期刊： TOXICOLOGIC PATHOLOGY, 2023; 51 (6)
Existing nervous system sampling and processing best practices for nonclinical general toxicity studies (GTS) were designed to assess test articles wi......
期刊： TOXICOLOGIC PATHOLOGY, 2023; 51 (6)
Data collected from approximately 1800 male and 1800 female Sprague-Dawley (SD) rats used in 104-week carcinogenicity studies were archived in a histo......
期刊： TOXICOLOGIC PATHOLOGY, 2023; 51 (3)
Branaplam is a splicing modulator previously under development as a therapeutic agent for Spinal Muscular Atrophy Type 1 and Huntington's disease. Bra......
期刊： TOXICOLOGIC PATHOLOGY, 2023; 51 (1-2)
The advancement of an investigational new drug in humans is a significant developmental milestone. In first-in-human (FIH)-enabling toxicology studies......
期刊： TOXICOLOGIC PATHOLOGY, 2023; 51 (1-2)
Ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate (HFPO-DA) is a short chain member of per- and polyfluoroalkyl substances (PFAS). To bet......
期刊： TOXICOLOGIC PATHOLOGY, 2023; 51 (5)
The minipig has been used as a non-rodent species in nonclinical toxicology studies, but little is known about amyloid A (AA) amyloidosis in this spec......
期刊： TOXICOLOGIC PATHOLOGY, 2023; ()
Drug-induced liver injury (DILI) remains a major concern in drug development from a patient safety perspective because it is the leading cause of acut......
期刊： TOXICOLOGIC PATHOLOGY, 2023; 51 (1-2)
Antimony trioxide (AT) is used as a flame retardant in fabrics and plastics. Occupational exposure in miners and smelters is mainly through inhalation......
期刊： TOXICOLOGIC PATHOLOGY, 2023; 51 (3)
Toxicologic/veterinary pathologists are working remotely from Good Laboratory Practice (GLP) test facilities (TFs) in increasing numbers, most commonl......
期刊： TOXICOLOGIC PATHOLOGY, 2023; ()
This article reviews the presentation given at the 2023 annual meeting of the Society of Toxicologic Pathology (STP) on liver toxicity observed with a......
期刊： TOXICOLOGIC PATHOLOGY, 2023; ()
In this study, we assessed the toxicity and toxicokinetics of racemic vigabatrin and its S- and R-enantiomers (vigabatrin consists of 50:50% of the tw......
期刊： TOXICOLOGIC PATHOLOGY, 2023; 51 (6)
This brief communication describes a rare spontaneous background lesion in the lower urinary tract of two male laboratory beagles. Proliferative lesio......
期刊： TOXICOLOGIC PATHOLOGY, 2023; 51 (6)
Digital pathology workflows in toxicologic pathology rely on whole slide images (WSIs) from histopathology slides. Inconsistent color reproduction by ......
期刊： TOXICOLOGIC PATHOLOGY, 2023; 51 (6)
The availability of large amounts of high-quality control data from tightly controlled regulated animal safety data has created the idea to re-use the......
