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Emerging Therapies and Therapeutic Targets for Composite Liver Disease: NASH

期刊: CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2023; 23 (21)

Background: Liver diseases continue to destroy the lives of people, one of which is known as Non-alcoholic Steatohepatitis (NASH) that becomes a serio......

Chronic Hepatitis B Infection: Current and Emerging Therapeutic Strategies

期刊: CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2023; 23 (18)

The chronic infection of the hepatitis B virus (CHB) represents a major public health problem worldwide. Despite the availability of an effective prop......

Propolis: Antineoplastic Activity, Constituents, and Mechanisms of Action

期刊: CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2023; 23 (18)

Propolis is a beehive product with great pharmacological potential, including antineoplastic activity.Objectives The aim of this study is to provide a......

The Applications of CRISPR/Cas9 System for Urinary System Tumor

期刊: CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2023; 23 (10)

Tumors of the urinary system include those in the urinary and reproductive systems, of which tumors of the prostate, bladder, and kidney have the high......

Metal-organic Framework in Pharmaceutical Drug Delivery

期刊: CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2023; 23 (13)

Metal-organic frameworks (MOFs) are porous, crystalline materials made up of organic ligands and metal ions/metal clusters linked by coordinative bond......

Research Progress on Small-molecule Inhibitors of Protein Arginine Methyltransferase 5 (PRMT5) for Treating Cancer

期刊: CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2023; 23 (21)

Background: The protein arginine methyltransferase family includes nine members, with PRMT5 being the major type II arginine methyltransferase. PRMT5 ......

Orchids of Dibru-Saikhowa: A Systematic Review on Their Traditional Use, Pharmacological Activity and Phytochemistry

期刊: CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2023; 23 (24)

Background Dibru-Saikhowa National Park and Biosphere Reserve (DSNPBR), Assam, India, is a part of biodiversity hotspots and a store house of many orc......

Non-vesicular Lipid Transport Machinery in Trichomonas vaginalis: Novel Drug Targets against Trichomoniasis

期刊: CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2023; 23 (7)

Eukaryotic cells have separate membrane-enclosed organelles with distinct biochemical identities and specialized functions. The unique characteristics......

A Review of Computational Approaches Targeting SARS-CoV-2 Main Protease to the Discovery of New Potential Antiviral Compounds

期刊: CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2023; 23 (1)

The new pandemic caused by the coronavirus (SARS-CoV-2) has become the biggest challenge that the world is facing today. It has been creating a devast......

Effect of Withaferin-A, Withanone, and Caffeic Acid Phenethyl Ester on DNA Methyltransferases: Potential in Epigenetic Cancer Therapy

期刊: CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2023; ()

Background DNA methyltransferases (DNMTs) have been reported to be potential drug targets in various cancers. The major hurdle in inhibiting DNMTs is ......

Natural Products and Biological Activities of Plants from Genus Morus: 2011-2023

期刊: CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2023; 23 (28)

Species of genus Morus (family Moraceae) have been used as traditional medicinal and edible resources since ancient times. Genus Morus has been acknow......

QSAR Studies of Nitric Oxide Synthase Inhibitors

期刊: CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2023; 23 (29)

Background Nitric oxide is a free radical bioregulator controlling homeostasis, vasodilation, and inhibition of platelet aggregation, significantly im......

Surface Functionalization of Extracellular Vesicles with Nucleic Acids towards Biomedical Applications

期刊: CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2023; 23 (14)

Extracellular vesicles (EVs) are lipid bilayer-delimited particles secreted by cells and are regarded as a promising class of nanocarriers for biomedi......

A Review of Phytochemical and Pharmacological Properties of Alpinia malaccensis (Burm. F.) Roscoe. (Zingiberaceae)

期刊: CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2023; 23 (20)

Alpinia malaccensis, commonly known as Malacca ginger and Rankihiriya, is an important medicinal plant of Zingiberaceae. It is native to Indonesia and......

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