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Schwann cell functions in peripheral nerve development and repair

期刊: NEUROBIOLOGY OF DISEASE, 2023; 176 ()

The glial cell of the peripheral nervous system (PNS), the Schwann cell (SC), counts among the most multifaceted cells of the body. During development......

The transcriptomic landscape of neurons carrying PSEN1 mutations reveals changes in extracellular matrix components and non-coding gene expression

期刊: NEUROBIOLOGY OF DISEASE, 2023; 178 ()

Alzheimer's disease (AD) is a progressive and irreversible brain disorder, which can occur either sporadically, due to a complex combination of enviro......

Machado Joseph disease severity is linked with gut microbiota alterations in transgenic mice

期刊: NEUROBIOLOGY OF DISEASE, 2023; 179 ()

Emerging evidence suggests the presence of bidirectional interactions between the central nervous system and gut microbiota that may contribute to the......

GABAergic circuits drive focal seizures

期刊: NEUROBIOLOGY OF DISEASE, 2023; 180 ()

Epilepsy is based on abnormal neuronal activities that have historically been suggested to arise from an excess of excitation and a defect of inhibiti......

Adult mice with noise-induced hearing loss exhibited temporal ordering memory deficits accompanied by microglia-associated neuroplastic changes in the medial prefrontal cortex

期刊: NEUROBIOLOGY OF DISEASE, 2023; 183 ()

Acquired peripheral hearing loss in midlife is considered the primary modifiable risk factor for dementia, while the underlying pathological mechanism......

Super-resolution imaging pinpoints the periodic ultrastructure at the human node of Ranvier and its disruption in patients with polyneuropathy

期刊: NEUROBIOLOGY OF DISEASE, 2023; 182 ()

The node of Ranvier is the key element in saltatory conduction along myelinated axons, but its specific protein organization remains elusive in the hu......

Liquid-liquid phase separation of tau: Driving forces, regulation, and biological implications

期刊: NEUROBIOLOGY OF DISEASE, 2023; 183 ()

The past 15 years have witnessed an explosion in the studies of biomolecular condensates that are implicated in numerous biological processes and play......

Delayed postnatal brain development and ontogenesis of behavior and cognition in a mouse model of intellectual disability

期刊: NEUROBIOLOGY OF DISEASE, 2023; 183 ()

Intellectual disability (ID) is a neurodevelopmental disorder associated with impaired cognitive and adaptive behaviors and represents a major medical......

Does seizure propagate within or across intrinsic brain networks? An intracranial EEG study

期刊: NEUROBIOLOGY OF DISEASE, 2023; 184 ()

Background: Understanding the spatiotemporal propagation profiles of seizures is crucial for the preoperative assessment of epilepsy patients. The pre......

Progressive human-like tauopathy with downstream neurodegeneration and neurovascular compromise in a transgenic rat model

期刊: NEUROBIOLOGY OF DISEASE, 2023; 184 ()

Tauopathies, including frontotemporal dementia (FTD) and Alzheimer's disease (AD), clinically present with progressive cognitive decline and the depos......

Prolonged and specific spatial training during adolescence reverses adult hippocampal network impairments in a mouse model of fragile X syndrome

期刊: NEUROBIOLOGY OF DISEASE, 2023; 185 ()

The fragile X syndrome (FXS) is the leading monogenetic cause of cognitive impairment and autism. A hallmark of FXS in patients and the FXS mouse mode......

TMEM175: A lysosomal ion channel associated with neurological diseases

期刊: NEUROBIOLOGY OF DISEASE, 2023; 185 ()

Lysosomes are acidic intracellular organelles with autophagic functions that are critical for protein degradation and mitochondrial homeostasis, while......

VPS13A knockdown impairs corticostriatal synaptic plasticity and locomotor behavior in a new mouse model of chorea-acanthocytosis

期刊: NEUROBIOLOGY OF DISEASE, 2023; 187 ()

Chorea-acanthocytosis (ChAc) is an inherited neurodegenerative movement disorder caused by VPS13A gene mutations leading to the absence of protein exp......

Non-invasive biomarkers for mild cognitive impairment and Alzheimer's disease

期刊: NEUROBIOLOGY OF DISEASE, 2023; 187 ()

Alzheimer's disease is the most common type of dementia in the elderly. It is a progressive degenerative disorder that may begin to develop up to 15 y......

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