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Biochanin-A alleviates fibrosis and inflammation in cardiac injury in mice

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2023; 37 (7)

Biochanin-A (BCA), is an isoflavonoid, exhibits protective effects against various diseases. This study was conducted to observe the effect of BCA on ......

The therapeutic effect of silibinin against 5-fluorouracil-induced ovarian toxicity in rats

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2023; 37 (9)

5-Fluorouracil (5-FU) is a fluoropyrimidine group antineoplastic drug with antimetabolite properties and ovotoxicity is one of the most important side......

Pharmacotherapeutic values of berberine: A Chinese herbal medicine for the human cancer management

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2023; 37 (3)

Berberine (BBR), a traditional Chinese phytomedicine extracted from various parts of Berberis plants, is an isoquinoline alkaloid used for centuries t......

Naringenin alleviate reproductive toxicity evoked by lead acetate via attenuation of sperm profile and biochemical alterations in male Wistar rat: Involvement of TGFβ/AKT/mTOR pathway

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2023; 37 (6)

Exposure to Lead -causes testicular dysfunction through oxidative stress, inflammation, and apoptosis; however, naringenin (NGN) therapeutic impact ag......

Quercetin handles cellular oxidant/antioxidant systems and mitigates immunosenescence hallmarks in human PBMCs: An in vitro study

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2023; 37 (7)

Immunosenescence, oxidative stress, and low vaccine efficacy are important symptoms of aging. The goal of our study was to test if quercetin had antia......

Daboxin P, a phospholipase A2 of Indian Daboia russelii venom, modulates thrombin-mediated platelet aggregation

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2023; 37 (11)

Daboxin P, reported earlier from the venom of Daboia russellii, disturbs the blood coagulation cascade by targeting factor X and factor Xa. The presen......

α-bisabolol β-d-fucopyranoside (ABFP) ameliorates scopolamine-induced memory deficits through cholinesterase inhibition and attenuation of oxidative stress in zebrafish (Danio rerio)

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2023; ()

Alzheimer's disease (AD) is one of the major devastating neurodegenerative disorders associated with the gradual decline of an individual's memory, co......

Aggressive-like behaviour and neurocognitive impairment in alcohol herbal mixture-fed mice are associated with increased neuroinflammation and neuronal apoptosis in the prefrontal cortex

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2023; 37 (2)

Alcohol-induced aggression and related violence is a serious and common social problem globally. Alcohol use is increasingly found in the form of alco......

MicroRNAs target the PI3K/Akt/p53 and the Sirt1/Nrf2 signaling pathways in doxorubicin-induced cardiotoxicity

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2023; 37 (2)

Doxorubicin (DOX) is used as a chemotherapeutic agent in the treatment of solid tumors. Irreversible cardiotoxicity is the major limitation in the cli......

Susceptibility of male reproductive system to bisphenol A, an endocrine disruptor: Updates from epidemiological and experimental evidence

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2023; 37 (4)

Bisphenol A (BPA) is an omnipresent environmental pollutant. Despite being restrictions in-force for its utilization, it is widely being used in the p......

Role of ATP5G3 in sodium nitroprusside-induced cell death in cervical carcinoma cells

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2023; 37 (3)

We identified a gene, subunit C3 (ATP5G3) of mitochondrial ATP synthase, that displayed changes in gene expression under oxidative stress. We examined......

Proteomics analysis of meclofenamic acid-treated small cell lung carcinoma cells revealed changes in cellular energy metabolism for cancer cell survival

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2023; 37 (4)

Small cell lung carcinoma (SCLC) is a highly aggressive cancer with low survival rate. Although initial response to chemotherapy in SCLC patients is w......

The capsaicinoid nonivamide suppresses the inflammatory response and attenuates the progression of steatosis in a NAFLD-rat model

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2023; 37 (3)

Nonalcoholic fatty liver disease (NAFLD) is relatively associated with comorbidities in obesity and metabolic inflammation. Low-grade inflammation fol......

Apigenin protects from hepatorenal damage caused by lead acetate in rats

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2023; 37 (3)

Exposure to lead (Pb) is associated with serious health problems including hepatorenal toxicity. Apigenin is a natural-sourced flavonoid with promisin......

N-Propargylic β-enaminones in breast cancer cells: Cytotoxicity, apoptosis, and cell cycle analyses

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2023; 37 (4)

Breast cancer is one of the most common cancers worldwide and the discovery of new cytotoxic agents is needed. Enaminones are regarded to be a signifi......

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