LMR-101, a novel derivative of propofol, exhibits potent anticonvulsant effects and possibly interacts with a novel target on gamma-aminobutyric acid type A receptors

Zhao, Y; An, L; Guo, SP; Huang, XX; Tian, HJ; Liu, L; Chen, T; Sun, X; Mei, QB; Wang, RT

Sun, X (corresponding author), Fudan Univ, Sch Pharm, Dept Nat Med, 826 Zhangheng Rd, Shanghai 201203, Peoples R China.; Mei, QB (corresponding author), Shanghai Inst Pharmaceut Ind, Pharmacol Res Ctr, 1111 Zhongshan North 1st Rd, Shanghai 200437, Peoples R China.; Wang, RT (corresponding author), XiAn Libang Pharmaceut Co, Dept New Drug Res, 69 Jinye Rd, Xian 710077, Shaanxi, Peoples R China.

EPILEPSIA, 2021; 62 (1): 238

Abstract

Objective: LMR-101 is a bisphenol derivative of propofol, a short-acting general anesthetic, which is also used to manage status epilepticus (SE). We ......

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