides with organoboronic acids has been developed. A wide range of benz......

Regioselective Carbon-Halogen Bond Formation in the Reaction of Ag(III) N-Confused Porphyrin Complex with HCl or HBr

期刊: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2021; 2021 (31)

A facile inner halogenation of Ag(III) NCP complex 1 is reported. Treatment of 1 with 2N HCl and 1N HBr gave 2 and 4, respectively. A demetallized pro......

Sustainable Cascades to Difluoroalkylated Polycyclic Imidazoles

期刊: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2021; 2021 (31)

We reported herein a visible light promoted difluoroalkylated cascade of imidazoles and alkenes to afford highly functionalized polycyclic imidazoles.......

Chemical Synthesis of the Nucleoside Antibiotic Capuramycin

期刊: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2021; 2021 (26)

Capuramycin is an important lead nucleoside antibiotic for the development of new therapeutic agents against the multidrug-resistant Mycobacterium tub......

Asymmetric Synthesis of N-Fmoc-(S)-7-aza-tryptophan via Alkylation of Chiral Nucleophilic Glycine Equivalent

期刊: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2021; 2021 (21)

Ni(II)-complexes, derived from glycine Schiff bases with chiral tridentate ligands, have been used as powerful tools for the synthesis of structurally......

Ring Expansion to 8-Membered Silacycles through Formal Cross-Dimerization of 5-Membered Palladacycles with Silacyclobutanes

期刊: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2021; 2021 (21)

Investigations of the sila-8-membered ring fused biaryls are of high significance for the discovery of new drug lead compounds. However, such compound......

Iron-Catalyzed Synthesis of Pyrrole Derivatives and Related Five-Membered Azacycles

期刊: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2021; 2021 (27)

Pyrrole derivatives and their related five-membered azacycles are a class of important five-membered aromatic nitrogen heterocyclic compounds, and the......

Copper-Catalyzed Direct Oxidative alpha-Alkoxylation of 4-Isochromanones

期刊: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2021; 2021 (17)

The direct oxidative alpha-alkoxylation of carbonyl compounds is very important, highly desirable but relatively rare. A general and convenient approa......

In Situ Preparation of Palladium Nanoparticles for C-2 Selective Arylation of Indoles in Agro-Waste Extract Based Mixed Solvents

期刊: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2021; 2021 (17)

An efficient and practical method for the in situ generation of palladium nanoparticles was successfully established in a water extract of pomelo peel......

A Mild Glycosylation Protocol with Glycosyl 1-Methylimidazole-2-carboxylates as Donors

期刊: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2021; 2021 (30)

A mild glycosylation protocol is developed by using glycosyl 1-methylimidazole-2-carboxylates. Such a glycosylation can be promoted by a series of met......

Using a Johnson-Claisen Rearrangement Strategy to Construct Azaindoles - A Streamlined and Concise Route for the Commercial Process of Fevipiprant

期刊: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2021; 2021 (31)

A novel and concise synthesis of the DP2 receptor antagonist Fevipiprant (NVP-QAW039) was developed. The initial research route was suffering from a l......

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