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Roquin-dependent gene regulation in immune-mediated diseases and future therapies

期刊: INTERNATIONAL IMMUNOLOGY, 2023; 35 (4)

The RNA-binding proteins Roquin-1/2 and Regnase-1 exert essential regulation by controlling pro-inflammatory mRNA expression to prevent autoimmune dis......

The bZIP transcription factor BATF3/ZIP-10 suppresses innate immunity by attenuating PMK-1/p38 signaling

期刊: INTERNATIONAL IMMUNOLOGY, 2023; 35 (4)

Innate immunity is the first line of host defense against pathogenic invasion in metazoans. The transcription factor basic leucine zipper transcriptio......

Dupuytren's contracture-associated SNPs increase SFRP4 expression in non-immune cells including fibroblasts to enhance inflammation development

期刊: INTERNATIONAL IMMUNOLOGY, 2023; 35 (7)

Dupuytren's contracture (DC) is an inflammatory fibrosis characterized by fibroproliferative disorders of the palmar aponeurosis, for which there is n......

Maternal antibody repertoire restriction modulates the development of lupus-like disease in BXSB offspring

期刊: INTERNATIONAL IMMUNOLOGY, 2023; 35 (2)

Systemic lupus erythematosus (SLE) is a complex autoimmune disease that has a strong preference for women of child-bearing age. Maternal factors play ......

Necessity of HuR/ELAVL1 for the activation-induced cytidine deaminase-dependent decrease in topoisomerase 1 in antibody diversification

期刊: INTERNATIONAL IMMUNOLOGY, 2023; 35 (8)

Activation-induced cytidine deaminase (AID)-dependent DNA cleavage is the initial event of antibody gene-diversification processes such as class switc......

Activation of nucleotide-binding oligomerization domain 2 by muramyl dipeptide negatively regulates Toll-like receptor 9-mediated colonic inflammation through the induction of deubiquitinating enzyme A expression

期刊: INTERNATIONAL IMMUNOLOGY, 2023; 35 (2)

Mutations in nucleotide-binding oligomerization domain 2 (NOD2) are associated with Crohn's disease (CD). Although NOD2 activation contributes to the ......

Zoobiquity experiments show the importance of the local MMP9-plasminogen axis in inflammatory bowel diseases in both dogs and patients

期刊: INTERNATIONAL IMMUNOLOGY, 2023; 35 (7)

Using a zoobiquity concept, we directly connect animal phenotypes to a human disease mechanism: the reduction of local plasminogen levels caused by ma......

Contributions of the N-terminal flanking residues of an antigenic peptide from the Japanese cedar pollen allergen Cry j 1 to the T-cell activation by HLA-DP5

期刊: INTERNATIONAL IMMUNOLOGY, 2023; ()

Cry j 1 is a major allergen present in Japanese cedar (Cryptomeria japonica) pollens. Peptides with the core sequence of KVTVAFNQF from Cry j 1 ('pCj1......

Vaccination with the Omicron spike RBD boosts broadly neutralizing antibody levels and confers sustained protection even after acquiring immunity to the original antigen

期刊: INTERNATIONAL IMMUNOLOGY, 2023; 35 (4)

The immune evasion of SARS-CoV-2 Omicron variants caused by multiple amino acid replacements in the receptor-binding domain (RBD) of the spike protein......

Subcutaneous immunisation with zymosan generates mucosal IgA-eliciting memory and protects mice from heterologous influenza virus infection

期刊: INTERNATIONAL IMMUNOLOGY, 2023; 35 (8)

Immunoglobulin A (IgA) is the most abundant isotype of antibodies and provides a first line of defense at the mucosa against pathogens invading the ho......

The proliferative activity levels of each immune cell population evaluated by mass cytometry are linked to the clinical phenotypes of systemic lupus erythematosus

期刊: INTERNATIONAL IMMUNOLOGY, 2023; 35 (1)

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease, and many peripheral immune cell populations (ICPs) are thought to be altered......

Exploring novel functions of BACH2 in the acquisition of antigen-specific antibodies

期刊: INTERNATIONAL IMMUNOLOGY, 2023; 35 (6)

BACH2 [BTB (broad-complex, tramtrak and bric a brac) and CNC (cap 'n' collar) homolog 2] is known as a transcriptional repressor and broadly functions......

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