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?-Amyloid promotes platelet activation and activated platelets act as bridge between risk factors and Alzheimer?s disease

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 207 ()

Alzheimer's disease (AD) is an evolving challenge that places an enormous burden on families and society. The presence of obvious brain beta-amyloid (......

JIF:5.013

Exogenous Klotho ameliorates extracellular matrix degradation and angiogenesis in intervertebral disc degeneration via inhibition of the Rac1/ PAK1/MMP-2 signaling axis

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 207 ()

Intervertebral disc degeneration (IDD) is highly ubiquitous in the aged population and is an essential factor for low back pain and spinal disability.......

JIF:5.013

Cardioprotection of Klotho against myocardial infarction-induced heart failure through inducing autophagy

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 207 ()

Myocardial infarction (MI) is the most common cause of heart failure (HF) worldwide. The aim of this study was to investigate the role of Klotho in ca......

JIF:5.013

Potential genetic biomarkers are found to be associated with both cognitive function and blood pressure: A bivariate genome-wide association analysis

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 204 ()

A bivariate genome-wide association study was conducted in 137 pairs of twins to explore the shared genetic loci between cognition and blood pressure ......

JIF:5.013

The SIRT1 activator SRT2104 promotes BMP9-induced osteogenic and angiogenic differentiation in mesenchymal stem cells

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 207 ()

Bone defects resulting from trauma, bone tumors, infections and skeletal abnormalities are a common osteo-porotic condition with respect to clinical t......

JIF:5.013

Ileal FXR-FGF15/19 signaling activation improves skeletal muscle loss in aged mice

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 202 ()

Sarcopenia is the age-related decrease in skeletal muscle mass, and current therapies for this disease are ineffective. We previously showed that ilea......

JIF:5.013

Inhibition of Cpt1a alleviates oxidative stress-induced chondrocyte senescence via regulating mitochondrial dysfunction and activating mitophagy

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 205 ()

Osteoarthritis (OA) is an age-related chronic degenerative disease, and chondrocyte senescence has been established to play an important role in the p......

JIF:5.013

Cyanidin-3-O-glucoside promotes stress tolerance and lifespan extension of Caenorhabditis elegans exposed to polystyrene via DAF-16 pathway

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 207 ()

Microplastic pollution has attracted growing attention due to its prevalent and persistent exposure to general population through the food chain, but ......

JIF:5.013

Inhibitor GSK690693 extends Drosophila lifespan via reduce AKT signaling pathway

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 202 ()

Aging is a process involving physiological changes that lead to the decline of biological functions of various tissues and organs of the body. Therefo......

JIF:5.013

Blood donation improves skin aging through the reduction of iron deposits and the increase of TGF-? 1 in elderly skin

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 205 ()

Skin aging is characterized by a wide range of physiological and structural changes, including wrinkling, dyschromia, and roughness, as well as the re......

JIF:5.013

Spatiotemporal monitoring of NAD(+) metabolism with fluorescent biosensors

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2022; 204 ()

Nicotinamide adenine dinucleotide (NAD+) plays vital roles in cell metabolism, cell signaling, and gene expression regulation. NAD+ shows intricate su......

JIF:5.013

Pseudoginsenoside-F11 ameliorates okadiac acid-induced learning and memory impairment in rats via modulating protein phosphatase 2A

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2021; 197 ()

We have reported that pseudoginsenoside-F11 (PF11) can significantly improve the cognitive impairments in several Alzheimer's disease (AD) models, but......

Role and mechanism of TXNIP in ageing-related renal fibrosis

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2021; 196 ()

Kidney ageing, which is always accompanied by renal fibrosis, drives the progression of renal fibrosis. Thioredoxin-interacting protein (TXNIP) is an ......

A geroscience approach for Parkinson ' s disease: Conceptual framework and design of PROPAG-AGEING project

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2021; 194 ()

Advanced age is the major risk factor for idiopathic Parkinson's disease (PD), but to date the biological relationship between PD and ageing remains e......

Molecular mechanisms of altered adult hippocampal neurogenesis in Alzheimer?s disease

期刊: MECHANISMS OF AGEING AND DEVELOPMENT, 2021; 195 ()

Alzheimer?s disease (AD) is the most common cause of dementia globally. AD is a progressive neurodegenerative disorder, eventually manifesting as seve......

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