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Carboxymethyl starch as a solid dispersion carrier to enhance the dissolution and bioavailability of piperine and 18β-glycyrrhetinic acid

期刊: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2023; 49 (1)

Objective: To investigate the applicability of carboxymethyl starch (CMS) as a carrier to prepare solid dispersions (SDs) of piperine (PIP) and 18 bet......

Preparation and evaluation in vitro and in vivo of pristinamycin enteric-coated granules based on albumin nanoparticles

期刊: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2023; 49 (1)

ContextThe purpose of this study was to prepare enteric-coated particles based on albumin nanoparticles (NPs) using a mixture of PIA albumin NPs freez......

Preparation and evaluation of a lipid-based drug delivery system to improve valsartan oral bioavailability: pharmacokinetic and pharmacodynamic analysis

期刊: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2023; ()

Antihypertensive treatment reduces the risk of cardiovascular complications in patients with high mortality with hypertension. Valsartan is highly sel......

Breaking barriers: bilosomes gel potentials to pave the way for transdermal breast cancer treatment with Tamoxifen

期刊: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2023; ()

ObjectiveBreast cancer affects women globally, regardless of age or location. On the other hand, Tamoxifen (TXN), a class II biopharmaceutical drug is......

Study on co-delivery of pemetrexed disodium and Bcl-2 siRNA by poly-γ-glutamic acid-modified cationic liposomes for the inhibition of NSCLC

期刊: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2023; 49 (1)

Due to the complexity of the pathophysiology of non-small cell lung cancer (NSCLC) and the susceptibility of single chemotherapy to drug resistance, t......

The folate-linked chitosan-coated Kaempferol/HSA nano-transporters (FCKH-NTs) as the selective apoptotic inducer in human MCF-7 breast cancer cell line

期刊: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2023; 49 (10)

BackgroundKaempferol, the natural bioactive flavonoid, has been utilized as an efficient anti-breast cancer compound. In the current study, the Kaempf......

Design and fabrication of Sesamol-loaded transfersomal gel for wound healing: physicochemical characterization and in-vivo evaluation

期刊: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2023; 49 (2)

ObjectiveIn the present study, an attempt has been made to develop SL-loaded transfersomal gel for the effective treatment of delayed wound healing.Si......

Targeted delivery of epirubicin to breast cancer cells using poly-aptamer DNA nanocarriers prepared by the RCA method with multiple repeats of aptamers of FOXM1 and AS1411

期刊: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2023; 49 (3)

ObjectiveWe evaluated the DNA nanocarriers synthesized by rolling circle amplification (RCA), composed of multiple repeats of AS1411 and FOXM1 aptamer......

pH-Responsive and liver-targeting drug delivery system for combination delivery of artesunate with arsenic trioxide prodrug against hepatocellular carcinoma

期刊: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2023; 49 (8)

ObjectiveArsenic trioxide (ATO) exerts therapeutic effects on various solid tumors, and artesunate (ART) synergizes with antitumor drugs. We herein co......

Preparation and in vitro characterization of curcumin loaded Chitosan-Hyaluronic acid polyelectrolyte complex based hydrogels

期刊: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2023; 49 (10)

Objective: The manuscript aims to prepare and comprehensively characterize curcumin-loaded chitosan-hyaluronic acid polyelectrolyte complex (PEC) hydr......

Nasal residence time and rheological properties of a new bentonite-based thixotropic gel emulsion nasal spray - AM-301

期刊: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2023; 49 (1)

ObjectiveThe present work provides characterization of rheological properties of a new bentonite-based thixotropic gel emulsion nasal spray (AM-301), ......

Sangelose-based gels and films: effects of glycerol and α-cyclodextrin and their pharmaceutical application

期刊: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2023; 49 (1)

Objective: To evaluate the possible application of Sangelose as an alternative to gelatin and carrageenan for the development of film substrates, and ......

Exploration of polymethacrylate and Hypromellose for the development of a non-sulfhydryl ACE inhibitor mucoadhesive system using Box-Behnken design: in-vitro and ex-vivo evaluation

期刊: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2023; 49 (1)

PurposeTo counteract early morning pathology like hypertension a time-dependent release of the drug is required. This study is focused to formulate a ......

Ginkgo biloba leaves extract's cosmeceutical evaluation: a preliminary assessment of human volunteers toward achieving improved skin conditions and rejuvenation

期刊: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2023; 49 (3)

BackgroundGinkgo biloba (GB) leaves extract is known to possess potent antioxidants and other bioactivities such as improved skin conditions and rejuv......

Systems pharmacology approach to explore the mechanisms of shufeng Jiedu Capsule on treating H1N1 infection

期刊: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2023; 49 (6)

BackgroundInfluenza caused by the H1N1 virus still affects human health. There is currently no effective strategy against H1N1 virus infection. The pr......

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