期刊： ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2023; ()
Without the use of chemical oxidants and metal catalysts, an aqueous electrochemical synthesis of 5-trifluoromethyluracil in batch and continuous flow......
期刊： ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2023; 27 (5)
Here, we report a novel, efficient ruthenium-catalyzed direct asymmetric reductive amination of an alpha-alkoxy ketone, a structural motif for which i......
期刊： ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2023; 27 (6)
Preparation of and carrying out chemicalreactions often requireconsiderable laboratory space. Miniaturization of chemical equipmentand reducing labora......
期刊： ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2023; 27 (7)
The tablet-based catalytic systems offer various advantagessuchas improved stability, ease of handling, and dosage delivery of transitionmetal catalys......
期刊： ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2023; ()
Optimization of bifunctional Ni catalysts was performed to enhance the catalytic performance in the one-pot synthesis of commercially valuable menthol......
期刊： ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2023; 27 (7)
The finding that the widely used peptide coupling reagents DIC and Oxyma form the toxic H-CN () has prompted studies aimed at H-CN minimization, attai......
期刊： ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2023; 27 (7)
Pharmaceutical R & D is increasingly employing data-drivenapproacheswith specialized process analytical technology (PAT) tools to developprocesses......
期刊： ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2023; 27 (8)
A change to EU law is proposed that would lead to a banon manufacture,supply, and use of most per- and polyfluorinated alkyl substance (PFAS)materials......
期刊： ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2023; ()
Gaucher's disease (GD) is a rare genetic disorder that falls under the category of lysosomal storage diseases (LSDs) and is caused by the defective pr......
期刊： ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2023; ()
SHEN26, a 5 '-cyclohexane-carboxylate prodrug of the nucleoside analog GS-441524, is a potent RdRp inhibitor currently undergoing phase III clinical t......
期刊： ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2023; 28 (1)
We reported the development of a novel synthetic process for Levodopa (1), which involves two simple chemical steps. The first step includes the react......
期刊： ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2023; 27 (7)
A cobalt-containing polysilane was readily obtained from the treatment of poly(monohydro)silane with Co2(CO)8 at 60 degrees C. The resulting polysilan......
期刊： ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2023; 27 (2)
CVN424 is a drug candidate, which is being investigated in clinical trials for the treatment of motor fluctuations associated with Parkinson's disease......
期刊： ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2023; 27 (4)
We report the use of continuous flow processing to enable the first two steps of a new route toward a cannabinoid receptor type 2 agonist, RG7774. Fir......
期刊： ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2023; 27 (10)
The detection of N-nitrosamine impuritiesin medicinesand the recent emergence of nitrosamine drug substance related impurities(NDSRIs) has posed a gre......
