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Anti-inflammatory, antinociceptive, and vasorelaxant effects of a new pyrazole compound 5-(1-(2-fluorophenyl)-1H-pyrazol-4-yl)-1H-tetrazole: role of NO/cGMP pathway and calcium channels

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2023; 101 (5)

Molecular modification of compounds remains important strategy towards the discovery of new drugs. In this sense, this study presents a new pyrazole d......

Therapeutic effect of ouabagenin, a novel liver X receptor agonist, on atherosclerosis in nonalcoholic steatohepatitis in SHRSP5/Dmcr rat model

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2023; 101 (9)

The liver X receptor (LXR) can enhance cholesterol transporters, which could remove excess cholesterol from foam cells in atheromas. LXR has two subty......

Bosentan attenuates sickle cell disease erythrocyte HbS polymerization and impaired deformability induced by endothelin-1

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2023; ()

The effects of endothelin-1 (ET-1) on erythrocytes from sickle cell disease (SCD) patients have been described, but mechanisms of ET-1 regarding prima......

Chronic intermittent hypobaric hypoxia ameliorates vascular reactivity through upregulating adiponectin expression of PVAT in metabolic syndrome rats

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2023; 101 (3)

Cumulating evidence demonstrated that chronic intermittent hypobaric hypoxia (CIHH) had beneficial effects on the body. This study investigated the ro......

Anticancer activity of sinapic acid by inducing apoptosis in HT-29 human colon cancer cell line

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2023; 101 (7)

Colorectal cancer is the third most lethal and fourth most commonly diagnosed cancer worldwide. Sinapic acid, a derivative of hydroxycinnamic acid, is......

Caloric restriction improves inflammation in different tissues of the Wistar rats with obesity and 2K1C renovascular hypertension

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2023; ()

Renovascular hypertension (RHV) is the cause of high blood pressure due to left renal ischemia, and obesity and hypertension cause an inflammatory res......

The impact of ionizing radiation compared to drug-induced immunological changes

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2023; ()

Ionizing radiation (IR) activates several signaling pathways. This study shows the impact of acute low-dose IR on crucial cytokines involved in cell-m......

SCH772984 ameliorates lipopolysaccharide-induced hypoglycemia in mice through reversing MEK/ERK/Foxo1-mediated gluconeogenesis suppression

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2023; ()

Lipopolysaccharide (LPS) results in a lethal hypoglycemic response. However, the main molecular mechanism involved in LPSinduced glucose metabolism di......

Preventive effects of antenatal CDP-choline in a rat model of neonatal hyperoxia-induced lung injury

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2023; 101 (2)

Antenatal steroid administration to pregnant women at risk of prematurity provides pulmonary maturation in infants, while it has limited effects on in......

Gallic acid markedly stimulates GLUT1-mediated glucose uptake by the AsPC-1 pancreatic cancer cell line

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2023; 101 (2)

Phenolic acids are recognized as chemopreventive and chemotherapeutic agents. Altered glucose and glutamine metabolism are recognized hallmarks of can......

The myokine decorin improves the cardiac function in a rat model of isoprenaline-induced myocardial infarction

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2023; 101 (6)

Myocardial infarction is a common cause of disability. Decorin is a myokine that has anti-inflammatory, anti-apoptotic effects. Some studies stated th......

Mechanical activation of vagal afferents involves opposing cation and TREK1 currents and NO regulation

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2023; 101 (10)

Vagal afferents convey signals of mechanical stimulation in the gut to the brain, which is essential for the regulation of food intake. However, ion c......

Vitamins E and A increase the passing of the P-gp substrate ivermectin into the brain in mice

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2023; 101 (9)

This study aimed to determine the effect of administration of oral vitamins A and E at different doses on plasma and brain concentrations of ivermecti......

Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor-KB and platelet aggregation in type 2 diabetic patients

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2023; ()

Platelet hyperactivity is one of the key factors implicated in the development and progression of diabetic vascular com-plications. Activated platelet......

Thyroid hormone induces restrictive cardiomyopathy in β1-adrenoceptor knockout mice

期刊: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2023; ()

The purpose of this study was to characterize the role of beta(1)-AR signaling and its cross-talk between cardiac renin-angiotensin system and thyroid......

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