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Carboxymethyl chitosan prolongs adenovirus-mediated expression of IL-10 and ameliorates hepatic fibrosis in a mouse model

期刊: BIOENGINEERING & TRANSLATIONAL MEDICINE, 2022; 7 (3)

Effective and safe liver-directed gene therapy has great promise in treating a broad range of liver diseases. While adenoviral (Ad) vectors have been ......

Anterior substitutional urethroplasty using a biomimetic poly-l-lactide nanofiber membrane: Preclinical and clinical outcomes

期刊: BIOENGINEERING & TRANSLATIONAL MEDICINE, 2022; 7 (3)

The aim of this study is to investigate the feasibility and efficacy of a novel biomimetic poly-l-lactide (PLLA) nanofiber membrane in repairing anter......

Adaptive multi-degree-of-freedom in situ bioprinting robot for hair-follicle-inclusive skin repair: A preliminary study conducted in mice

期刊: BIOENGINEERING & TRANSLATIONAL MEDICINE, 2022; 7 (3)

Skin acts as an essential barrier, protecting organisms from their environment. For skin trauma caused by accidental injuries, rapid healing, personal......

Biofabricated macrophage and fibroblast membranes synergistically promote skin wound healing

期刊: BIOENGINEERING & TRANSLATIONAL MEDICINE, 2022; 7 (3)

Effective skin wound healing is a complex process involving anti-inflammation, fibrosis, matrix reconstruction, and angiogenesis. This work aimed to i......

Synergistic strategy with hyperthermia therapy based immunotherapy and engineered exosomes-liposomes targeted chemotherapy prevents tumor recurrence and metastasis in advanced breast cancer

期刊: BIOENGINEERING & TRANSLATIONAL MEDICINE, 2022; 7 (2)

Advanced breast cancer with recurrent and distal organ metastasis is aggressive and incurable. The current existing treatment strategies for advanced ......

Nanocomposite hydrogels for biomedical applications

期刊: BIOENGINEERING & TRANSLATIONAL MEDICINE, 2022; 7 (3)

Nanomaterials' unique structures at the nanometer level determine their incredible functions, and based on this, they can be widely used in the field ......

Novel nanofibrous membrane-supporting stem cell sheets for plasmid delivery and cell activation to accelerate wound healing

期刊: BIOENGINEERING & TRANSLATIONAL MEDICINE, 2022; 7 (1)

The integration of biomaterials with cells for high overall performances is vitally important in tissue engineering, as scaffold-free cell sheet lacks......

High-dose vitamin D metabolite delivery inhibits breast cancer metastasis

期刊: BIOENGINEERING & TRANSLATIONAL MEDICINE, 2022; 7 (1)

Besides its well-known benefits on human health, calcitriol, the hormonally active form of vitamin D-3, has been being evaluated in clinical trials as......

Multistage targeting and dual inhibiting strategies based on bioengineered tumor matrix microenvironment-mediated protein nanocages for enhancing cancer biotherapy

期刊: BIOENGINEERING & TRANSLATIONAL MEDICINE, 2022; 7 (2)

Regulation of the apoptotic pathway plays a critical role in inducing tumor cell death and circumventing drug resistance. Survivin protein is the stro......

Tango of dual nanoparticles: Interplays between exosomes and nanomedicine

期刊: BIOENGINEERING & TRANSLATIONAL MEDICINE, 2022; 7 (2)

Exosomes are lipid bilayer vesicles released from cells as a mechanism of intracellular communication. Containing information molecules of their paren......

Graphene quantum dots-based targeted nanoprobes detecting drug delivery, imaging, and enhanced chemotherapy of nasopharyngeal carcinoma

期刊: BIOENGINEERING & TRANSLATIONAL MEDICINE, 2022; 7 (2)

One of the main clinical treatments for advanced nasopharyngeal carcinoma is chemotherapy, but systemic administration can cause serious adverse react......

The efficiency of MSC-based targeted AIE nanoparticles for gastric cancer diagnosis and treatment: An experimental study

期刊: BIOENGINEERING & TRANSLATIONAL MEDICINE, 2022; 7 (2)

Mesenchymal stem cells (MSCs), due to their tumor tropism, are strongly recruited by various solid tumors and mobilized by inflammatory signals in the......

Musical dish efficiently induces osteogenic differentiation of mesenchymal stem cells through music derived microstretch with variable frequency

期刊: BIOENGINEERING & TRANSLATIONAL MEDICINE, 2022; 7 (2)

Nonuniform microstretching (NUMS) naturally occurs in real bone tissues in vivo, but its profound effects have not been identified yet. In order to ex......

Engineering hypertrophic cartilage grafts from lipoaspirate for critical-sized calvarial bone defect reconstruction: An adipose tissue-based developmental engineering approach

期刊: BIOENGINEERING & TRANSLATIONAL MEDICINE, 2022; 7 (3)

Developmental engineering of living implants from different cell sources capable of stimulating bone regeneration by recapitulating endochondral ossif......

Blood vessel remodeling in late stage of vascular network reconstruction is essential for peripheral nerve regeneration

期刊: BIOENGINEERING & TRANSLATIONAL MEDICINE, 2022; 7 (3)

One of the bottlenecks of advanced study on tissue engineering in regenerative medicine is rapid and functional vascularization. For a deeper comprehe......

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