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Polystyrene nanoplastics potentiate the development of hepatic fibrosis in high fat diet fed mice

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (2)

Polystyrene nanoparticles (PS-NPs) as an issue of global environmental concern, have been shown to induce hepatic toxicity via triggering oxidative in......

JIF:3.779

Inhibition of FAM83D displays antitumor effects in glioblastoma via down-regulation of the AKT/Wnt/beta-catenin pathway

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (6)

Up-regulation of family with sequence similarity 83 member D (FAM83D) has been acknowledged as a vital contributor for the carcinogenesis of numerous ......

JIF:3.779

Restraint of FAM60A has a cancer-inhibiting role in pancreatic carcinoma via the effects on the Akt/GSK-3 beta/beta-catenin signaling pathway

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (6)

Family with sequence similarity 60A (FAM60A) has been reported as a new cancer-related protein that affects the malignant progression of some cancers.......

JIF:3.779

Effects of bis (2-butoxyethyl) phthalate on adrenocortical function in male rats in puberty partially via down-regulating NR5A1/NR4A1/NR4A2 pathways

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (10)

Phthalates may interfere with the biosynthesis of steroid hormones in the adrenal cortex. Bis (2-butoxyethyl) phthalate (BBOP) is a phthalate containi......

JIF:3.779

The biomechanistic aspects of renal cortical injury induced by diesel exhaust particles in rats and the renoprotective contribution of quercetin pretreatment: Histological and biochemical study

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (2)

Although several studies have reported a toxic effect of diesel exhaust particles (DEP) exposure on the kidney tissues, the involvement of autophagy/N......

JIF:3.779

RNF168 suppresses the cancer stem cell-like traits of nonsmall cell lung cancer cells by mediating RhoC ubiquitination

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (3)

The critical roles of E3 ubiquitin ligase RNF168 have been widely revealed in various tumors, however, its roles in lung cancer progression are still ......

JIF:3.779

Uranium induces kidney cells apoptosis via reactive oxygen species generation, endoplasmic reticulum stress and inhibition of PI3K/AKT/mTOR signaling in culture

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (4)

Uranium (U) induces generation of excessive intracellular reactive oxygen species (ROS), which is generally considered as a possible mediator of U-tri......

JIF:3.779

Nimbolide retards T cell lymphoma progression by altering apoptosis, glucose metabolism, pH regulation, and ROS homeostasis

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (6)

Nimbolide is reported as one of the potential anticancer candidates of the neem tree (Azadirachta indica A. Juss). The cytotoxic action of nimbolide h......

JIF:3.779

Sesamol protects against aluminum oxide nanoparticles-induced hepatorenal toxicity in rats via modulation of oxidative stress, inflammation, apoptosis, and DNA damage

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (8)

Aluminum oxide nanoparticles (Al2O3-NPs) are exceedingly used in various industrial and commercial applications, providing growing concerns about thei......

JIF:3.779

Protective effect of wogonin on inflammatory responses in BisGMA-treated macrophages through the inhibition of MAPK and NF kappa B pathways

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (12)

Composites, resins, and sealants that are commonly used in orthopedics and dentistry are based on 2,2-bis[p-(2 '-hydroxy-3 '-methacryloxypropoxy)pheny......

JIF:3.779

Estrogen receptor-alpha 36 is involved in diallyl sulfide-induced inhibition of malignant growth of HepG2 and Huh7 hepatocellular carcinoma cells

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (2)

Hepatocellular carcinoma (HCC) is a highly malignant disease that currently lacks effective treatment. Epidemiological studies have suggested the prev......

JIF:3.779

MiR-125b enhances doxorubicin-induced cardiotoxicity by suppressing the nucleus-cytoplasmic translocation of YAP via targeting STARD13

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (4)

The clinical application of doxorubicin (Dox) is limited due to its cardiotoxicity, while the pathogenesis remains to be fully understood. Recent stud......

JIF:3.779

Hsp70 overexpression in Drosophila hemocytes attenuates benzene-induced immune and developmental toxicity via regulating ROS/JNK signaling pathway

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (7)

Benzene, a ubiquitous environmental chemical, is known to cause immune dysfunction and developmental defects. This study aims to investigate the relat......

JIF:3.779

Effects of mammalian target of rapamycin and aryl hydrocarbon receptor-mediating autophagy signaling on the balance of Th17/Treg cells during perinatal bisphenol A exposure in female offspring mice

期刊: ENVIRONMENTAL TOXICOLOGY, 2022; 37 (7)

Bisphenol A (BPA)'s immunotoxic properties have received increasing interest, which can lead to immune dysfunction and related disease development. Ho......

JIF:3.779

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