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Dietary squalene supplementation decreases triglyceride species and modifies phospholipid lipidomic profile in the liver of a porcine model of non-alcoholic steatohepatitis

期刊: JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2023; 112 ()

Squalene is a key minor component of virgin olive oil, the main source of fat in the Mediterranean diet, and had shown to improve the liver metabolism......

Perinatal iron deficiency causes sex-dependent alterations in renal retinoic acid signaling and nephrogenesis

期刊: JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2023; 112 ()

Long-term alterations in kidney structure and function have been observed in offspring exposed to perinatal stressors such as iron deficiency (ID), al......

Sugar-sweetene d b everages exacerbate high-fat diet-induced inflammatory bowel disease by altering the gut microbiome

期刊: JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2023; 113 ()

High-fat diets (HFDs) and frequent consumption of sugar-sweetened beverages (SSBs) are potential contributors to increasing inflammatory bowel dis-eas......

Combined prenatal to postnatal protein restriction augments protein quality control processes and proteolysis in the muscle of rat offspring

期刊: JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2023; 114 ()

Several human epidemiological and animal studies suggest that a maternal low-protein (MLP) diet affects skeletal muscle (SM) health in the offspring. ......

Targeted tumor killing by pomegranate polyphenols: Pro-oxidant role of a classical antioxidant

期刊: JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2023; 115 ()

One of the key biochemical features that distinguish a cancer cell from normal cells is its persistent pro-oxidative state that leads to intrinsic oxi......

Adipose tissue angiogenesis genes are down-regulated by grape polyphenols supplementation during a human overfeeding trial

期刊: JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2023; 117 ()

The adaptive response to overfeeding is associated with profound modifications of gene expression in adipose tissue to support lipid storage and weigh......

Availability of abundant thiamine determines efficiency of thermogenic activation in human neck area derived adipocytes

期刊: JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2023; 119 ()

Brown/beige adipocytes express uncoupling protein-1 (UCP1) that enables them to dissipate energy as heat. Systematic activation of this process can al......

Common and ethnic-specific genetic determinants of hemoglobin concentration between Taiwanese Han Chinese and European Whites: findings from comparative two-stage genome-wide association studies

期刊: JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2023; 111 ()

Human iron nutrition is a result of interplays between genetic and environmental factors. However, there has been scarcity of data on the genetic vari......

Dietary supplementation with nicotinamide riboside improves fetal growth under hypoglycemia

期刊: JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2023; 116 ()

Nicotinamide riboside (NR) is considered a super-supplement that prevents obesity and diabetes. While NR has been investigated for various effects dep......

The role of selenium in shaping mice brain metabolome and selenoproteome through the gut-brain axis by combining metabolomics, metallomics, gene expression, and amplicon sequencing

期刊: JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2023; 117 ()

Selenium (Se) is a trace element crucial for human health. Recently, the impact of Se supplementation on gut microbiota has been pointed out as well a......

The early impact of diets enriched with saturated and unsaturated fatty acids on intestinal inflammation and tight junctions

期刊: JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2023; 119 ()

The gut has been suggested as the first organ to be affected by unbalanced diets contributing to the obesogenic process. This study aimed to test a sh......

Aspartame consumption during pregnancy impairs placenta growth in mice through sweet taste receptor-reactive oxygen species-dependent pathway

期刊: JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2023; 113 ()

The prevalence of obesity has risen dramatically over recent years, and so has the prevalence of adverse obesity-associated pregnancy outcomes. To com......

Delayed feeding of a high-sucrose diet led to increased body weight by affecting the circadian rhythm of body temperature and hepatic lipid-metabolism genes in rats

期刊: JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2023; 111 ()

Skipping breakfast is an irregular feeding behavior, typically in young people. In our previous study, we established a 4 h-delayed feeding protocol f......

Maternal omega-3 LC-PUFA supplementation programs an improved bone mass in the offspring with a more pronounced effect in females than males at adulthood

期刊: JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2023; 113 ()

Early balanced nutrition is vital in achieving optimal skeletal mass and its maintenance. Although a lower omega-6 (n-6): omega-3 (n-3) long-chain pol......

Investigating the plasma-liver-brain axis of omega-3 fatty acid metabolism in mouse knock-in for the human apolipoprotein E epsilon 4 allele

期刊: JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2023; 111 ()

The metabolism of docosahexaenoic acid (DHA), an omega-3 fatty acid, is different in carriers of APOE4, the main genetic risk factor for late-onset Al......

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