期刊： JOURNAL OF GENERAL PHYSIOLOGY, 2023; 155 (8)
JGP study reveals how interactions with pore-helix residues control filter inactivation in the prokaryotic potassium channel MthK. JGP study (Kopec et......
期刊： JOURNAL OF GENERAL PHYSIOLOGY, 2023; 155 (9)
Voltage-gated sodium channels (Na-v) are key players in excitable tissues with the capability to generate and propagate action potentials. Mutations i......
期刊： JOURNAL OF GENERAL PHYSIOLOGY, 2023; 155 (10)
JGP study (Komondor et al. 2023. J. Gen. Physiol. https://doi.org/10.1085/jgp.202213258) reveals that conventional PLC activation pathways are not req......
期刊： JOURNAL OF GENERAL PHYSIOLOGY, 2023; 155 (12)
Calcium binding to troponin, with subsequent displacement of its linked tropomyosin molecule on the thin filament surface, cooperates with myosin bind......
期刊： JOURNAL OF GENERAL PHYSIOLOGY, 2023; 156 (1)
TRPV1 ion channels are important players in thermal and chemical sensation and have roles in pathological states. In this work, Garcia-avila et al. em......
期刊： JOURNAL OF GENERAL PHYSIOLOGY, 2023; 155 (5)
The selective exchange of ions across cellular membranes is a vital biological process. Ca2+-mediated signaling is implicated in a broad array of phys......
期刊： JOURNAL OF GENERAL PHYSIOLOGY, 2023; 155 (4)
CFTR chloride channel mutations cause the lethal and incurable disease cystic fibrosis (CF). CFTR is activated by phosphorylation, and phosphorylated ......
期刊： JOURNAL OF GENERAL PHYSIOLOGY, 2023; 155 (5)
KCNQ1 voltage-gated K+ channels are involved in a wide variety of fundamental physiological processes and exhibit the unique feature of being markedly......
期刊： JOURNAL OF GENERAL PHYSIOLOGY, 2023; 155 (12)
Ishii et al. analyze the microheating-induced sliding movements of reconstituted thin filaments in an in vitro motility assay. They find that the temp......
期刊： JOURNAL OF GENERAL PHYSIOLOGY, 2023; 155 (9)
JGP study (Hermanstyne et al. 2023. J. Gen. Physiol.) shows that Kv12-encoded K+ currents reduce the repetitive firing rates of SCN neurons at night, ......
期刊： JOURNAL OF GENERAL PHYSIOLOGY, 2023; 155 (12)
Murciano et al. present an assay to investigate PIEZO1 channels by combining planar patch clamp with mechanical stimulation. This technique will enabl......
期刊： JOURNAL OF GENERAL PHYSIOLOGY, 2023; 155 (4)
Tight control of skeletal muscle contractile activation is secured by the excitation-contraction (EC) coupling protein complex, a molecular machinery ......
期刊： JOURNAL OF GENERAL PHYSIOLOGY, 2023; 155 (6)
Light-controlled availability for phosphorylation reveals dominant roles of select R-domain serines in CFTR channel activation.
期刊： JOURNAL OF GENERAL PHYSIOLOGY, 2023; 155 (5)
In central synapses, spontaneous transmitter release observed in the absence of action potential firing is often considered as a random process lackin......
